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Information on EC 1.2.1.9 - glyceraldehyde-3-phosphate dehydrogenase (NADP+)
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EC Tree
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)Specify your search results
Word Map
- 1.2.1.9
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groes
- chaperonins
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refolding
- atpase
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heat-shock
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co-chaperonins
- rhodanese
- groel-groes
- chloroplast
-
heptameric
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tubulins
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double-ring
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encapsulate
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misfolded
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machine
- malate
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anti-hsp60
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equatorial
-
t-complex
- rubisco
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cage
-
toroid
- mg-atp
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co-chaperone
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cryo-electron
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endosymbiotic
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chlamydial
- amp-pnp
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atp-induced
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aphid
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endosymbionts
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molten
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hetero-oligomeric
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coarse-grained
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protein-folding
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back-to-back
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nonnative
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trachomatis
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
triosephosphate dehydrogenase, non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, gap dehydrogenase, apo-gapdh, np-ga3pdhase, apo-glyceraldehyde-3-phosphate dehydrogenase, nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase, np-gapdh, non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase, gapdhn, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
apo-glyceraldehyde-3-phosphate dehydrogenase
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CagapC
CbgapC
CsgapC
dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)
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-
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GAP dehydrogenase
GAPC
GAPDH
GAPDHN
GAPN
glyceraldehyde 3-phosphate dehydrogenase (NADP)
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-
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glyceraldehyde 3-phosphate:NADP+ reductase, non-phosphorylating
glyceraldehyde phosphate dehydrogenase (NADP)
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glyceraldehyde-3-phosphate dehydrogenase
glyceraldehyde-3-phosphate dehydrogenase (NADP+)
Glyceraldehyde-3-phosphate dehydrogenase [NADP+]
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glyceraldehyde-3-phosphate:NADP reductase
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NADP-dependent glyceraldehyde 3-phosphate dehydrogenase
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
NADP-dependent nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase
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NADP-glyceraldehyde phosphate dehydrogenase
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NADP-glyceraldehyde-3-phosphate dehydrogenase
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-
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NADPH-dependent GAPDH
non phosphorylating glyceraldehyde-3-phosphate dehydrogenase
non-phosphorylating GAP dehydrogenase
Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase
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-
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non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase
non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase GAPN
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non-phosphorylating NADP+-dependent glyceraldehyde-3-phosphate dehydrogenase
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non-phosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
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nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase
nonphosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
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NP-Ga3PDHase
NP-GAPDH
SSO3194
St-GAPN
STK_24770
triose phosphate dehydrogenase
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Triosephosphate dehydrogenase
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glyceraldehyde-3-phosphate dehydrogenase (NADP+)
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NADP-dependent glyceraldehyde 3-phosphate dehydrogenase
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non phosphorylating glyceraldehyde-3-phosphate dehydrogenase
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non phosphorylating glyceraldehyde-3-phosphate dehydrogenase
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non phosphorylating glyceraldehyde-3-phosphate dehydrogenase
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non phosphorylating glyceraldehyde-3-phosphate dehydrogenase
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non phosphorylating glyceraldehyde-3-phosphate dehydrogenase
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non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase
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non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase
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non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase
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non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase
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nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase
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-
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-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH + H+
two-step mechanism and kinetics
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D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH + H+
proposed mechanism
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D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH + H+
probably identical with EC 1.2.1.13
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D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH + H+
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
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-
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reduction
oxidation
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-
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reduction
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
9028-92-6
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-phospho-D-glycerate + NADH + H+
D-glyceraldehyde 3-phosphate + NAD+ + H2O
-
-
-
-
r
3-phospho-D-glyceroyl phosphate + NADPH + H+
D-glyceraldehyde 3-phosphate + phosphate + NADP+
D-glyceraldehyde 3-phosphate + H2O + NADP+
(2R)-3-phosphoglycerate + NADPH + 2 H+
-
-
-
?
D-glyceraldehyde 3-phosphate + phosphate + NADP+
3-phospho-D-glyceroyl phosphate + NADPH + H+
-
-
-
-
r
D-glyceraldehyde-3-phosphate + 1,N6-ethenoadenine-nicotinamide dinucleotide phosphate
D-3-phosphoglycerate + ?
-
-
-
-
?
D-glyceraldehyde-3-phosphate + 3-acetylpyridine-adenine dinucleotide phosphate
D-3-phosphoglycerate + ?
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-
-
-
?
D-glyceraldehyde-3-phosphate + beta-nicotinamide adenine dinucleotide 2',3'-cyclic monophosphate
D-3-phosphoglycerate + ?
-
-
-
-
?
D-glyceraldehyde-3-phosphate + nicotinamide-hypoxanthine dinucleotide phosphate
D-3-phosphoglycerate + ?
-
-
-
-
?
DL-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
r
3-phospho-D-glyceroyl phosphate + NADPH + H+
D-glyceraldehyde 3-phosphate + phosphate + NADP+
-
-
-
-
?
3-phospho-D-glyceroyl phosphate + NADPH + H+
D-glyceraldehyde 3-phosphate + phosphate + NADP+
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-
-
-
?
D-glyceraldehyde 3-phosphate + NAD+ + H2O
3-phospho-D-glycerate + NADH + 2 H+
the enzyme prefers NADP+ to NAD+. NAD+ is a poor cosubstrate. The NAD+-dependent reaction of St-GAPN shows no saturation up to 20 mM
-
-
ir
D-glyceraldehyde 3-phosphate + NAD+ + H2O
3-phospho-D-glycerate + NADH + 2 H+
the enzyme prefers NADP+ to NAD+. NAD+ is a poor cosubstrate. The NAD+-dependent reaction of St-GAPN shows no saturation up to 20 mM
-
-
ir
D-glyceraldehyde 3-phosphate + NAD+ + H2O
3-phospho-D-glycerate + NADH + H+
-
-
-
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r
D-glyceraldehyde 3-phosphate + NAD+ + H2O
3-phospho-D-glycerate + NADH + H+
enzyme shows negligible activity with NAD+. The NAD+-dependent reaction shows no saturation at NAD+ concentrations up to 50 mM. The highest enzyme activity is observed at 50 mM NAD+ which is 7fold to 8fold lower than the Vmax observed using NADP+ as cofactor
-
-
ir
D-glyceraldehyde 3-phosphate + NAD+ + H2O
3-phospho-D-glycerate + NADH + H+
NAD+ is a poor co-substrate
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
-
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
-
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
-
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
-
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase is a key-enzyme of the semi-phosphorylative branch of the EntnerDoudoroff pathway
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-
ir
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
-
-
-
r
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
-
-
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ir
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
the enzyme prefers NADP+ to NAD+. NAD+ is a poor cosubstrate. The NAD+-dependent reaction of St-GAPN shows no saturation up to 20 mM. K-type allosterism in which the positive cooperativity is abolished with concomitant activation by D-glucose 1-phosphate
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-
ir
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
-
-
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ir
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + 2 H+
the enzyme prefers NADP+ to NAD+. NAD+ is a poor cosubstrate. The NAD+-dependent reaction of St-GAPN shows no saturation up to 20 mM. K-type allosterism in which the positive cooperativity is abolished with concomitant activation by D-glucose 1-phosphate
-
-
ir
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
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-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
ir
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?, ir
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
?
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
ir
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
-
ir
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
-
ir
D-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-D-glycerate + NADPH + H+
-
-
-
-
ir
D-glyceraldehyde-3-phosphate + NAD+
D-3-phosphoglycerate + NADH + H+
weak reaction
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-
ir
D-glyceraldehyde-3-phosphate + NAD+
D-3-phosphoglycerate + NADH + H+
weak reaction
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-
ir
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
-
ir
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
?
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
-
?
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
-
ir
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
-
ir
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
-
ir
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
absolutely specific for D-isomer
-
ir
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
may be part of a system that is responsible for the export of photosynthetically generated NADPH from chloroplast to cytoplasm
-
-
ir
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
-
?
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
ir
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
-
ir
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
two-step mechanism
-
-
ir
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
rate-limiting step in wild-type enzyme and in mutant enzymes R124L, and Y170F is deacylation. Rate limiting step in mutant enzymes R301L and R459I is acylation
-
-
?
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
-
?
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
r
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
r
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
-
?
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
-
?
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH
-
-
-
?
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH + H+
-
-
-
ir
D-glyceraldehyde-3-phosphate + NADP+
D-3-phosphoglycerate + NADPH + H+
-
-
-
ir
DL-glyceraldehyde 3-phosphate + NAD+ + H2O
3-phospho-DL-glycerate + NADH + H+
NADP+ is much more efficient than NAD+
-
-
ir
DL-glyceraldehyde 3-phosphate + NAD+ + H2O
3-phospho-DL-glycerate + NADH + H+
NADP+ is much more efficient than NAD+
-
-
ir
DL-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-DL-glycerate + NADPH + H+
-
-
-
ir
DL-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-DL-glycerate + NADPH + H+
-
-
-
ir
DL-glyceraldehyde 3-phosphate + NADP+ + H2O
3-phospho-DL-glycerate + NADPH + H+
-
-
-
-
?
additional information
?
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recombinant CbgapC shows no catalytic activity
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-
-
additional information
?
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Clostridium beijerinckii DSM 1739
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recombinant CbgapC shows no catalytic activity
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-
additional information
?
-
ALDH superfamily represents a group of enzymes that catalyze the oxidation of endogenous and exogenous aldehydes to the corresponding carboxylic acids
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-
?
additional information
?
-
-
the enzyme shows only negligible activity with NAD+
-
-
?
additional information
?
-
the enzyme shows only negligible activity with NAD+
-
-
?
additional information
?
-
the enzyme shows only negligible activity with NAD+
-
-
?
additional information
?
-
the enzyme shows only negligible activity with NAD+
-
-
?