Application | Comment | Organism |
---|---|---|
medicine | PON1 activity and expression levels are important for determining susceptibility to organophosphorus compounds intoxication and risk of developing diseases related to inflammation and oxidative stress | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is synthesized primarily in the liver and secreted into the plasma, where it is associates with high density lipoproteins (HDL) | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
paraoxon + H2O | Homo sapiens | - |
diethyl phosphate + 4-nitrophenol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27169 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
additional information | the enzyme is synthesized primarily in the liver and secreted into the plasma, where it is associates with high density lipoproteins (HDL) | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
paraoxon + H2O | - |
Homo sapiens | diethyl phosphate + 4-nitrophenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
paraoxonase 1 | - |
Homo sapiens |
PON1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | analysis of the role of nuclear receptors in the regulation of PON1 expression | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | paraoxonase 1 (PON1) is a calcium-dependent lactonase synthesized primarily in the liver and secreted into the plasma, where it is associates with high density lipoproteins (HDL). PON1 acts as antioxidant preventing low-density lipoprotein (LDL) oxidation, a process considered critical in the initiation and progression of atherosclerosis. Additionally, PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs). Modulation of PON1 expression by many factors is due to interaction with nuclear receptors (NRs) | Homo sapiens |