Application | Comment | Organism |
---|---|---|
medicine | oxidative stress in coronary heart disease patients is maintained by systemic low-grade inflammation, which results in PON1 enzymatic activity exhaustion | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Q192R | there are substrate-dependent differences among PON1 Q192R isoforms, the Q variant has a higher diazoxonase activity, whereas paraoxonase activity predominates in the R variant | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27169 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diazoxon + H2O | the homozygote wild type enzyme shows highest activity towards diazoxon | Homo sapiens | 2-isopropyl-6-methyl-pyrimidin-4-ol + diethyl phosphate | - |
? | |
paraoxon + H2O | the homozygote RR phenotype of Q192R shows highest activity towards paraoxon | Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
paraoxonase 1 | - |
Homo sapiens |
PON1 | the enzyme shows paraoxonase and diazoxonase activities | Homo sapiens |