Literature summary for 3.1.8.1 extracted from

Gaidukov, L.; Tawfik, D.S.
High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I (2005), Biochemistry, 44, 11843-11854.

Search for more literature for 3.1.8.1

Activating Compound

Activating Compound	Comment	Organism	Structure
high-density lipoprotein	paraoxonase and arylesterase activities are stimulated by high-density lipoprotein by 2-5fold, almost independently of the apoliporotein content	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.5	-	paraoxon	pH 8.3, activity buffer with 0.01 mM apolipoprotein apoA-I rHDL	Homo sapiens
0.9	-	paraoxon	pH 8.3, activity buffer	Homo sapiens
0.9	-	paraoxon	pH 8.3, activity buffer with 0.1% tergitol	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P27169	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
paraoxon + H2O	-	Homo sapiens	diethylphosphate + 4-nitrophenol	-	?

Synonyms

Synonyms	Comment	Organism
PON1	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
3.3	-	paraoxon	pH 8.3, activity buffer	Homo sapiens
3.7	-	paraoxon	pH 8.3, activity buffer with 0.01 mM apolipoprotein apoA-I rHDL	Homo sapiens
5.8	-	paraoxon	pH 8.3, activity buffer with 0.1% tergitol	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)