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Information on EC 3.1.8.1 - aryldialkylphosphatase
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3.1.8.1 aryldialkylphosphataseIUBMB Comments
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase.
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Word Map
- 3.1.8.1
- arylesterase
- paraoxonase-1
- cholesterol
- nerve
- atherosclerosis
- cardiovascular
-
low-density
-
insecticide
- triglyceride
- coronary
-
apolipoproteins
- acetylcholinesterase
- malondialdehyde
- diminuta
-
poison
- soman
- p-nitrophenol
-
warfare
- sarin
-
bioremediation
- chlorpyrifos
- vx
-
antiatherogenic
-
decontamination
-
bioscavenger
- atherogenesis
- cholinesterase
- phenylacetate
- medicine
-
binuclear
-
phosphotriesters
-
atherogenic
- flavobacterium
- carboxylesterase
-
hdl-cholesterol
- apoa-i
- butyrylcholinesterase
- fluorophosphate
-
surface-expressed
- diazoxon
- tabun
-
thiolactone
-
g-type
-
salt-stimulated
-
triesters
- malathion
- ochrobactrum
- sphingobium
- radiobacter
- cyclosarin
-
loligo
- synthesis
- environmental protection
- drug development
- degradation
- biotechnology
- diagnostics
- agriculture
- analysis
- nutrition
The enzyme appears in viruses and cellular organisms
Synonyms
pon-1, serum paraoxonase, phosphotriesterase, organophosphorus hydrolase, dfpase, serum paraoxonase 1, pon 1, methyl parathion hydrolase, organophosphate hydrolase, hupon1, 
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topREACTION 
REACTION DIAGRAM
COMMENTARY 
ORGANISM
UNIPROT
LITERATURE
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
mechanism
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an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
mechanism
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an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
catalytic mechanism
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an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
catalytic mechanism
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
kinetics and mechanism
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an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
kinetics and mechanism
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an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
no serine esterase
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an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
acts on organophosphorous compounds, such as paraoxon, including esters of phosphonic acid and phosphinic acids. Inhibited by chelating agents, requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase
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an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
catalytic mechanism and active site structure, substrate docking mechanism
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
catalytic mechanism involving His134 and His115 as well as a Ca2+ ion, active site structure, overview
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
catalytic mechanism, the effects of substrate orientation on the mechanism of the enzyme, energetic parameters, overview
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
mechanism of hydrolysis of organophosphates by the bacterial phosphotriesterase, reaction modelling, kinetic model
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
structure-function analysis, catalytic mechanism involving the residue His285, residues Leu69, His134, Phe222, and Cys284 are involved in substrate binding, Ca2+ is required for activity and is involved in the catalytic mechanism via coordinating residues Asp54, Asn168, Asn224, and Asp269
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
enzyme-substrate complex structure analysis and reaction mechanism, the my-hydroxo bridge between the metal ions initiates the hydrolytic reaction, roles of alpha- and beta-metal ions, contribution of grouns-state destabilization to catalysis, overview, Michaelis complex, transition state, and product structure, overview
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
catalytic reaction with orpanophosphonates starts with cleavageof the P-O bond. Reaction proceeds through a displacement mechanism and generates a chiral product in situ with an inversion of stereochemical configuration at the phosphorous atom
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an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
catalytic reaction mechanism involving residue Asp269, and role of Asp270 for the catalytic function, molecular dynamics and modelling, overview. The reaction is supposed to proceed by a two-step addition-elimination (An + Dn) mechanism, which goes through a common pentavalent intermediate observed in phosphoryl transfer reactions. The first step is the activation of H2O by Asp269 and Glu53 to form a nucleophile hydroxide and a metastable pentavalent complex. Both the residues Asn168 and Asn224 help the leaving group leave through hydrogen bonds
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
hypothetic mechanism of C-P bond cleavage in methylphosphonic acid by recombinant His6-tagged OPH, overview
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
molecular details of the catalytic mechanism of h-PON1
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
reaction mechanism analysis, overview. The phosphoryl oxygen and one of the ester oxygens bind in a bidentate manner to the beta-metal allowing polarization of the phosphorus center. The bridging hydroxide attacks the phosphorus center forming a phosphorane-like transition state with delocalization of charge supported by coordination to the metal as well as the electronegative ester groups. Once the phosphorane species is formed, the pKa of the attacking OH group will be drastically reduced and the proton can be passed to Glu407. In the substrate-docked structure of Sb-PTE, the free oxygen of Glu407 is 4.0 A from the leaving group oxygen, which would enable transfer of the proton to the leaving group, facilitating the collapse of the phosphorane intermediate into products
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol
reaction mechanism of lactonase activity and paraoxonase activity of the enzyme PON1, overview
PATHWAY SOURCE
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