Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.8.1 extracted from

  • Kotur-Stevuljevic, J.; Spasic, S.; Jelic-Ivanovic, Z.; Spasojevic-Kalimanovska, V.; Stefanovic, A.; Vujovic, A.; Memon, L.; Kalimanovska-Ostric, D.
    PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients (2008), Clin. Biochem., 41, 1067-1073.
    View publication on PubMed

Application

Application Comment Organism
medicine oxidative stress in coronary heart disease patients is maintained by systemic low-grade inflammation, which results in PON1 enzymatic activity exhaustion Homo sapiens

Protein Variants

Protein Variants Comment Organism
Q192R there are substrate-dependent differences among PON1 Q192R isoforms, the Q variant has a higher diazoxonase activity, whereas paraoxonase activity predominates in the R variant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27169
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diazoxon + H2O the homozygote wild type enzyme shows highest activity towards diazoxon Homo sapiens 2-isopropyl-6-methyl-pyrimidin-4-ol + diethyl phosphate
-
?
paraoxon + H2O the homozygote RR phenotype of Q192R shows highest activity towards paraoxon Homo sapiens diethylphosphate + 4-nitrophenol
-
?

Synonyms

Synonyms Comment Organism
paraoxonase 1
-
Homo sapiens
PON1 the enzyme shows paraoxonase and diazoxonase activities Homo sapiens