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Literature summary for 3.1.8.1 extracted from
- Paraoxonase 1 activities and polymorphisms in autism spectrum disorders (2010), J. Cell. Mol. Med., 14, 600-607.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | both PON1 bioavailability and catalytic activity are decreased in children with autism spectrum disorders | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.611 | - |
using paraoxin as substrate (paraoxonase activity of PON1), at 25°C | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDL-associated esterase/lactonase paraoxonase 1 | - |
Homo sapiens |
| high-density lipoprotein-associated esterase/lactonase | - |
Homo sapiens |
| paraoxonase | - |
Homo sapiens |
| paraoxonase 1 | - |
Homo sapiens |
| PO.ase | - |
Homo sapiens |
| PON1 | catalyses the hydrolysis of arylesters, toxic organophosphate compounds, carbamates and lactones, shows higher arylesterase than paraoxonase activity | Homo sapiens |
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Release 2023.1 (January 2023)
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