Activating Compound | Comment | Organism | Structure |
---|---|---|---|
palmitoyl-lysophosphatidylglycerol | 0.01 mM, 14% stimulation of paraoxonase, 40% stimulation of diazoxonase | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-myristoyl-lysophosphatidylglycerol | selective, noncompetitive inhibition of paraoxonase activity | Homo sapiens | |
1-palmitoyl-lysophosphatidylglycerol | selective, noncompetitive inhibition of paraoxonase activity, charge interactions, inhibition is almost completely suppressed by 1 M NaCl | Homo sapiens | |
1-stearoyl-lysophosphatidylglycerol | selective, noncompetitive inhibition of paraoxonase activity | Homo sapiens | |
lysophosphatidylinositol | inhibition of paraoxonase | Homo sapiens | |
additional information | differential effect of lysophospholipids on activities of native PON1 as well as of high-density lipoprotein or dimyristoylphosphatidylcholine-bound PON1, kinetics, overview | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.42 | - |
paraoxon | pH 7.4, 25°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27169 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diazoxon + H2O | - |
Homo sapiens | ? | - |
? | |
paraoxon + H2O | - |
Homo sapiens | 4-nitrophenol + diethyl phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
paraoxonase 1 | - |
Homo sapiens |
PON1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3400 | - |
paraoxon | pH 8.0, 30°C | Brevundimonas diminuta |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.041 | - |
palmitoyl-lysophosphatidylglycerol | pH 7.4, 25°C | Homo sapiens |