EC Number   |
General Information |
Reference |
|---|
    1.2.1.9 | malfunction |
DELTAgapN cells do not grow under glycolytic conditions |
726000 |
| 1.2.1.9 | malfunction |
single amino acid substitution, known to abolish the NADP+ binding, cancelled the calorimetric effect of the coenzyme NADP+ |
741834 |
| 1.2.1.9 | metabolism |
replacement of Escherichia coli GapA glyceraldehyde 3-phosphate dehydrogenase, EC 1.2.1.12 by Clostridium acetobutylicum GapC glyceraldehyde 3-phosphate dehydrogenase, EC 1.2.1.9 results in significant reduction of flux through the pentose phosphate pathway. Recombinant strains display increased NADPH availability, and consistently higher productivity than parent strains |
699988 |
| 1.2.1.9 | metabolism |
the EMP pathway can be controlled through the glyceraldehyde 3-phosphate node by NAD+-GAPDH activity, recombinant NADP+-GAPDH heterologous activity can also exert a similar response, which modulates the glucose uptake and also the acetic acid production rate |
741625 |
| 1.2.1.9 | metabolism |
the enzyme plays a key role in providing NADPH under glycolytic conditions |
726000 |
| 1.2.1.9 | physiological function |
the enzyme is known to be crucial for the effective supply of the reducing equivalents in Streptococcus mutans and its ability to grow under aerobic conditions |
741834 |
| 1.2.1.9 | physiological function |
when endogenous phosphorylating NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Corynebacterium glutamicum is replaced by nonphosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (GapN) from Clostridium acetobutylicum, this NADPH-generating glycolytic pathway does not allow for the growth of Corynebacterium glutamicum with glucose as the sole carbon source. Heterologous expression of udhA encoding soluble transhydrogenase from Escherichia coli partly restores growth |
739907 |
