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Literature summary for 3.1.8.1 extracted from

  • Khersonsky, O.; Tawfik, D.S.
    Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase (2005), Biochemistry, 44, 6371-6382.
    View publication on PubMed
Search for more literature for 3.1.8.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.8
-
 4-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
0.91
-
 2-fluoro 4-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
1.2
-
 4-diethyl phosphate benzaldehyde pH 8.0 Homo sapiens
1.3
-
 2,6-difluorophenyl diethyl phosphate pH 8.0 Homo sapiens
1.3
-
 3-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
1.56
-
 4-diethyl phosphate acetophenone pH 8.0 Homo sapiens
1.7
-
 3-fluoro 4-nitrophenyl diethyl phosphate
-
 Homo sapiens
1.8
-
 3,5-dinitrophenyl diethyl phosphate pH 8.0 Homo sapiens
1.9
-
 4-diethyl phosphate methyl benzoate pH 8.0 Homo sapiens
1.9
-
 4-cyanophenyl diethyl phosphate pH 8.0 Homo sapiens
1.9
-
 4-chlorophenyl diethyl phosphate pH 8.0 Homo sapiens
2
-
 3-fluorophenyl diethyl phosphate pH 8.0 Homo sapiens
2.1
-
 2,4-dinitrophenyl diethyl phosphate pH 8.0 Homo sapiens
2.1
-
 3-cyanophenyl diethyl phosphate pH 8.0 Homo sapiens
4
-
 pentafluorophenyl diethyl phosphate pH 8.0 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27169
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-dinitrophenyl diethyl phosphate + H2O
-
 Homo sapiens 2,4-dinitrophenol + diethyl phosphate
-
 ?
2,6-difluorophenyl diethyl phosphate + H2O
-
 Homo sapiens 2,6-difluorophenol + diethyl phosphate
-
 ?
2-fluoro-4-nitrophenyl diethyl phosphate + H2O
-
 Homo sapiens 2-fluoro-4-nitrophenol + diethyl phosphate
-
 ?
3,5-dinitrophenyl diethyl phosphate + H2O
-
 Homo sapiens 3,5-dinitrophenol + diethyl phosphate
-
 ?
3-cyanophenyl diethyl phosphate + H2O
-
 Homo sapiens 3-cyanophenol + diethyl phosphate
-
 ?
3-fluoro-4-nitrophenyl diethyl phosphate + H2O
-
 Homo sapiens 3-fluoro-4-nitrophenol + diethyl phosphate
-
 ?
3-fluorophenyl diethyl phosphate + H2O
-
 Homo sapiens 3-fluorophenol + diethyl phosphate
-
 ?
3-nitrophenyl diethyl phosphate + H2O
-
 Homo sapiens 3-nitrophenol + diethyl phosphate
-
 ?
4-acetoxy acetophenone + H2O
-
 Homo sapiens ?
-
 ?
4-chlorophenyl diethyl phosphate + H2O
-
 Homo sapiens 4-chlorophenol + diethyl phosphate
-
 ?
4-cyanophenyl diethyl phosphate + H2O
-
 Homo sapiens 4-cyanophenol + diethyl phosphate
-
 ?
4-diethyl phosphate acetophenone + H2O
-
 Homo sapiens 4-hydroxyacetophenone + diethyl phosphate
-
 ?
4-diethyl phosphate benzaldehyde + H2O
-
 Homo sapiens 4-hydroxybenzaldehyde + diethyl phosphate
-
 ?
4-diethyl phosphate methyl benzoate + H2O
-
 Homo sapiens methyl 4-hydroxybenzoate + diethyl phosphate
-
 ?
4-nitrophenyl diethyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + diethyl phosphate
-
 ?
benzyl acetate + H2O
-
 Homo sapiens ?
-
 ?
diethyl 4-chlorophenyl phosphate + H2O
-
 Homo sapiens 4-chlorophenol + diethyl phosphate
-
 ?
ethyl acetate + H2O
-
 Homo sapiens ?
-
 ?
pentafluorophenyl diethyl phosphate + H2O
-
 Homo sapiens pentafluorophenol + diethyl phosphate
-
 ?
pentafluorophenyl diethyl phosphate + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PON1
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0008
-
 4-chlorophenyl diethyl phosphate pH 8.0 Homo sapiens
0.0011
-
 3-fluorophenyl diethyl phosphate pH 8.0 Homo sapiens
0.02
-
 Benzyl acetate about, pH 8.0, genetic variant PON1 G2E6 Homo sapiens
0.062
-
 2,6-difluorophenyl diethyl phosphate pH 8.0 Homo sapiens
0.076
-
 3-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
0.178
-
 3-cyanophenyl diethyl phosphate pH 8.0 Homo sapiens
0.24
-
 ethyl acetate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
0.27
-
 2,4-dinitrophenyl diethyl phosphate pH 8.0 Homo sapiens
0.4
-
 4-cyanophenyl diethyl phosphate pH 8.0 Homo sapiens
0.44
-
 4-diethyl phosphate acetophenone pH 8.0 Homo sapiens
0.47
-
 4-diethyl phosphate benzaldehyde pH 8.0 Homo sapiens
0.6
-
 pentafluorophenyl diethyl phosphate pH 8.0 Homo sapiens
3.7
-
 2-fluoro 4-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
4.8
-
 4-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
10.2
-
 3,5-dinitrophenyl diethyl phosphate pH 8.0 Homo sapiens
13
-
 4-acetoxy acetophenone pH 8.0, genetic variant PON1 G2E6 Homo sapiens
13.9
-
 3-fluoro 4-nitrophenyl diethyl phosphate pH 8.0 Homo sapiens
656
-
 3-fluorophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
678
-
 pentafluorophenyl diethyl phosphate about, pH 8.0, genetic variant PON1 G2E6 Homo sapiens
840
-
 3-nitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
848
-
 4-chlorophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
950
-
 2,6-difluorophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
1477
-
 3,5-dinitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
1610
-
 3-cyanophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
5485
-
 4-diethyl phosphate methyl benzoate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
7495
-
 4-cyanophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
8080
-
 4-diethyl phosphate acetophenone pH 8.0, genetic variant PON1 G2E6 Homo sapiens
9160
-
 2,4-dinitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
10520
-
 4-nitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
11080
-
 2-fluoro-4-nitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
11680
-
 3-fluoro-4-nitrophenyl diethyl phosphate pH 8.0, genetic variant PON1 G2E6 Homo sapiens
12620
-
 4-diethyl phosphate benzaldehyde pH 8.0, genetic variant PON1 G2E6 Homo sapiens