Information on EC 3.5.2.6 - beta-lactamase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
3.5.2.6
-
RECOMMENDED NAME
GeneOntology No.
beta-lactamase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
-
-
-
-
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
Arg234 is involved in catalysis
P16897
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
2-step mechanism: in the first step, the catalytic Ser64 attacks the carbonyl carbon of the beta-lactam ring, forming an acyl intermediate, in the second step, a deacylating water hydrolyzes the ester bond to regenerate the enzyme and the reaction product, hydrolyzed antibiotic
P00811
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
Glu166 is important for catalysis, mechanism
P00808
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
reaction and kinetic mechanism
-
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
enzyme-ligand interaction-structure, computational analysis, residues K67, N152, Y150, and K315 are involved in substrate binding, tetrahedral intermediate
-
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
active site, Asp120 is important for catalysis, as well as substrate and Zn2+ binding
P52700
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
catalytic mechanism of enzyme class D, unique in comparison with classes A and C, active site structure with elements S-X-X-K, S-X-N, and K-T/S-G
P14489
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
reaction mechanism, Lys70 is involved in catalysis, active site structure
-
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
VIM-2 catalytic Cys221, located in the Cys site, shows a high tendency to be strongly oxidized becoming a cysteinesulfonic residue, active site structure, overview
-
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
reaction and kinetic mechanism
Enterobacter cloacae GC1
-
-
a beta-lactam + H2O = a substituted beta-amino acid
show the reaction diagram
enzyme-ligand interaction-structure, computational analysis, residues K67, N152, Y150, and K315 are involved in substrate binding, tetrahedral intermediate; reaction and kinetic mechanism
Enterobacter cloacae P99
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
carboxylic acid amide hydrolysis
-
-
-
-
hydrolysis
-
-
PATHWAY
KEGG Link
MetaCyc Link
beta-Lactam resistance
-
Biosynthesis of secondary metabolites
-
Penicillin and cephalosporin biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
beta-lactam hydrolase
A group of enzymes of varying specificity hydrolysing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. The latter were formerly listed as EC 3.5.2.8, cephalosporinase.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
ACT-3
A1EGT8
plasmid-encoded class C beta-lactamase
Ambler class A beta-lactamase
-
-
ambler class C beta-lactamase
Q20I87
-
ambler class C beta-lactamase
Yersinia ruckeri 1006/94
Q20I87
-
-
AmpC
Acinetobacter baylyi ADP1
Q0VJU2
-
-
AmpC
Q6T3Q5
-
AmpC
Citrobacter freundii 4306
-
-
-
AmpC
P00811
-
AmpC
Morganella morganii No. 14337
-
-
-
AmpC
Q3HLW6
-
AmpC
Yersinia frederiksenii C-115
Q1W755
-
-
AmpC
Q1W758
-
AmpC
Yersinia intermedia C-702
Q1W758
-
-
AmpC
Q20I87
-
AmpC
Yersinia ruckeri 1006/94
Q20I87
-
-
AmpC beta-lactamase
Q7WZ37
-
AmpC beta-lactamase
P00811
-
AmpC beta-lactamase
Q76DI4
-
AmpC beta-lactamase
Escherichia coli HKY28
Q76DI4
-
-
AmpC beta-lactamase
Q6GVZ4
-
AmpC beta-lactamase
Q704Y9, Q704Z0, Q705J0
-
AmpC beta-lactamase
Morganella morganii PP19
Q705J0
-
-
AmpC beta-lactamase
Morganella morganii PP29
Q704Z0
-
-
AmpC beta-lactamase
Morganella morganii PP37
Q704Y9
-
-
AmpC beta-lactamases M19
Q705J0
-
AmpC beta-lactamases M19
Morganella morganii PP19
Q705J0
-
-
AmpC beta-lactamases M29
Q704Z0
-
AmpC beta-lactamases M29
Morganella morganii PP29
Q704Z0
-
-
AmpC beta-lactamases M37
Q704Y9
-
AmpC beta-lactamases M37
Morganella morganii PP37
Q704Y9
-
-
AmpC M19
Q705J0
-
AmpC M19
Morganella morganii PP19
Q705J0
-
-
AmpC M29
Q704Z0
-
AmpC M29
Morganella morganii PP29
Q704Z0
-
-
AmpC M37
Q704Y9
-
AmpC M37
Morganella morganii PP37
Q704Y9
-
-
AmpC-A
P00811
-
AmpC-B2
P00811
-
AmpC-type beta-lactamase
A1EGT8
-
apo Bacillus cereus 569/H/9 enzyme
-
metal-free BcII
apo-BcII
-
-
B1 metallo-beta-lactamase
-
-
BCL-1
A8RR46
-
BCL-1
Bacillus clausii NR
A8RR46
-
-
Beta lactamase OXA-10
-
-
-
-
beta-lactamase
-
-
-
-
beta-lactamase
-
-
beta-lactamase
-
-
beta-lactamase
B8R6A5, C1J897, C1J899, C1J8A0
-
beta-lactamase
-
-
beta-lactamase
Citrobacter freundii 4306
-
-
-
beta-lactamase
Q1KY81
-
beta-lactamase
Enterobacter aerogenes SS-13
Q1KY81
-
-
beta-lactamase
Q59401
-
beta-lactamase
Enterobacter cloacae P99
Q59401
-
-
beta-lactamase
-
-
beta-lactamase
A3RIY0
AmpC-type plasmid-mediated
beta-lactamase
P00811
-
beta-lactamase
P13661
-
beta-lactamase
P62593
-
beta-lactamase
Escherichia coli E384
A3RIY0
AmpC-type plasmid-mediated
-
beta-lactamase
Q4TVR4
-
beta-lactamase
Q7AYX1
-
beta-lactamase
A5LH21
-
beta-lactamase
Shigella sonnei UIH-1
A5LH21
-
-
beta-lactamase
-
-
beta-lactamase
Yersinia enterocolitica IP97
-
-
-
beta-lactamase A-C
-
different in substrate specifity, amino acid sequence, mechanistic properties, metal ion requirement
beta-lactamase ACT-1
-
-
beta-lactamase AME I
-
-
-
-
beta-lactamase Bla-A
Q58G58
-
beta-lactamase Bla-B
Q45EY0
-
beta-lactamase CMY-1
-
-
beta-lactamase CMY-2
-
-
beta-lactamase I-III
-
-
beta-lactamase I-III
-
different in molecular weight, localization, metal ion requirement
beta-lactamase I-III
Bacillus cereus 5/B
-
-
-
beta-lactamase I-III
Bacillus cereus 569/H/9
-
; different in molecular weight, localization, metal ion requirement; different in molecular weight, localization, metal ion requirement; different in molecular weight, localization, metal ion requirement
-
beta-lactamase I-III
-
different in molecular weight, localization, metal ion requirement
beta-lactamase II
-
-
-
-
beta-lactamase MIR-1
-
-
beta-lactamase OXA-1
-
-
beta-lactamase OXA-10
-
-
beta-lactamase OXA-10
plasmid pGEM-T-easy
-
-
beta-lactamase P99
-
-
beta-lactamase P99
Enterobacter cloacae P99
-
-
-
beta-lactamase PSE-1
Q7BHJ5
-
beta-lactamase YRC-1
Q20I87
-
beta-lactamase, class C
Q704Y9, Q704Z0
-
beta-lactamase, class C
Morganella morganii PP29
Q704Z0
-
-
beta-lactamase, class C
Morganella morganii PP37
Q704Y9
-
-
beta-lactamases CTX-M-25
Q8KSA6
-
beta-lactamases CTX-M-26
Q8GD10
-
beta-lactamse A-D
-
A,C and D enzymes utilize a nucleophilic serine at the active center which becomes acylated by substrate, B enzymes are metalloenzymes requiring Zn2+ for activity
beta-lactamse A-D
Bacillus cereus 569/H/9
-
A,C and D enzymes utilize a nucleophilic serine at the active center which becomes acylated by substrate, B enzymes are metalloenzymes requiring Zn2+ for activity
-
beta-lactamse A-D
-
-
beta-lactamse A-D
Escherichia coli DH5alpha
-
-
-
beta-lactamse A-D
-
A,C and D enzymes utilize a nucleophilic serine at the active center which becomes acylated by substrate, B enzymes are metalloenzymes requiring Zn2+ for activity
beta-lactamse A-D
Staphylococcus aureus PC1
-
A,C and D enzymes utilize a nucleophilic serine at the active center which becomes acylated by substrate, B enzymes are metalloenzymes requiring Zn2+ for activity
-
Bla-A
Q1W755
constitutive class A penicillinase
Bla-A
Yersinia frederiksenii C-115
Q1W755
constitutive class A penicillinase
-
Bla-A
Q1W758
constitutive class A penicillinase
Bla-A
Yersinia intermedia C-702
Q1W758
constitutive class A penicillinase
-
Bla-B
Q1W755
inducible class C cephalosporinase
Bla-B
Yersinia frederiksenii C-115
Q1W755
inducible class C cephalosporinase
-
Bla-B
Q1W758
inducible class C cephalosporinase
Bla-B
Yersinia intermedia C-702
Q1W758
inducible class C cephalosporinase
-
BlaA
Yersinia enterocolitica IP97
-
-
-
BlaA
Yersinia enterocolitica Y56
Q01166
-
-
BlaC
-
is an an extended spectrum beta-lactamase
BLAIMP
-
-
-
-
blaLUT-1
Q670S6
gene name
blaoxa-1
-
gene name
blaSHV-1
-
gene name
blaVIM-2
Q7BJM5
-
CAR-1 enzyme
Q6D395
-
carbapenem-hydrolysing MBL
Q9K2N0
-
carbapenem-hydrolyzing ambler class D beta-lactamase
Q6VCW0
-
carbapenem-hydrolyzing class A beta-lactamase
Q6JP75
-
carbapenem-hydrolyzing class A beta-lactamase
Serratia fonticola UTAD54.
Q6JP75
-
-
carbapenemase
-
-
-
-
carbapenemase
P26918
-
carbapenemase
Q2HY42, Q9XAY4
-
carbapenemase
Pseudomonas aeruginosa SL2
Q2HY42, Q9XAY4
-
-
carbapenemase
Q8GCU7
-
carbapenemase
Q53BU0, Q53BU1
-
carbapenemase CphA
-
-
Carbenicillinase
-
-
-
-
Carbenicillinase
-
-
cefotaximase
-
-
-
-
ceftazidimase
-
-
-
-
cefurooximase
-
-
-
-
Cefuroximase
-
-
-
-
Cephalosporinase
-
-
-
-
Cephalosporinase
B2BSN6
-
Cephalosporinase
P00811
-
Cephalosporinase
-
-
Cephalosporinase
Q840P9
-
Cephalosporinase
Q20I87
-
Cephalosporinase
Yersinia ruckeri 1006/94
Q20I87
-
-
CIA-1
Chryseobacterium indologenes ATCC 29897
G9M9P7
-
-
CKO
Citrobacter koseri CK4
-
-
-
class A beta-lactamase
-
-
class A beta-lactamase
Q8KQ59
-
class A beta-lactamase
-
-
class A beta-lactamase
-
-
class A beta-lactamase CKO-1
Q8RNV0
-
class A beta-lactamase CKO-2
Q708V4
-
class A beta-lactamase CKO-3
Q708V3
-
class A beta-lactamase CKO-4
Q9AL74
-
class A TEM-2 beta-lactamase
-
-
class A TEM-2 enzyme
P62593
-
class B beta-lactamase SFB-1
Q53BU0
-
class B beta-lactamase SLB-1
Q53BU1
-
class B carbapenemase
-
-
class B metallo-beta-lactamase
-
-
class B metallo-beta-lactamase L-1
-
-
class C beta-lactamase
-
-
class C beta-lactamase
Q59401
-
class C beta-lactamase
Enterobacter cloacae P99
-
;
-
class C beta-lactamase
Enterobacter cloacae P99
Q59401
-
-
class C beta-lactamase
A1EGT8
-
class C P99 beta-lactamase
-
-
class C P99 beta-lactamase
Enterobacter cloacae P99
-
-
-
class D beta lactamase
E7BCS7
-
class D beta-lactamase
Q6XL56
-
class D OXA-1 beta-lactamase
P13661
-
class D oxacillinase
-
-
CMY-37
Citrobacter freundii 4306
-
-
-
CTX-M beta-lactamase
P28585
-
CTX-M-1
P28585
-
CTX-M-14
-
-
CTX-M-14
Escherichia coli TUM1121
-
-
-
CTX-M-64
A5LH21
a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases
CTX-M-64
Shigella sonnei UIH-1
A5LH21
a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases
-
CTX-M-64 beta-lactamase
A5LH21
-
CTX-M-64 beta-lactamase
Shigella sonnei UIH-1
A5LH21
-
-
ESBL
Q3HLW6
-
Est-Y29
-
oligomeric beta-lactamase
exo-small beta-lactamase
-
-
extended spectrum beta-lactamase
G9M9P7
-
extended spectrum beta-lactamase
Chryseobacterium indologenes ATCC 29897
G9M9P7
-
-
extended spectrum beta-lactamase
-
-
extended-spectrum beta-lactamase
-
-
extended-spectrum beta-lactamase
Enterobacter aerogenes 255B4
-
-
-
extended-spectrum beta-lactamase
-
-
extended-spectrum beta-lactamase
-
-
extended-spectrum beta-lactamase
-
-
extended-spectrum beta-lactamase
-
-
extended-spectrum beta-lactamase
Q8KQ59
-
extended-spectrum beta-lactamase
-
-
extended-spectrum beta-lactamase
-
-
extended-spectrum beta-lactamase
-
-
extended-spectrum beta-lactamase TEM-60
-
-
extended-spectrum-beta-lactamase
-
-
FEZ-1 metallo-beta-lactamase
-
-
GC1 beta-lactamase
-
-
GC1 beta-lactamase
Enterobacter cloacae GC1, Enterobacter cloacae P99
-
-
-
GES-5
Q09HD0
an extended-spectrum class A beta-lactamase
GES-5
Klebsiella pneumoniae CHAK36
Q09HD0
an extended-spectrum class A beta-lactamase
-
Imipenem-cefoxitin hydrolyzing enzyme
-
-
-
-
imipenemase
-
-
-
-
IMP-1
Pseudomonas aeruginosa blaIMP-cluster-producingstrains
Q79MP6
-
-
IMP-1
P52699
-
IMP-10
Q7DH52
-
IMP-12
Q8GIW8
-
IMP-13
Q7WYA8
-
IMP-15
Q53CM3
-
IMP-18
Q5U807
-
IMP-18
Pseudomonas aeruginosa PS297
Q5U807
-
-
IMP-9-type metallo-beta-lactamase
Q93M23
-
IMP-like metallo-beta-lactamase
Q8GIW8
-
IMP-type beta-lactamase
-
-
IMP-type metallo-beta-lactamase
-
-
KHM-1
A8R403
-
KLUA-9
Kluyvera ascorbata 68
-
-
-
KPC-2 beta-lactamase
plasmid pBC
-
-
L1 beta-lactamase
B1NLE9
-
L1 beta-lactamase
Stenotrophomonas maltophilia KJ
B1NLE9
-
-
L1 metallo-beta-lactamase
-
-
L2 beta-lactamase
B5KLI1
-
L2 beta-lactamase
Q9RBQ1
-
L2 beta-lactamase
Stenotrophomonas maltophilia KJ
Q9RBQ1
-
-
LUT-1 beta-lactamase
Q670S6
-
M19
Morganella morganii PP19
Q705J0
-
-
M29
Morganella morganii PP29
Q704Z0
-
-
M37
Morganella morganii PP37
Q704Y9
-
-
MbetaL
Q53CM3
-
MbetaL
Pseudomonas aeruginosa M5109
-
-
-
mbetal L1
-
-
MBL
Klebsiella pneumoniae 2873
-
-
-
MBL
Pseudomonas aeruginosa SL2
Q2HY42
-
-
metallo-beta -lactamase
-
-
metallo-beta-L-lactamase
Q9K2N0
-
metallo-beta-lactamase
-
-
-
-
metallo-beta-lactamase
-
-
metallo-beta-lactamase
-
-
metallo-beta-lactamase
P26918
-
metallo-beta-lactamase
O31272
-
metallo-beta-lactamase
-
-
metallo-beta-lactamase
Q6JE29
-
metallo-beta-lactamase
A8R403
-
metallo-beta-lactamase
-
-
metallo-beta-lactamase
Q4ZE97
-
metallo-beta-lactamase
-
-
metallo-beta-lactamase
Klebsiella pneumoniae 2873
-
-
-
metallo-beta-lactamase
Q6D395
-
metallo-beta-lactamase
Q2HY42
-
metallo-beta-lactamase
Q53CM3
-
metallo-beta-lactamase
Q79MP6
-
metallo-beta-lactamase
Q7BHJ5
-
metallo-beta-lactamase
Q7DH52
-
metallo-beta-lactamase
Q840P9
-
metallo-beta-lactamase
Q9K2N0
-
metallo-beta-lactamase
Q9XAY4
-
metallo-beta-lactamase
Pseudomonas aeruginosa blaIMP-cluster-producingstrains
Q79MP6
-
-
metallo-beta-lactamase
Pseudomonas aeruginosa M5109
-
-
-
metallo-beta-lactamase
Pseudomonas aeruginosa SL2
Q2HY42, Q9XAY4
-
-
metallo-beta-lactamase
-
-
metallo-beta-lactamase
Q7BJM5
-
metallo-beta-lactamase
Q8GCU7
-
metallo-beta-lactamase
-
-
metallo-beta-lactamase BceII
-
-
metallo-beta-lactamase BcII
-
-
metallo-beta-lactamase ImiS
-
-
metallo-beta-lactamase IMP-1
-
-
metallo-beta-lactamase L1
-
-
metallo-beta-lactamase L1
P52700
-
metallo-beta-lactamase VIM-1
Q8G979
-
metallo-beta-lactamase VIM-2
-
-
metallo-beta-lactamase VIM-6
Q8GCU7
-
MIR-4 beta-lactamase
A3RIY0
-
neutrapen
-
-
-
-
OXA group I
-
-
OXA group II
-
-
OXA-1
P13661
-
oxa-1 beta-lactamase
-
-
oxa-1 beta-lactamase
-
-
oxa-1 beta-lactamase
-
class D enzyme
oxa-1 beta-lactamase
P13661
-
oxa-1 beta-lactamase
-
-
OXA-10
Q6QJ55
-
OXA-10 beta-lactamase
-
-
OXA-10 enzyme
-
-
OXA-17
Q27JM4
-
OXA-229
I6S7G0
-
OXA-48 carbapenemase
Q6XEC0
-
Oxa-50
Q6PL88
-
OXA-55
Q6VCW0
-
OXA-63
Q50H31
-
OXA-63
Brachyspira pilosicoli BM4442
Q50H31
-
-
OXA-type metallo-beta-lactamase
-
-
OXA114
B3FIE3
a class D beta-lactamase
OXA114
Achromobacter xylosoxidans CIP69598
B3FIE3
a class D beta-lactamase
-
Oxacillinase
-
-
-
-
Oxacillinase
B3FIE3
-
Oxacillinase
Achromobacter xylosoxidans CIP69598
B3FIE3
-
-
Oxacillinase
-
-
Oxacillinase
-
-
oxycillinase
Q5I2N2
-
P99 beta-lactamase
-
-
P99 beta-lactamase
-
class C enzyme
P99 beta-lactamase
P05364
-
P99 beta-lactamase
Enterobacter cloacae 293HT6, Enterobacter cloacae GC1
-
-
-
P99 beta-lactamase
Enterobacter cloacae P99
-
;
-
PenB1 beta-lactamase
B8R6A5
-
penicillinase
-
-
-
-
penicillinase
-
-
penicillinase I, II
-
different in substrate specificity, pH and temperature stability, molecular weight
penicillinase I, II
Bacillus sp. No. 170
-
different in substrate specificity, pH and temperature stability, molecular weight
-
plasmidic class C beta-lactamase
-
-
serine beta-lactamase
-
-
serine beta-lactamase
Enterobacter cloacae P99
-
;
-
serine beta-lactamase
-
-
SFC-1
Q6JP75
-
SFC-1
Serratia fonticola UTAD54.
Q6JP75
-
-
Sfh-I
Q9RMI1
-
Sfh-I
Q9RMI1
-
-
SHV beta-lactamase
-
-
SHV-1
Klebsiella pneumoniae 15571
P0AD64
-
-
SHV-1 beta-lactamase
-
-
SHV-1 penicillinase
-
-
SHV-2A
-
-
-
-
SHV-5
P0A3M1
-
SHV-55
Q4TVR4
-
SHV-type beta-lactamase
-
-
SHV-type extended spectrum beta-lactamase
-
-
ST1585
Q970L2
-
TEM extended-spectrum beta-lactamase
Q3HLW6
-
TEM-1
P62593
-
TEM-1
plasmid pQE32Chl17
-
-
TEM-1 beta-lactamase
-
-
TEM-1 beta-lactamase
P62593
-
TEM-1 beta-lactamase
Escherichia coli RB791
-
-
-
TEM-1 beta-lactamase
plasmid pBG66
-
class A beta-lactamase
TEM-107
Q8KQ59
-
TEM-116
Q3HLW6
-
TEM-149
Q1KY81
-
TEM-149
Enterobacter aerogenes SS-13
Q1KY81
-
-
TEM-type beta-lactamase
-
-
THIN-B metallo-beta-lactamase
-
-
Toho-1
Q47066
-
Verona integron-encoded MBL
Q9K2N0
-
Verona integron-encoded MBL-2
Q9K2N0
-
VIM-1
Morganella morganii A209
-
-
-
VIM-1
Pseudomonas aeruginosa SL2
Q9XAY4
-
-
VIM-1 metallo-beta-lactamase
Q8G979
-
VIM-11
Pseudomonas aeruginosa M5109
-
-
-
VIM-12
-
a hybrid VIM-1/VIM-2 metallo-beta-lactamase
VIM-12
Klebsiella pneumoniae 2873
-
a hybrid VIM-1/VIM-2 metallo-beta-lactamase
-
VIM-13
-, Q2HY42
-
VIM-13
Pseudomonas aeruginosa SL2
Q2HY42
-
-
VIM-2 metallo-beta-lactamase
-
-
VIM-5
Q4ZE97
-
VIM-6
Q8GCU7
-
VIM-6 enzyme
Q8GCU7
-
VIM-metallo beta-lactamase
-
-
VIM-type MBL
-
-
VIM-type MBL
Morganella morganii A209
-
-
-
VIM-type MBL
-, Q9F629
-
VIM-type metallo-beta-lactamase
-, Q9F629
-
YRC-1
Q20I87
-
YRC-1
Yersinia ruckeri 1006/94
Q20I87
-
-
zinc beta-lactamase
-
-
zinc beta-lactamase
-
-
Zn-beta-lactamase
Q9K2N0
-
MIR-4 beta-lactamase
Escherichia coli E384
A3RIY0
-
-
additional information
-
no metallo-beta-lactamase, MBL, in Pseudomonas aeruginosa
additional information
Q9K2N0
VIM-2 belongs to the B1 subfamily ofMBLs
CAS REGISTRY NUMBER
COMMENTARY
9073-60-3
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
strain CIP69598, previously Alcaligenes xylosoxidans
UniProt
Manually annotated by BRENDA team
Achromobacter xylosoxidans CIP69598
strain CIP69598, previously Alcaligenes xylosoxidans
UniProt
Manually annotated by BRENDA team
clinical isolate
SwissProt
Manually annotated by BRENDA team
from genetically distinct carbapenem-resistant strains from Argentina
SwissProt
Manually annotated by BRENDA team
strain ADP1
UniProt
Manually annotated by BRENDA team
Acinetobacter baylyi ADP1
strain ADP1
UniProt
Manually annotated by BRENDA team
clinical strain of genomic species 3
SwissProt
Manually annotated by BRENDA team
IMP-1 producing strains A3035, A4861, A3880, A68, A4764, A4468, A129046, A695 and A696, and SIM-1 producing strain YMC 03/9/T104
-
-
Manually annotated by BRENDA team
produces only one beta-lactamase belonging to molecular class C
UniProt
Manually annotated by BRENDA team
strain 163a
-
-
Manually annotated by BRENDA team
strain AER14M
-
-
Manually annotated by BRENDA team
Aeromonas sobria 163a
strain 163a
-
-
Manually annotated by BRENDA team
Aeromonas sobria AER14M
strain AER14M
-
-
Manually annotated by BRENDA team
bv. sobria
-
-
Manually annotated by BRENDA team
class A enzyme Bla1
-
-
Manually annotated by BRENDA team
569/H/9
Uniprot
Manually annotated by BRENDA team
strain 569/H/9; strain 5/B
-
-
Manually annotated by BRENDA team
Bacillus cereus 5/B
strain 5/B
-
-
Manually annotated by BRENDA team
Bacillus cereus 569/H/9
569/H/9
Uniprot
Manually annotated by BRENDA team
Bacillus cereus 569/H/9
strain 569/H/9
-
-
Manually annotated by BRENDA team
strain NR
UniProt
Manually annotated by BRENDA team
Bacillus clausii NR
strain NR
UniProt
Manually annotated by BRENDA team
class A enzyme BS3
Uniprot
Manually annotated by BRENDA team
strain 6346/C; strain 749/C
-
-
Manually annotated by BRENDA team
strain 749/C
-
-
Manually annotated by BRENDA team
Bacillus licheniformis 6346/C
strain 6346/C
-
-
Manually annotated by BRENDA team
Bacillus licheniformis 749/C
strain 749/C
-
-
Manually annotated by BRENDA team
Bacillus licheniformis BS3
strain BS3
-
-
Manually annotated by BRENDA team
strain No. 170
-
-
Manually annotated by BRENDA team
Bacillus sp. No. 170
strain No. 170
-
-
Manually annotated by BRENDA team
pathogenic bacteria
-
-
Manually annotated by BRENDA team
strain B371
-
-
Manually annotated by BRENDA team
Bacteroides uniformis B371
strain B371
-
-
Manually annotated by BRENDA team
strain BM4442
UniProt
Manually annotated by BRENDA team
Brachyspira pilosicoli BM4442
strain BM4442
UniProt
Manually annotated by BRENDA team
Chryseobacterium indologenes ATCC 29897
-
UniProt
Manually annotated by BRENDA team
strain 4306
-
-
Manually annotated by BRENDA team
strain GN7391
-
-
Manually annotated by BRENDA team
Citrobacter freundii 4306
strain 4306
-
-
Manually annotated by BRENDA team
Citrobacter freundii GN7391
strain GN7391
-
-
Manually annotated by BRENDA team
strain CK4, previously known as Levinea malonatica
-
-
Manually annotated by BRENDA team
strain VAN
-
-
Manually annotated by BRENDA team
Citrobacter koseri CK4
strain CK4, previously known as Levinea malonatica
-
-
Manually annotated by BRENDA team
Citrobacter koseri VAN
strain VAN
-
-
Manually annotated by BRENDA team
strain CB269
-
-
Manually annotated by BRENDA team
strain NBL3
-
-
Manually annotated by BRENDA team
Clostridium butyricum CB269
strain CB269
-
-
Manually annotated by BRENDA team
Clostridium butyricum NBL3
strain NBL3
-
-
Manually annotated by BRENDA team
basonym Alcaligenes eutrophus
-
-
Manually annotated by BRENDA team
class B enzyme BlaB, subclass B1
-
-
Manually annotated by BRENDA team
strain 1082E
-
-
Manually annotated by BRENDA team
strain 255B4
-
-
Manually annotated by BRENDA team
Enterobacter aerogenes 1082E
strain 1082E
-
-
Manually annotated by BRENDA team
Enterobacter aerogenes 255B4
strain 255B4
-
-
Manually annotated by BRENDA team
Enterobacter aerogenes SS-13
SS-13
UniProt
Manually annotated by BRENDA team
class C enzyme P99
-
-
Manually annotated by BRENDA team
stain NOR-1
-
-
Manually annotated by BRENDA team
strain 293HT6
-
-
Manually annotated by BRENDA team
strain 908R
Uniprot
Manually annotated by BRENDA team
strain GC1; strain P99; strains P99 and GCI, class C enzymes
-
-
Manually annotated by BRENDA team
strain P99, class C beta-lactamase
-
-
Manually annotated by BRENDA team
strain P99, class C enzyme
Uniprot
Manually annotated by BRENDA team
VIM-1 producing strains 75-10344, ECL3 and ECL4, and IMP-1 producing strain 199
-
-
Manually annotated by BRENDA team
Enterobacter cloacae 293HT6
strain 293HT6
-
-
Manually annotated by BRENDA team
Enterobacter cloacae 908R
strain 908R
Uniprot
Manually annotated by BRENDA team
Enterobacter cloacae GC1
strain GC1
-
-
Manually annotated by BRENDA team
Enterobacter cloacae NOR-1
stain NOR-1
-
-
Manually annotated by BRENDA team
Enterobacter cloacae P99
P99
-
-
Manually annotated by BRENDA team
Enterobacter cloacae P99
P99
Uniprot
Manually annotated by BRENDA team
Enterobacter cloacae P99
P99
UniProt
Manually annotated by BRENDA team
Enterobacter cloacae P99
strain P99
-
-
Manually annotated by BRENDA team
Enterobacter cloacae P99
strain P99, class C beta-lactamase
-
-
Manually annotated by BRENDA team
Enterobacter cloacae P99
strain P99, class C enzyme
Uniprot
Manually annotated by BRENDA team
strain 254G9, strain 4952, strain 192c3, strain 2662, strain 3701, strain 3806 and strain 02C9
-
-
Manually annotated by BRENDA team
class A enzyme TEM-1
UniProt
Manually annotated by BRENDA team
class A enzyme TEM-1
-
-
Manually annotated by BRENDA team
class A TEM-2 enzyme Escherichia coli
UniProt
Manually annotated by BRENDA team
class D enzyme OXA-1
-
-
Manually annotated by BRENDA team
class D OXA-1 beta-lactamase, E. coli
UniProt
Manually annotated by BRENDA team
containing the TEM-1 beta-lactamase expression plasmid DNA
UniProt
Manually annotated by BRENDA team
isolates from Colombian hospitals
-
-
Manually annotated by BRENDA team
plasmid encoded enzyme
-
-
Manually annotated by BRENDA team
plasmid-encoded, pBC1e, beta-lactamase ACT-1; plasmid-encoded, pBC2e, beta-lactamase MIR-1; plasmid-encoded, pBC3e, beta-lactamase CMY-1; plasmid-encoded, pBC4e, beta-lactamase CMY-2
-
-
Manually annotated by BRENDA team
strain DH5alpha
-
-
Manually annotated by BRENDA team
strain HB101; strain JM105
-
-
Manually annotated by BRENDA team
strain HKY28
SwissProt
Manually annotated by BRENDA team
strain JM101
-
-
Manually annotated by BRENDA team
strain JM109, class C enzyme AmpC
UniProt
Manually annotated by BRENDA team
strain JM83
-
-
Manually annotated by BRENDA team
strain PEY
-
-
Manually annotated by BRENDA team
strain RB791
-
-
Manually annotated by BRENDA team
strain TUM1121
-
-
Manually annotated by BRENDA team
strain W3310
-
-
Manually annotated by BRENDA team
Escherichia coli DH5alpha
strain DH5alpha
-
-
Manually annotated by BRENDA team
Escherichia coli E384
E384
UniProt
Manually annotated by BRENDA team
Escherichia coli HKY28
strain HKY28
SwissProt
Manually annotated by BRENDA team
Escherichia coli JM101
strain JM101
-
-
Manually annotated by BRENDA team
Escherichia coli JM105
strain JM105
-
-
Manually annotated by BRENDA team
Escherichia coli JM109
strain JM109, class C enzyme AmpC
UniProt
Manually annotated by BRENDA team
Escherichia coli JM83
strain JM83
-
-
Manually annotated by BRENDA team
Escherichia coli PEY
strain PEY
-
-
Manually annotated by BRENDA team
Escherichia coli RB791
strain RB791
-
-
Manually annotated by BRENDA team
Escherichia coli TUM1121
strain TUM1121
-
-
Manually annotated by BRENDA team
Escherichia coli W3310
strain W3310
-
-
Manually annotated by BRENDA team
Fusobacterium nucleatum polymorphum strain NI61; subsp. polymorphum NI61
SwissProt
Manually annotated by BRENDA team
Fusobacterium nucleatum F21
strain F21
-
-
Manually annotated by BRENDA team
class A enzyme SHV-1
-
-
Manually annotated by BRENDA team
class A enzyme SHV-1
SwissProt
Manually annotated by BRENDA team
IMP-1 producing strains KPN1 and KPN2
-
-
Manually annotated by BRENDA team
isolates from Colombian hospitals
-
-
Manually annotated by BRENDA team
strain 15571, class A enzyme SHV-1
SwissProt
Manually annotated by BRENDA team
strain 2873
-
-
Manually annotated by BRENDA team
strain CHAK36
UniProt
Manually annotated by BRENDA team
the recombinant plasmid pVT-1 is used as a source of the blaOXA-48 gene. The blaOXA-48 ORF is subcloned into expression vector pET-9a to yield recombinant plasmid pET-OXA-48. Escherichia coli MCT236(DE3) is used as the host for overproduction of the OXA-48 enzyme
UniProt
Manually annotated by BRENDA team
Klebsiella pneumoniae 15571
strain 15571, class A enzyme SHV-1
SwissProt
Manually annotated by BRENDA team
Klebsiella pneumoniae 2873
strain 2873
-
-
Manually annotated by BRENDA team
Klebsiella pneumoniae CHAK36
strain CHAK36
UniProt
Manually annotated by BRENDA team
strain 68
-
-
Manually annotated by BRENDA team
Kluyvera ascorbata 68
strain 68
-
-
Manually annotated by BRENDA team
strain 1510
-
-
Manually annotated by BRENDA team
strain A209
-
-
Manually annotated by BRENDA team
strain GN5407
-
-
Manually annotated by BRENDA team
strain No. 14337
-
-
Manually annotated by BRENDA team
strain PP19
SwissProt
Manually annotated by BRENDA team
strain PP29
SwissProt
Manually annotated by BRENDA team
strain PP37
SwissProt
Manually annotated by BRENDA team
Morganella morganii 1510
strain 1510
-
-
Manually annotated by BRENDA team
Morganella morganii A209
strain A209
-
-
Manually annotated by BRENDA team
Morganella morganii GN5407
strain GN5407
-
-
Manually annotated by BRENDA team
Morganella morganii No. 14337
strain No. 14337
-
-
Manually annotated by BRENDA team
Morganella morganii PP19
strain PP19
SwissProt
Manually annotated by BRENDA team
Morganella morganii PP29
strain PP29
SwissProt
Manually annotated by BRENDA team
Morganella morganii PP37
strain PP37
SwissProt
Manually annotated by BRENDA team
; chromosomally encoded enzyme
Uniprot
Manually annotated by BRENDA team
no activity in Enterobacter agglomerans
no extended-spectrum beta-lactamase
-
-
Manually annotated by BRENDA team
no activity in Enterobacter asburiae
no extended-spectrum beta-lactamase
-
-
Manually annotated by BRENDA team
no activity in Enterobacter cloacae
no extended-spectrum beta-lactamase
-
-
Manually annotated by BRENDA team
no activity in Enterobacter gergoviae
no extended-spectrum beta-lactamase
-
-
Manually annotated by BRENDA team
no activity in Enterobacter sakazakii
no extended-spectrum beta-lactamase
-
-
Manually annotated by BRENDA team
subsp. atroseptica DSM 30184 (also recently named Pectobacterium atrosepticum)
UniProt
Manually annotated by BRENDA team
plasmid pBC
vector SK(+)-blaKPC-2
-
-
Manually annotated by BRENDA team
plasmid pBG66
contains the wild-type blaTEM-1 gene, expressed in Escherichia coli
-
-
Manually annotated by BRENDA team
plasmid pGEM-T-easy
-
-
-
Manually annotated by BRENDA team
plasmid pQE32Chl17
the chloramphenicol acetyltransferase gene replaces the blaTEM-1 gene as the selectable marker, allowing plasmid maintenance using 0.0125 mg/ml chloramphenicol. The blaTEM-1 gene is then subcloned under control of the IPTG-inducible promoter and mutated. The resulting constructs harbor a 6-histidine tag that is N-terminal to the native TEM-1 signal peptide. Upon processing of the signal peptide during expression and maturation in Escherichia coli, the histidine tag is also removed
-
-
Manually annotated by BRENDA team
12 multidrug-resistant Pseudomonas aeruginosa, MDRPA, isolates isolated in the National Bone Marrow Transplant Centre of Tunisia, genes blaSHV-1 and blaOXA-18
-
-
Manually annotated by BRENDA team
19 strains isolated from seven immunocompromised patients, and 3 strains isolated from environmental swabs, genes blaOXA18 and blaSHV
-
-
Manually annotated by BRENDA team
30 different samples solated from humans in Greece
-
-
Manually annotated by BRENDA team
an isolate from Turkey co-expressing extended-spectrum beta-lactamase PER-1 and metallo-beta-lactamase VIM-2, strain YUS, genes blaPER-1 and blaVIM-2
-
-
Manually annotated by BRENDA team
beta-lactamase PSE-1; genes blaPSE-1
UniProt
Manually annotated by BRENDA team
class A enzyme PSE-4, the active site structure involves Ser70, Lys73, Ser130, Glu166, Asn170, and Arg234 as catalytic residues
Uniprot
Manually annotated by BRENDA team
class D beta-lactamase
P14489
Uniprot
Manually annotated by BRENDA team
clinical human isolates from a Mexican tertiary-care hospital, strain 4677, gene blaVIM-1
-
-
Manually annotated by BRENDA team
clinical human isolates from Japan
-
-
Manually annotated by BRENDA team
clinical human isolates from Majorca, Spain, e.g. strain PA-SL2, and strain PAO1, genes blaVIM-1 and blaVIM-13
-
-
Manually annotated by BRENDA team
clinical human isolates from Rouen, France
-
-
Manually annotated by BRENDA team
clinical human isolates of imipenem-resistant strains, genes blaIMP-1, blaVIM and blaVIM-2
-
-
Manually annotated by BRENDA team
clinical isolate 51170
SwissProt
Manually annotated by BRENDA team
clinical isolates from human patients, gene bla-VIM in MBl variant VIM-2
-
-
Manually annotated by BRENDA team
cluster B Italian isolates; genes blaVIM-1 and bla-VIM-2
-
-
Manually annotated by BRENDA team
diverse strains and genes, overview
-
-
Manually annotated by BRENDA team
gene blaIMP-1; blaIMP-cluster-producingstrains
UniProt
Manually annotated by BRENDA team
gene blaVIM
-
-
Manually annotated by BRENDA team
genes blaVIM and blaIMP
-
-
Manually annotated by BRENDA team
IMP-10; gene blaIMP-10
UniProt
Manually annotated by BRENDA team
IMP-15; clinical human isolates from a Mexican tertiary-care hospital, strain 4677, gene blaIMP-15
UniProt
Manually annotated by BRENDA team
isolates from cystic fibrosis patients from Portugal
-
-
Manually annotated by BRENDA team
isolates from Korean human individuals, genes blaOXA-10, blaVIM-2, blaPSE-I, blaOXA-4, blaOXA-17, blaOXA-30
-
-
Manually annotated by BRENDA team
metallo-beta-lactamase VIM-7; isolate from the USA, gene blaVIM-7
UniProt
Manually annotated by BRENDA team
MSC15369, IMP-1 is PCR amplified from plasmid DNA prepared from a carbapenems-resistant Pseudomonas aeruginosa MSC15369. The PCR product is cloned into pTrcHis2 TOPO vector (Invitrogen, Carlsbad, CA) and expressed in Escherichia coli DH5a after induction with 0.5 mM isopropyl-beta-D-(-)-thiogalactopyranoside for 3 h at room temperature
-
-
Manually annotated by BRENDA team
OXA-2; gene blaOXA-2
UniProt
Manually annotated by BRENDA team
SL2
Q2HY42, Q9XAY4
UniProt
Manually annotated by BRENDA team
strain ATCC 27853, IMP-1 producing strains 131, 144, 137, 98, 128, 130, 143, 145, 183, PSA320, IMP-13 producing strain 86-10079, IMP-16 producing strain 101-4704, IMP-18 producing strains 3486 and 3489, GIM-1 producing strain 73-5671, VIM-1 producing strain 179, VIM-2 producing strain 225 and VIM-7 producing strain 07-406, SPM-1 producing strains 48-1997 A, 14, 44, 73, 75, 76, 83, 194, 196 and 197
-
-
Manually annotated by BRENDA team
strain Cl5673; strain Dalgleish
-
-
Manually annotated by BRENDA team
strain Dalgleish
-
-
Manually annotated by BRENDA team
strain Dalgleish; strain GN10362
-
-
Manually annotated by BRENDA team
strain Dalgleish; strain PU21 R151
-
-
Manually annotated by BRENDA team
strain Dalgleish; strain PU21 RPL11
-
-
Manually annotated by BRENDA team
strain M5109
-
-
Manually annotated by BRENDA team
strain PAO1, gene blaIMP
-
-
Manually annotated by BRENDA team
strains P15 and P23, 2 imipenem-resistant isolates, gene oxa40 coding on a plasmid
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa blaIMP-cluster-producingstrains
gene blaIMP-1; blaIMP-cluster-producingstrains
UniProt
Manually annotated by BRENDA team
Pseudomonas aeruginosa Cl5673
strain Cl5673
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa Dalgleish
strain Dalgleish
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa GN10362
strain GN10362
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa M5109
strain M5109
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa PS297
-
UniProt
Manually annotated by BRENDA team
Pseudomonas aeruginosa PU21 R151
strain PU21 R151
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa PU21 RPL11
strain PU21 RPL11
-
-
Manually annotated by BRENDA team
Pseudomonas aeruginosa SL2
SL2
Q2HY42, Q9XAY4
UniProt
Manually annotated by BRENDA team
strain TAE4
Uniprot
Manually annotated by BRENDA team
Pseudomonas fluorescens TAE4
strain TAE4
Uniprot
Manually annotated by BRENDA team
enzyme is encoded by Tn1332
SwissProt
Manually annotated by BRENDA team
IMP-1 producing strain 48-12346A
-
-
Manually annotated by BRENDA team
Psychrobacter immobilis A5
strain A5
-
-
Manually annotated by BRENDA team
strain CUV
-
-
Manually annotated by BRENDA team
strain UTAD54
-
-
Manually annotated by BRENDA team
strain UTAD54. the blaSFC-1 gene is contained in the chromosome of Serratia fonticola UTAD54 and is absent from other Serratia fonticola strains
SwissProt
Manually annotated by BRENDA team
Serratia fonticola CUV
strain CUV
-
-
Manually annotated by BRENDA team
strain UTAD54
-
-
Manually annotated by BRENDA team
Serratia fonticola UTAD54.
strain UTAD54. the blaSFC-1 gene is contained in the chromosome of Serratia fonticola UTAD54 and is absent from other Serratia fonticola strains
SwissProt
Manually annotated by BRENDA team
class A enzyme SME-1
-
-
Manually annotated by BRENDA team
IMP-1 producing strain SM319
-
-
Manually annotated by BRENDA team
clinical isolate KB-1
SwissProt
Manually annotated by BRENDA team
strain UIH-1
UniProt
Manually annotated by BRENDA team
Shigella sonnei UIH-1
strain UIH-1
UniProt
Manually annotated by BRENDA team
strain PC1
-
-
Manually annotated by BRENDA team
strain PC1; strains PC11, 22260, V137, FAR8, FAR10
-
-
Manually annotated by BRENDA team
Staphylococcus aureus PC1
strain PC1
-
-
Manually annotated by BRENDA team
metallo-beta-lactamase L1
UniProt
Manually annotated by BRENDA team
Stenotrophomonas maltophilia KJ
KJ
UniProt
Manually annotated by BRENDA team
strain G
-
-
Manually annotated by BRENDA team
strain antibioticus T1718, beta-lactamase AME 1
-
-
Manually annotated by BRENDA team
strain E750-3
-
-
Manually annotated by BRENDA team
strain R39
-
-
Manually annotated by BRENDA team
Streptomyces sp. E750-3
strain E750-3
-
-
Manually annotated by BRENDA team
Streptomyces sp. R39
strain R39
-
-
Manually annotated by BRENDA team
using the template blaSHV-1 gene in the phagemid vector pBC SK(-), degeneration of oligonucleotides at Ambler position 276 to make the full complement of amino acid substitutions. After PCR mutagenesis, electroporation of the resultant plasmids into Escherichia coli
-
-
Manually annotated by BRENDA team
biovar 1A
SwissProt
Manually annotated by BRENDA team
biovar 1A; fragment; biovar 1A
SwissProt
Manually annotated by BRENDA team
precursor; strain Y56
UniProt
Manually annotated by BRENDA team
strain IP97; strain IP97. In the bla gene from strain IP97 a deletion of 51 bp results in a completely inactive beta-lactamase. In the ampC gene from strain Y56 the A751G mutation is responsible for the inactivation of beta-lactamase
-
-
Manually annotated by BRENDA team
Yersinia enterocolitica IP97
strain IP97
-
-
Manually annotated by BRENDA team
Yersinia enterocolitica Y56
precursor; strain Y56
UniProt
Manually annotated by BRENDA team
Bla-A, fragment; strain C-115
UniProt
Manually annotated by BRENDA team
Bla-B, fragment; strain C-115
UniProt
Manually annotated by BRENDA team
Yersinia frederiksenii C-115
Bla-A, fragment; strain C-115
UniProt
Manually annotated by BRENDA team
Yersinia frederiksenii C-115
Bla-B, fragment; strain C-115
UniProt
Manually annotated by BRENDA team
Bla-A, fragment; strain C-702
UniProt
Manually annotated by BRENDA team
Bla-B, fragment; strain C-702
UniProt
Manually annotated by BRENDA team
Yersinia intermedia C-702
Bla-A, fragment; strain C-702
UniProt
Manually annotated by BRENDA team
Yersinia intermedia C-702
Bla-B, fragment; strain C-702
UniProt
Manually annotated by BRENDA team
strain 1006/94
SwissProt
Manually annotated by BRENDA team
Yersinia ruckeri 1006/94
strain 1006/94
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
physiological function
-
plays a significant role in limiting susceptibility to penicillins and cephalosporins. The contribution of BlaB, a class C enzyme, is less profound and is limited primarily to cephalosporin susceptibility
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(6R,7R)-3-[(acetyloxy)methyl]-7-(formylamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy(formylamino)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-
-
-
-
?
(6R,7R)-3-[(acetyloxy)methyl]-7-(hydroxyamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy(hydroxyamino)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-
-
-
-
?
(6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-amino(carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-
-
-
-
?
(6R,7R)-3-[(acetyloxy)methyl]-7-[formyl(hydroxy)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[formyl(hydroxy)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-
-
-
-
?
(6R,7R)-3-[(acetyloxy)methyl]-7-[hydroxy(phenylacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[hydroxy(phenylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-
-
-
-
?
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-
-
-
-
?
(6R,7S)-3-[(3-carboxy-4-nitro-phenyl)sulfanylmethyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo-[4.2.0]-oct-2-ene-2-carboxylic acid + H2O
?
show the reaction diagram
P13661
-
-
-
?
(6R,7Z)-3-[(acetyloxy)methyl]-7-(hydroxyimino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(Z)-carboxy(hydroxyimino)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-
-
-
-
?
(6R,7Z)-7-(hydroxyimino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5,5-dioxide + H2O
(2R)-2-[(Z)-carboxy(hydroxyimino)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylate 1,1-dioxide
show the reaction diagram
-
-
-
-
?
(7R)-7-(benzyloxycarbonylamino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O
?
show the reaction diagram
Enterobacter cloacae, Enterobacter cloacae P99
-
-
-
-
?
(7S)-7-(benzyloxycarbonylamino)-3-methyl-8-thioxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O
?
show the reaction diagram
Enterobacter cloacae, Enterobacter cloacae P99
-
is 1000000times poorer (kcat and kcat/Km) as a substrate than (7R)-7-(benzyloxycarbonylamino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
-
?
2-(2-(2-phenylacetamido)acetoxy)acetate + H2O
?
show the reaction diagram
Enterobacter cloacae, Enterobacter cloacae P99
-
-
-
-
?
2-(2-(2-phenylacetamido)ethanethioyloxy)acetate + H2O
?
show the reaction diagram
-
2-(2-(2-phenylacetamido)ethanethioyloxy)acetate is much poorer a substrate than 2-(2-(2-phenylacetamido)acetoxy)acetate
-
-
?
2-azabicyclo[2.2.1]hept-5-en-3-one + H2O
(-)-2-azabicyclo[2.2.1]hept-5-en-3-one + (+)-4-amino-cyclopent-2-enecarboxylic acid
show the reaction diagram
-
-
-
-
-
2-azabicyclo[2.2.1]hept-5-en-3-one + H2O
(+)-2-azabicyclo[2.2.1]hept-5-en-3-one + (-)-4-amino-cyclopent-2-enecarboxylic acid
show the reaction diagram
-
-
-
-
-
3-(2-(2-phenylacetamido)acetoxy)benzoate + H2O
?
show the reaction diagram
-
-
-
-
?
3-([3-dibenzylamino-3-oxopropanoyl]oxy)benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
3-([3-[benzyl(methyl)amino]-3-oxopropanoyl]oxy)benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
3-([N-(phenylacetyl)glycyl]oxy)benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
3-([N-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]glycyl]oxy)benzoic acid + H2O
?
show the reaction diagram
-
GC1 beta-lactamase, P99 beta-lactamase
-
-
?
3-([[(2R)-3-(benzylamino)-2-methoxy-3-oxopropanoyl]oxy]methyl)benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
3-([[(2R)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
3-([[(2S)-3-(benzylamino)-2-methoxy-3-oxopropanoyl]oxy]methyl)benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
3-([[(2S)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
3-([[2-benzyl-3-oxo-3-(benzylamino)propanoyl]oxy]methyl)benzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
3-nitrophenyl (2S)-2-hydroxy-3-phenylpropanoate + H2O
?
show the reaction diagram
P05364
-
-
-
?
3-[2-(2-aminothiazol-4-yl)2-(Z)-methoxyiminoacetylglycyl]oxybenzoic acid + H2O
?
show the reaction diagram
-
-
-
-
?
3-[[(2S)-2-hydroxy-3-phenylpropanoyl]oxy]benzoic acid + H2O
?
show the reaction diagram
P05364
-
-
-
?
4beta-methoxy-trinem + H2O
?
show the reaction diagram
Enterobacter cloacae, Enterobacter cloacae P99
-
-
-
-
?
6-aminopenicillanic acid + H2O
?
show the reaction diagram
-
-
-
-
-
6-aminopenicillanic acid + H2O
?
show the reaction diagram
-
-
-
-
?
6-aminopenicillanic acid + H2O
?
show the reaction diagram
-
-
-
-
?
6-aminopenicillanic acid + H2O
?
show the reaction diagram
Escherichia coli JM101
-
-
-
-
-
6-aminopenicillanic acid + H2O
?
show the reaction diagram
Bacillus licheniformis 749/C, Bacillus licheniformis 6346/C
-
-
-
-
?
6-beta-iodopenicillanate
?
show the reaction diagram
-
-
-
-
?
7-(thienyl-2-acetamido)-3-[2-(4-,N,N-dimethylaminophenylazo)pyridinium-methyl]-3-cephem-4-carboxylic acid + H2O
?
show the reaction diagram
-
i.e. PADAC
-
-
?
7-(thienyl-2-acetamido)-3-[2-(4-N,N-dimethylaminophenylazo)pyridinium-methyl]-3-cephem-4-carboxylic acid + H2O
?
show the reaction diagram
-
-
-
-
-
7-(thienyl-2-acetamido)-3-[2-(4-N,N-simethylaminophenylazo)pyridinium-methyl]-3-cephem-4-carboxylic acid + H2O
?
show the reaction diagram
Enterobacter cloacae, Enterobacter cloacae P99
-
chromophoric substrate
-
-
?
7-beta-formamidoyl-7-alpha-methoxycephalosporanic acid + H2O
?
show the reaction diagram
-, P00808
-
-
-
?
7alpha-aminocephalosporanic acid + H2O
?
show the reaction diagram
Enterobacter cloacae, Enterobacter cloacae P99
Q59401
-
-
-
?
7beta-aminocephalosporanic acid + H2O
?
show the reaction diagram
-
-
-
-
?
7beta-aminocephalosporanic acid + H2O
?
show the reaction diagram
Q59401
-
-
-
-
7beta-aminocephalosporanic acid + H2O
?
show the reaction diagram
Enterobacter cloacae P99
-
-
-
-
?
7beta-aminocephalosporanic acid + H2O
?
show the reaction diagram
Enterobacter cloacae P99
Q59401
-
-
-
-
7beta-[(thien-2-yl)acetamido]-3-[(4-nitro-3-carboxyphenylthio)methyl]-3-cephem-4-carboxylic acid + H2O
?
show the reaction diagram
-
-
-
-
?
a beta-lactam + H2O
a substituted beta-amino acid
show the reaction diagram
Q8GCU7
-
-
-
?
Amoxicillin + H2O
?
show the reaction diagram
-
-
-
-
?
Amoxicillin + H2O
?
show the reaction diagram
-, Q708V3, Q708V4, Q8RNV0, Q9AL74
-
-
-
?
Amoxicillin + H2O
?
show the reaction diagram
Q3SAW3
-
-
-
?
Amoxicillin + H2O
?
show the reaction diagram
Q20I87
-
-
-
?
Amoxicillin + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
-
-
-
?
Amoxicillin + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
Amoxicillin + H2O
?
show the reaction diagram
Q4TVR4
-
-
-
?
amoxicillin + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
-, Q670S6
-
-
-
?
amoxicillin + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
-, I6S7G0
-
-
-
-
amoxycillin + H2O
?
show the reaction diagram
-
-
-
-
?
amoxycillin + H2O
?
show the reaction diagram
-
-
-
-
?
amoxycillin + H2O
?
show the reaction diagram
-
-
-
-
?
amoxycillin + H2O
?
show the reaction diagram
-
-
-
-
?
amoxycillin + H2O
?
show the reaction diagram
-
beta-lactamase A
-
-
?
amoxycillin + H2O
?
show the reaction diagram
Serratia fonticola CUV
-
-
-
-
?
amoxycillin + H2O
?
show the reaction diagram
Enterobacter cloacae NOR-1
-
-
-
-
?
amoxycillin + H2O
?
show the reaction diagram
Escherichia coli PEY
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
-
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
P05364
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
P85302
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
P16897
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q2HY42, Q9XAY4
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
-
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
P52700
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q7WZ37
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q6VCW0, -
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-, Q6PL88
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q76DI4
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q704U4
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-, Q5I2N2
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q4ZE97
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-, Q6XL56
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q704Y9, Q704Z0, Q705J0
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-, Q6T3Q5
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-, Q5MJG5
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q5QT35
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q8GIW8
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q6JE29
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-, Q0VJU2
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q50H31
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
A5LH21, -
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
P13661
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
B8R6A5, C1J897, C1J899, C1J8A0
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
A8R403
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-, Q6D395
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q1KY81
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
plasmid pBG66
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
low activity
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
beta-lactamase A
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
9% relative activity to cephaloridine
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
beta-lactamase III
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
38% relative activity to benzylpenicillin
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q8KSA6
beta-lactamases CTX-M-25
-
-
?
ampicillin + H2O
?
show the reaction diagram
Q8GD10
beta-lactamases CTX-M-26
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
plasmid-encoded, pBC1e, beta-lactamase ACT-1, plasmid-encoded, pBC2e, beta-lactamase MIR-1, plasmid-encoded, pBC3e, beta-lactamase CMY-1, plasmid-encoded, pBC4e, beta-lactamase CMY-2
-
-
?
ampicillin + H2O
?
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Enterobacter aerogenes 1082E
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Morganella morganii PP29
Q704Z0
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Escherichia coli DH5alpha
-
-
-
-
-
ampicillin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa M5109
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Enterobacter aerogenes SS-13
Q1KY81
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Streptomyces sp. R39
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Escherichia coli JM83
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Psychrobacter immobilis A5
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Shigella sonnei UIH-1
A5LH21
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Aeromonas sobria 163a
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Kluyvera ascorbata 68
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa Dalgleish
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa PU21 R151
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Escherichia coli HKY28
Q76DI4
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Bacillus cereus 569/H/9
-
beta-lactamase III
-
-
?
ampicillin + H2O
?
show the reaction diagram
Bacillus cereus 569/H/9
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Bacillus cereus 569/H/9
-
-
-
-
-, ?
ampicillin + H2O
?
show the reaction diagram
Brachyspira pilosicoli BM4442
Q50H31
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Morganella morganii 1510
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Bacillus cereus 5/B
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Citrobacter koseri VAN
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Escherichia coli JM101
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Morganella morganii PP19
Q705J0
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Morganella morganii PP37
Q704Y9
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Bacillus sp. No. 170
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Acinetobacter baylyi ADP1
Q0VJU2
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Citrobacter freundii GN7391
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Aeromonas sobria AER14M
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Staphylococcus aureus PC1
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Streptomyces sp. E750-3
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa PU21 RPL11
-
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa SL2
Q2HY42, Q9XAY4
-
-
-
?
ampicillin + H2O
?
show the reaction diagram
Clostridium butyricum CB269
-
-
-
-
?
ampicillin + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
Q6XEC0
-
-
-
?
ampicillin + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
-
-
-
-
?
ampicillin + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
-, B2BSN6
-
-
-
?
ampicillin + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
plasmid pGEM-T-easy
-
-
-
-
?
ampicillin + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
E7BCS7
-
-
-
?
ampicillin + H2O + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
Q7WYA8
-
-
-
?
ampicillin + H2O + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
-, Q8KQ59
-
-
-
?
ampicillin + H2O + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
Q5U807
-
-
-
?
ampicillin + H2O + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
Q9RMI1, -
-
-
-
?
ampicillin + H2O + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
Q8KRJ3
-
-
-
?
ampicillin + H2O + H2O
(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
-, I6S7G0
-
-
-
?
azlocillin + H2O
?
show the reaction diagram
-
-
-
-
?
azlocillin + H2O
?
show the reaction diagram
-, Q59517
-
-
-
?
azlocillin + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
azlocillin + H2O
?
show the reaction diagram
-
beta-lactamase A
-
-
?
aztreonam + H2O
?
show the reaction diagram
-
-
-
-
-
aztreonam + H2O
?
show the reaction diagram
-
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
-
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
-, Q708V3, Q708V4, Q8RNV0, Q9AL74
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
-
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
-
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
-
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Q3SAW3
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Q4TVR4
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
B8R6A5, C1J897, C1J899, C1J8A0
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Q1KY81
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Q8KSA6
beta-lactamases CTX-M-25
-
-
?
aztreonam + H2O
?
show the reaction diagram
Q8GD10
beta-lactamases CTX-M-26
-
-
?
aztreonam + H2O
?
show the reaction diagram
-
poorly active against ceftazidime and aztreonam
-
-
?
aztreonam + H2O
?
show the reaction diagram
-
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Enterobacter aerogenes SS-13
Q1KY81
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Citrobacter koseri CK4
-
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Escherichia coli JM83
-
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Kluyvera ascorbata 68
-
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Serratia fonticola CUV
-
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Enterobacter cloacae NOR-1
-
-
-
-
?
aztreonam + H2O
?
show the reaction diagram
Escherichia coli TUM1121
-
poorly active against ceftazidime and aztreonam
-
-
?
aztreonam + H2O
?
show the reaction diagram
Bacillus clausii NR
A8RR46
-
-
-
?
aztreonam + H2O
[(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
show the reaction diagram
-, Q670S6
-
-
-
?
aztreonam + H2O
[(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
show the reaction diagram
E7BCS7
-
-
-
?
aztreonam + H2O
[(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
show the reaction diagram
-, Q8KQ59
-
-
-
?
benzyl [[(2R)-2-hydroxy-3-phenylpropanoyl]oxy]carbamate + H2O
? + hydroxamate
show the reaction diagram
P05364
-
-
-
?
benzyl [[(2S)-2-hydroxy-2-phenylacetyl]oxy]carbamate + H2O
? + hydroxamate
show the reaction diagram
P05364
-
-
-
?
benzyl [[(2S)-2-hydroxy-3-phenylpropanoyl]oxy]carbamate + H2O
? + hydroxamate
show the reaction diagram
P05364
-
-
-
?
benzyl [[(2S)-2-hydroxy-4-phenylbutanoyl]oxy]carbamate + H2O
? + hydroxamate
show the reaction diagram
P05364
-
-
-
?
benzyl [[(2S)-2-hydroxypropanoyl]oxy]carbamate + H2O
? + hydroxamate
show the reaction diagram
P05364
-
-
-
?
benzylcephalosporin C + H2O
?
show the reaction diagram
Bacillus licheniformis, Bacillus licheniformis 749/C, Bacillus licheniformis 6346/C
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
P05364
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
P85302
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
P52699
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
P04190
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
-
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q708V3, Q708V4, Q8RNV0, Q9AL74
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-, Q59517
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
-
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q6VCW0, -
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-, Q6PL88
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q3SAW3
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-, Q5I2N2
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-, Q6XL56
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q704Y9, Q704Z0, Q705J0
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q20I87
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q6JE29
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-, B3FIE3
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q09HD0
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q50H31
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
B8R6A5, C1J897, C1J899, C1J8A0
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q1KY81
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
best substrate
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
beta-lactamase A
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
beta-lactamase III
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
3% relative activity to cephaloridine
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
100% relative activity to other substrates tested
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-, Q6GVZ4
2.8% of the activity with cephaloridine
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
670% of the activity with amoxicillin
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q8KSA6
beta-lactamases CTX-M-25
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Q8GD10
beta-lactamases CTX-M-26
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
-
plasmid-encoded, pBC1e, beta-lactamase ACT-1, plasmid-encoded, pBC2e, beta-lactamase MIR-1, plasmid-encoded, pBC3e, beta-lactamase CMY-1, plasmid-encoded, pBC4e, beta-lactamase CMY-2
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Enterobacter aerogenes 1082E
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Morganella morganii PP29
Q704Z0
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Escherichia coli DH5alpha
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa M5109
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Enterobacter aerogenes SS-13
Q1KY81
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Citrobacter koseri CK4
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Streptomyces sp. R39
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Enterobacter cloacae P99
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Psychrobacter immobilis A5
-
-
-
-
-
benzylpenicillin + H2O
?
show the reaction diagram
Aeromonas sobria 163a
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Kluyvera ascorbata 68
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa Dalgleish
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Serratia fonticola CUV
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Escherichia coli RB791
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Klebsiella pneumoniae CHAK36
Q09HD0
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Bacillus cereus 569/H/9
-
beta-lactamase III
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Bacillus cereus 569/H/9
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Brachyspira pilosicoli BM4442
Q50H31
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Enterobacter cloacae NOR-1
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Bacillus cereus 5/B
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Citrobacter koseri VAN
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Escherichia coli JM105
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Escherichia coli JM101
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Morganella morganii PP19
Q705J0
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Morganella morganii PP37
Q704Y9
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Escherichia coli TUM1121
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Achromobacter xylosoxidans CIP69598
B3FIE3
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Bacillus licheniformis 749/C
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Aeromonas sobria AER14M
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Staphylococcus aureus PC1
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Yersinia ruckeri 1006/94
Q20I87
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Escherichia coli PEY
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Bacillus clausii NR
A8RR46
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Morganella morganii GN5407
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Bacillus licheniformis 6346/C
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Streptomyces sp. E750-3
-
-
-
-
?
benzylpenicillin + H2O
?
show the reaction diagram
Clostridium butyricum CB269
-
-
-
-
?
benzylpenicillin + H2O
(2R,4S)-2-[(R)-carboxy[(phenylacetyl)amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
plasmid pQE32Chl17
-
-
-
-
?
benzylpenicillin + H2O
(2R,4S)-2-[(R)-carboxy[(phenylacetyl)amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
plasmid pGEM-T-easy
-
-
-
-
?
benzylpenicillin + H2O
(2R,4S)-2-[(R)-carboxy[(phenylacetyl)amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
Q5U807
-
-
-
?
benzylpenicillin + H2O
(2R,4S)-2-[(R)-carboxy[(phenylacetyl)amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
Q8KRJ3
-
-
-
?
benzylpenicillin + H2O
(2R,4S)-2-[(R)-carboxy[(phenylacetyl)amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
-, I6S7G0
-
-
-
?
benzylpenicillin + H2O
(2R,4S)-2-[(R)-carboxy[(phenylacetyl)amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
Pseudomonas aeruginosa PS297
Q5U807
-
-
-
?
biapenem + H2O
?
show the reaction diagram
-
-
-
-
?
biapenem + H2O
?
show the reaction diagram
P26918
-
-
-
?
biapenem + H2O
?
show the reaction diagram
-
-
-
-
?
biapenem + H2O
?
show the reaction diagram
P52700
-
-
-
?
biapenem + H2O
?
show the reaction diagram
-
-
-
-
?
biapenem + H2O
?
show the reaction diagram
-
-
-
-
?
biapenem + H2O
?
show the reaction diagram
Q8KRJ3
-
-
-
?
biapenem + H2O
?
show the reaction diagram
-
activity in resistant strains
-
-
?
biapenem + H2O
?
show the reaction diagram
Aeromonas sobria AER14M
-
-
-
-
?
carbapenem + H2O
?
show the reaction diagram
-
-
-
-
?
carbapenem + H2O
?
show the reaction diagram
-
-
-
-
?
carbapenem + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
carbapenem + H2O
?
show the reaction diagram
-
-
-
-
?
carbencillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
P05364
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
P85302
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
P16897
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-, Q59517
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Q704U4
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-, Q6T3Q5
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-, Q5MJG5
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Q8GIW8
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Q6JE29
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Q50H31
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Q9RMI1, -
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Q8KRJ3
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
low hydrolysis rate
-
-
?
carbenicillin + H2O
?
show the reaction diagram
-
66% relative activity to benzylpenicillin
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Q9RMI1
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Escherichia coli DH5alpha
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Aeromonas sobria 163a
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa Dalgleish
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa PU21 R151
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Bacillus cereus 569/H/9
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Brachyspira pilosicoli BM4442
Q50H31
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Citrobacter koseri VAN
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Bacillus sp. No. 170
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Citrobacter freundii GN7391
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Aeromonas sobria AER14M
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Streptomyces sp. E750-3
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa PU21 RPL11
-
-
-
-
?
carbenicillin + H2O
?
show the reaction diagram
Clostridium butyricum CB269
-
-
-
-
?
cefaclor + H2O
?
show the reaction diagram
-
-
-
-
?
cefaclor + H2O
?
show the reaction diagram
-
-
-
-
?
cefaclor + H2O
?
show the reaction diagram
-
-
-
-
?
cefaclor + H2O
?
show the reaction diagram
P52700
-
-
-
?
cefadroxil + H2O
?
show the reaction diagram
-
-
-
-
?
cefaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cefaloridine + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
25% of the activity with amoxicillin
-
-
?
cefaloridine + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
3% of the activity with amoxicillin
-
-
?
cefalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cefalothin + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
cefalothin + H2O
?
show the reaction diagram
A1EGT8
-
-
-
?
cefalothin + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
3% of the activity with amoxicillin
-
-
?
cefalothin + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
8% of the activity with amoxicillin
-
-
?
cefalotin + H2O
?
show the reaction diagram
Q01166, -
-
-
-
?
cefalotin + H2O
?
show the reaction diagram
-, Q0VJU2
-
-
-
?
cefalotin + H2O
?
show the reaction diagram
P28585
-
-
-
?
cefalotin + H2O
?
show the reaction diagram
Yersinia enterocolitica Y56
Q01166
-
-
-
?
cefalotin + H2O
?
show the reaction diagram
Acinetobacter baylyi ADP1
Q0VJU2
-
-
-
?
cefalotin + H2O
?
show the reaction diagram
Yersinia enterocolitica IP97
-
-
-
-
?
cefamandole + H2O
?
show the reaction diagram
-
-
-
-
?
cefamandole + H2O
?
show the reaction diagram
-
-
-
-
?
cefamandole + H2O
?
show the reaction diagram
-
-
-
-
?
cefamandole + H2O
?
show the reaction diagram
-
-
-
-
?
cefamandole + H2O
?
show the reaction diagram
-
-
-
-
?
cefamandole + H2O
?
show the reaction diagram
-
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
-
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
-
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
P05364
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
P85302
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
-
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
-
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
-
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
-
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
-
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
Q6JE29
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
Q1KY81
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
-
plasmid-encoded, pBC1e, beta-lactamase ACT-1, plasmid-encoded, pBC2e, beta-lactamase MIR-1, plasmid-encoded, pBC3e, beta-lactamase CMY-1, plasmid-encoded, pBC4e, beta-lactamase CMY-2
-
-
?
cefazolin + H2O
?
show the reaction diagram
Enterobacter aerogenes SS-13
Q1KY81
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
Psychrobacter immobilis A5
-
-
-
-
?
cefazolin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa Dalgleish, Pseudomonas aeruginosa GN10362
-
-
-
-
?
cefazolin + H2O
(2R)-2-[(R)-carboxy[(1H-tetrazol-1-ylacetyl)amino]methyl]-5-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
plasmid pQE32Chl17
-
-
-
-
?
cefazolin + H2O
(2R)-2-[(R)-carboxy[(1H-tetrazol-1-ylacetyl)amino]methyl]-5-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, B2BSN6
-
-
-
?
cefcapene + H2O
?
show the reaction diagram
-
-
-
-
?
cefdinir + H2O
?
show the reaction diagram
-
-
-
-
?
cefepime + H2O
?
show the reaction diagram
-
-
-
-
?
cefepime + H2O
?
show the reaction diagram
-
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q2HY42, Q9XAY4
-
-
-
?
cefepime + H2O
?
show the reaction diagram
-
-
-
-
?
cefepime + H2O
?
show the reaction diagram
-
-
-
-
?
cefepime + H2O
?
show the reaction diagram
-
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q76DI4
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q704U4
-
-
-
?
cefepime + H2O
?
show the reaction diagram
-
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q3SAW3
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q4ZE97
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q704Y9, Q704Z0, Q705J0
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q20I87
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q8GIW8
-
-
-
?
cefepime + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q4TVR4
-
-
-
?
cefepime + H2O
?
show the reaction diagram
A5LH21, -
-
-
-
?
cefepime + H2O
?
show the reaction diagram
P13661
-
-
-
?
cefepime + H2O
?
show the reaction diagram
B8R6A5, C1J897, C1J899, C1J8A0
-
-
-
?
cefepime + H2O
?
show the reaction diagram
P00811
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Q1KY81
-
-
-
?
cefepime + H2O
?
show the reaction diagram
-, Q6GVZ4
1.05% of the activity with cephaloridine
-
-
?
cefepime + H2O
?
show the reaction diagram
Shigella sonnei UIH-1
A5LH21
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Escherichia coli HKY28
Q76DI4
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Escherichia coli TUM1121
-
-
-
-
?
cefepime + H2O
?
show the reaction diagram
Pseudomonas aeruginosa SL2
Q2HY42, Q9XAY4
-
-
-
?
cefepime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
Q6XEC0
-
-
-
?
cefepime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-, B2BSN6
-
-
-
?
cefepime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
Q7WYA8
-
-
-
?
cefepime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-, Q8KQ59
-
-
-
?
cefepime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
Q5U807
-
-
-
?
cefepime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
Q9RMI1, -
-
-
-
?
cefepime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
Q9RMI1
-
-
-
?
cefepime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
Pseudomonas aeruginosa PS297
Q5U807
-
-
-
?
cefmetazole + H2O
?
show the reaction diagram
-
-
-
-
?
cefoperazone + H2O
?
show the reaction diagram
-
-
-
-
?
cefoperazone + H2O
?
show the reaction diagram
-
-
-
-
-
cefoperazone + H2O
?
show the reaction diagram
-
-
-
-
?
cefoperazone + H2O
?
show the reaction diagram
-
-
-
-
?
cefoperazone + H2O
?
show the reaction diagram
-
-
-
-
?
cefoperazone + H2O
?
show the reaction diagram
-
11% relative activity to cephaloridine
-
-
?
cefoperazone + H2O
?
show the reaction diagram
Pseudomonas aeruginosa Dalgleish, Pseudomonas aeruginosa GN10362
-
-
-
-
?
cefoperazone + H2O
?
show the reaction diagram
Morganella morganii GN5407
-
-
-
-
-
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
-
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q2HY42, Q9XAY4
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-, Q708V3, Q708V4, Q8RNV0, Q9AL74
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-, Q59517
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q76DI4
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q704U4
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q3SAW3
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q4ZE97
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q704Y9, Q704Z0, Q705J0
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q20I87
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q8GIW8
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q6JE29
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q09HD0
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q4TVR4
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
A5LH21, -
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
P13661
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
A3RIY0
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
A1EGT8
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
P28585
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
B8R6A5, C1J897, C1J899, C1J8A0
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
P00811
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
A8R403
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-, Q6D395
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q1KY81
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
48% relative activity to cephaloridine
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
conformational restriction of the extended OMEGA loop in the enzyme is probably responsible for the long-living acyl-enzyme intermediate and transition effects of cefotaxime
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q8KSA6
beta-lactamases CTX-M-25
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Q8GD10
beta-lactamases CTX-M-26
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
GC1 beta-lactamase
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
plasmid-encoded, pBC1e, beta-lactamase ACT-1, plasmid-encoded, pBC2e, beta-lactamase MIR-1, plasmid-encoded, pBC3e, beta-lactamase CMY-1, plasmid-encoded, pBC4e, beta-lactamase CMY-2
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
poor substrate for P99 beta-lactamase
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-, Q59517
low specific activity
-
-
?
cefotaxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Morganella morganii PP29
Q704Z0
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Enterobacter aerogenes SS-13
Q1KY81
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Citrobacter koseri CK4
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Shigella sonnei UIH-1
A5LH21
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Escherichia coli RB791
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Escherichia coli HKY28
Q76DI4
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Klebsiella pneumoniae CHAK36
Q09HD0
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Enterobacter cloacae NOR-1
-
-
-
-
-
cefotaxime + H2O
?
show the reaction diagram
Morganella morganii PP19
Q705J0
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Morganella morganii PP37
Q704Y9
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Escherichia coli TUM1121
-
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Yersinia ruckeri 1006/94
Q20I87
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Pseudomonas aeruginosa SL2
Q2HY42, Q9XAY4
-
-
-
?
cefotaxime + H2O
?
show the reaction diagram
Escherichia coli E384
A3RIY0
-
-
-
?
cefotaxime + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q6XEC0
-
-
-
?
cefotaxime + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
plasmid pQE32Chl17
-
-
-
-
?
cefotaxime + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, B2BSN6
-
-
-
?
cefotaxime + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
plasmid pBC
-
-
-
-
?
cefotaxime + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, Q670S6
-
-
-
?
cefotaxime + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q7WYA8
-
-
-
?
cefotaxime + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, Q8KQ59
-
-
-
?
cefotaxime + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Pseudomonas aeruginosa, Pseudomonas aeruginosa PS297
Q5U807
-
-
-
?
cefotetan + H2O
?
show the reaction diagram
-
-
-
-
?
cefotiam + H2O
?
show the reaction diagram
-
-
-
-
?
cefotiam + H2O
?
show the reaction diagram
-
-
-
-
?
cefotiam + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-, P00808
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
-
cefoxitin + H2O
?
show the reaction diagram
P52700
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-, Q59517
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Q7WZ37
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Q76DI4
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Q704U4
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Q704Y9, Q704Z0, Q705J0
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Q20I87
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Q09HD0
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
A3RIY0
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
A1EGT8
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
B8R6A5, C1J897, C1J899, C1J8A0
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
P00811
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
A8R403
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-, Q6D395
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
plasmid-encoded, pBC1e, beta-lactamase ACT-1, plasmid-encoded, pBC2e, beta-lactamase MIR-1, plasmid-encoded, pBC3e, beta-lactamase CMY-1, plasmid-encoded, pBC4e, beta-lactamase CMY-2
-
-
?
cefoxitin + H2O
?
show the reaction diagram
-
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Morganella morganii PP29
Q704Z0
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Escherichia coli HKY28
Q76DI4
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Klebsiella pneumoniae CHAK36
Q09HD0
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Morganella morganii PP19
Q705J0
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Morganella morganii PP37
Q704Y9
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Yersinia ruckeri 1006/94
Q20I87
-
-
-
?
cefoxitin + H2O
?
show the reaction diagram
Escherichia coli E384
A3RIY0
-
-
-
?
cefoxitin + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q6XEC0
-
-
-
?
cefoxitin + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, B2BSN6
-
-
-
?
cefoxitin + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
E7BCS7
-
-
-
?
cefoxitin + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q7WYA8
-
-
-
?
cefoxitin + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q5U807
-
-
-
?
cefoxitin + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q9RMI1, -
-
-
-
?
cefoxitin + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q9RMI1
-
-
-
?
cefoxitin + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Pseudomonas aeruginosa PS297
Q5U807
-
-
-
?
cefpirome + H2O
?
show the reaction diagram
-
-
-
-
?
cefpirome + H2O
?
show the reaction diagram
-
-
-
-
?
cefpirome + H2O
?
show the reaction diagram
Q6VCW0, -
-
-
-
?
cefpirome + H2O
?
show the reaction diagram
Q76DI4
-
-
-
?
cefpirome + H2O
?
show the reaction diagram
Q20I87
-
-
-
?
cefpirome + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
cefpirome + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-(6,7-dihydro-5H-cyclopenta[b]pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-, B2BSN6
-
-
-
?
cefpodoxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefprozil + H2O
?
show the reaction diagram
-
-
-
-
?
cefsulodin + H2O
?
show the reaction diagram
-
-
-
-
?
cefsulodin + H2O
?
show the reaction diagram
-, Q6PL88
-
-
-
?
cefsulodine + H2O
?
show the reaction diagram
Q3SAW3
-
-
-
?
ceftaxidime + H2O
?
show the reaction diagram
Q09HD0
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q2HY42, Q9XAY4
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-, Q708V3, Q708V4, Q8RNV0, Q9AL74
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q6VCW0, -
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q76DI4
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q704U4
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q4ZE97
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q704Y9, Q704Z0, Q705J0
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q20I87
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q8GIW8
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q4TVR4
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
A5LH21, -
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
A1EGT8
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
B8R6A5, C1J897, C1J899, C1J8A0
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
P00811
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
A8R403
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-, Q6D395
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
5% of the activity with amoxicillin
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q8KSA6
beta-lactamases CTX-M-25
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q8GD10
beta-lactamases CTX-M-26
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
poorly active against ceftazidime and aztreonam
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Q1KY81
preferred and best substrate
-
-
?
ceftazidime + H2O
?
show the reaction diagram
A3RIY0
30C, pH 7.0. The affinity of MIR-4 beta-lactamase for ceftazidime is quite low
-
-
?
ceftazidime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Shigella sonnei UIH-1
A5LH21
-
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Escherichia coli TUM1121
-
poorly active against ceftazidime and aztreonam
-
-
?
ceftazidime + H2O
?
show the reaction diagram
Escherichia coli E384
A3RIY0
30C, pH 7.0. The affinity of MIR-4 beta-lactamase for ceftazidime is quite low
-
-
?
ceftazidime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
Q6XEC0
-
-
-
?
ceftazidime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-, B2BSN6
-
-
-
?
ceftazidime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-, Q670S6
-
-
-
?
ceftazidime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
E7BCS7
-
-
-
?
ceftazidime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
Q7WYA8
-
-
-
?
ceftazidime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-, Q8KQ59
-
-
-
?
ceftazidime + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino](carboxy)methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
Pseudomonas aeruginosa, Pseudomonas aeruginosa PS297
Q5U807
-
-
-
?
ceftizoxime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftizoxime + H2O
?
show the reaction diagram
-
-
-
-
?
ceftriaxone + H2O
?
show the reaction diagram
-
-
-
-
?
ceftriaxone + H2O
?
show the reaction diagram
-
-
-
-
?
ceftriaxone + H2O
?
show the reaction diagram
Q3SAW3
-
-
-
?
ceftriaxone + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
ceftriaxone + H2O
?
show the reaction diagram
-, Q6D395
-
-
-
?
ceftriaxone + H2O
?
show the reaction diagram
-
23% relative activity to cephaloridine
-
-
?
ceftriaxone + H2O
(2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, B2BSN6
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Q2HY42, Q9XAY4
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
P04190
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-, Q708V3, Q708V4, Q8RNV0, Q9AL74
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-, Q59517
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Q7WZ37
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Q704U4
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Q3SAW3
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-, Q6XL56
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Q20I87
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Q8GIW8
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Q4TVR4
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
A3RIY0
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
A1EGT8
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
B8R6A5, C1J897, C1J899, C1J8A0
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-, Q6D395
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
93% relative activity to cephaloridine
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
2% of the activity with amoxicillin
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Q8KSA6
beta-lactamases CTX-M-25
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Q8GD10
beta-lactamases CTX-M-26
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
GC1 beta-lactamase
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
plasmid-encoded, pBC1e, beta-lactamase ACT-1, plasmid-encoded, pBC2e, beta-lactamase MIR-1, plasmid-encoded, pBC3e, beta-lactamase CMY-1, plasmid-encoded, pBC4e, beta-lactamase CMY-2
-
-
?
cefuroxime + H2O
?
show the reaction diagram
-
poor substrate for P99 beta-lactamase
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Pseudomonas aeruginosa M5109
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Citrobacter koseri CK4
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Enterobacter cloacae P99, Enterobacter cloacae GC1
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Escherichia coli JM101
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Staphylococcus aureus PC1
-
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Yersinia ruckeri 1006/94
Q20I87
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Bacillus clausii NR
A8RR46
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Pseudomonas aeruginosa SL2
Q2HY42, Q9XAY4
-
-
-
?
cefuroxime + H2O
?
show the reaction diagram
Escherichia coli E384
A3RIY0
-
-
-
?
cefuroxime + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy[[(2E)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, B2BSN6
-
-
-
?
cefuroxime + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy[[(2E)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, Q670S6
-
-
-
?
cefuroxime + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy[[(2E)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-
-
-
-
?
cefuroxime + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy[[(2E)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
E7BCS7
-
-
-
?
cefuroxime + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy[[(2E)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q7WYA8
-
-
-
?
cefuroxime + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy[[(2E)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, Q8KQ59
-
-
-
?
cefuroxime + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy[[(2E)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q5U807
-
-
-
?
cefuroxime + H2O
(2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy[[(2E)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q8KRJ3
-
-
-
?
CENTA + H2O
?
show the reaction diagram
-
-
-
-
?
CENTA + H2O
?
show the reaction diagram
P05364
-
-
-
?
CENTA + H2O
?
show the reaction diagram
-
-
-
-
?
CENTA + H2O
?
show the reaction diagram
-, Q6XL56
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
P05364
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
P85302
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
plasmid pBG66
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
-
plasmid-encoded, pBC1e, beta-lactamase ACT-1, plasmid-encoded, pBC2e, beta-lactamase MIR-1, plasmid-encoded, pBC3e, beta-lactamase CMY-1, plasmid-encoded, pBC4e, beta-lactamase CMY-2
-
-
?
cephalexin + H2O
?
show the reaction diagram
Enterobacter aerogenes 1082E
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
Streptomyces sp. R39
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
Enterobacter cloacae P99
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
Psychrobacter immobilis A5
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa Dalgleish
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa PU21 R151
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
Morganella morganii 1510
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa GN10362
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
Citrobacter freundii GN7391
-
-
-
-
?
cephalexin + H2O
?
show the reaction diagram
Morganella morganii GN5407
-
-
-
-
?
cephalexin + H2O
(2R)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-
-
-
-
?
cephalexin + H2O
(2R)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, B2BSN6
-
-
-
?
cephaloglycin + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloglycin + H2O
?
show the reaction diagram
Streptomyces sp., Streptomyces albus, Streptomyces sp. R39
-
-
-
-
?
cephaloglycin + H2O
?
show the reaction diagram
Escherichia coli JM105
-
-
-
-
?
cephaloridin + H2O
?
show the reaction diagram
Q20I87
-
-
-
?
cephaloridin + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
P52699
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
-
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-, Q59517
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Q6VCW0, -
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-, Q6PL88
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Q76DI4
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-, Q6GVZ4
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Q3SAW3
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-, Q5I2N2
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Q5QT35
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Q09HD0
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
P00811
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
A8R403
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
beta-lactamase III
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
100% relative activity to other substrates tested
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
poor substrate, beta-lactamase I
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
3% relative activity to benzylpenicillin
-
-
?
cephaloridine + H2O
?
show the reaction diagram
-
plasmid-encoded, pBC1e, beta-lactamase ACT-1, plasmid-encoded, pBC2e, beta-lactamase MIR-1, plasmid-encoded, pBC3e, beta-lactamase CMY-1, plasmid-encoded, pBC4e, beta-lactamase CMY-2
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Enterobacter aerogenes 1082E
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Escherichia coli JM83
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Enterobacter cloacae P99
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Pseudomonas aeruginosa Dalgleish
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Serratia fonticola CUV
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Pseudomonas aeruginosa PU21 R151
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Escherichia coli HKY28
Q76DI4
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Klebsiella pneumoniae CHAK36
Q09HD0
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Bacillus cereus 569/H/9
-
beta-lactamase III
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Bacillus cereus 569/H/9
-
poor substrate, beta-lactamase I
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Morganella morganii 1510
-
-
-
-
-, ?
cephaloridine + H2O
?
show the reaction diagram
Bacillus cereus 5/B
-
poor substrate, beta-lactamase I
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Citrobacter koseri VAN
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Escherichia coli JM105
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Escherichia coli JM101
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Bacillus sp. No. 170
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Pseudomonas aeruginosa GN10362
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Citrobacter freundii GN7391
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Staphylococcus aureus PC1
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Escherichia coli PEY
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Bacillus clausii NR
A8RR46
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Morganella morganii GN5407
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Streptomyces sp. E750-3
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Pseudomonas aeruginosa PU21 RPL11
-
-
-
-
?
cephaloridine + H2O
?
show the reaction diagram
Clostridium butyricum CB269
-
-
-
-
?
cephaloridine + H2O
(2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
-
-
-
-
?
cephaloridine + H2O
(2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
show the reaction diagram
plasmid pGEM-T-easy
-
-
-
-
?
cephalosporin + H2O
?
show the reaction diagram
P00811
-
-
-
?
cephalosporin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalosporin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalosporin + H2O
?
show the reaction diagram
Q0ZA00, Q1W755
-
-
-
?
cephalosporin + H2O
?
show the reaction diagram
Q1W756, Q1W758
-
-
-
?
cephalosporin + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
cephalosporin + H2O
?
show the reaction diagram
A3RIY0
-
-
-
?
cephalosporin + H2O
?
show the reaction diagram
-
the enzyme is responsible for the resistance to extended spectrum cephalosporins
-
-
?
cephalosporin + H2O
?
show the reaction diagram
Yersinia frederiksenii C-115
Q0ZA00, Q1W755
-
-
-
?
cephalosporin + H2O
?
show the reaction diagram
Yersinia intermedia C-702
Q1W756, Q1W758
-
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
-
-
-
-
-
cephalosporin C + H2O
?
show the reaction diagram
-
-
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
-
-
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
-
-
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
-
-
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
-
-
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
-
-
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
-
-
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
-
-
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
-
poor substrate
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
-
poor substrate, beta-lactamse I
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
Escherichia coli JM83
-
-
-
-
-
cephalosporin C + H2O
?
show the reaction diagram
Enterobacter cloacae P99
-
-
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
Bacillus cereus 569/H/9
-
poor substrate, beta-lactamse I
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
Bacillus cereus 5/B
-
poor substrate, beta-lactamse I
-
-
?
cephalosporin C + H2O
?
show the reaction diagram
Escherichia coli JM105
-
-
-
-
-
cephalosporin C + H2O
?
show the reaction diagram
Bacillus licheniformis 749/C, Bacillus licheniformis 6346/C
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q2HY42, Q9XAY4
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q708V3, Q708V4, Q8RNV0, Q9AL74
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-, Q59517
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q7WZ37
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q6VCW0, -
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q704U4
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q3SAW3
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-, Q5I2N2
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-, Q6XL56
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q704Y9, Q704Z0, Q705J0
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q20I87
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q8GIW8
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-, B3FIE3
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q09HD0
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q4TVR4
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
A5LH21, -
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
P13661
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
A3RIY0
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
P13661, P62593
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
B8R6A5, C1J897, C1J899, C1J8A0
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
P00811
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-, Q6D395
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
plasmid pBG66
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
poor substrate
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
best substrate
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
1% relative activity to benzylpenicillin
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
50% relative activity to cephaloridine
-
-
?
cephalothin + H2O
?
show the reaction diagram
-, Q6GVZ4
101% of the activity with cephaloridine
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q8KSA6
beta-lactamases CTX-M-25
-
-
?
cephalothin + H2O
?
show the reaction diagram
Q8GD10
beta-lactamases CTX-M-26
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
GC1 beta-lactamase, P99 beta-lactamase
-
-
?
cephalothin + H2O
?
show the reaction diagram
-
plasmid-encoded, pBC1e, beta-lactamase ACT-1, plasmid-encoded, pBC2e, beta-lactamase MIR-1, plasmid-encoded, pBC3e, beta-lactamase CMY-1, plasmid-encoded, pBC4e, beta-lactamase CMY-2
-
-
?
cephalothin + H2O
?
show the reaction diagram
Enterobacter aerogenes 1082E
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Morganella morganii PP29
Q704Z0
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Escherichia coli DH5alpha
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa M5109
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Citrobacter koseri CK4
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Streptomyces sp. R39
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Escherichia coli JM83
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Enterobacter cloacae P99
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Enterobacter cloacae P99
-
best substrate, GC1 beta-lactamase, P99 beta-lactamase
-
-
?
cephalothin + H2O
?
show the reaction diagram
Enterobacter cloacae P99
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Shigella sonnei UIH-1
A5LH21
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Enterobacter cloacae GC1
-
best substrate, GC1 beta-lactamase, P99 beta-lactamase
-
-
?
cephalothin + H2O
?
show the reaction diagram
Kluyvera ascorbata 68
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa Dalgleish
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa Dalgleish
-
poor substrate
-
-
?
cephalothin + H2O
?
show the reaction diagram
Serratia fonticola CUV
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa PU21 R151
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Escherichia coli RB791
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Klebsiella pneumoniae CHAK36
Q09HD0
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Morganella morganii 1510
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Enterobacter cloacae NOR-1
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Citrobacter koseri VAN
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Morganella morganii PP19
Q705J0
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Morganella morganii PP37
Q704Y9
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Bacillus sp. No. 170
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa GN10362
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Achromobacter xylosoxidans CIP69598
B3FIE3
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Citrobacter freundii GN7391
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Staphylococcus aureus PC1
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Yersinia ruckeri 1006/94
Q20I87
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Escherichia coli PEY
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Bacillus clausii NR
A8RR46
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Morganella morganii GN5407
-
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Pseudomonas aeruginosa SL2
Q2HY42, Q9XAY4
-
-
-
?
cephalothin + H2O
?
show the reaction diagram
Escherichia coli E384
A3RIY0
-
-
-
?
cephalothin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-
-
-
-
?
cephalothin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q6XEC0
-
-
-
?
cephalothin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
plasmid pQE32Chl17
-
-
-
-
?
cephalothin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, B2BSN6
-
-
-
?
cephalothin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
plasmid pBC
-
-
-
-
?
cephalothin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, Q670S6
-
-
-
?
cephalothin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
plasmid pGEM-T-easy
-
-
-
-
?
cephalothin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, I6S7G0
-
-
-
?
cephalotin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalotin + H2O
?
show the reaction diagram
-
-
-
-
?
cephalotin + H2O
?
show the reaction diagram
-, P00808
-
-
-
?
cephalotin + H2O
?
show the reaction diagram
P52700
-
-
-
?
cephalotin + H2O
?
show the reaction diagram
-, Q6PL88
-
-
-
?
cephalotin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q7WYA8
-
-
-
?
cephalotin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
-, Q8KQ59
-
-
-
?
cephalotin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q5U807
-
-
-
?
cephalotin + H2O
(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
show the reaction diagram
Q8KRJ3
-
-
-
?
cephamandol + H2O
?
show the reaction diagram
-
-
-
-
?
cephapirin + H2O
?
show the reaction diagram
Staphylococcus aureus, Staphylococcus aureus PC1
-
-
-
-
?
cephradine + H2O
?
show the reaction diagram
-
-
-
-
?
cephradine + H2O
?
show the reaction diagram
-
-
-
-
?
cephradine + H2O
?
show the reaction diagram
-
-
-
-
-
ciclacillin + H2O
?
show the reaction diagram
-
-
-
-
?
clavulanic acid + H2O
?
show the reaction diagram
-
-
-
-
?
clavulanic acid + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
P05364
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
P85302
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
Q6VCW0, -
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
Q5QT35
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
poor substrate
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
specific for
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
38% relative activity to benzylpenicillin
-
-
?
cloxacillin + H2O
?
show the reaction diagram
-
low hydrolysis rate
-
-
?
cloxacillin + H2O
?
show the reaction diagram
Bacillus cereus, Bacillus cereus 569/H/9
-
hydrolysis or inhibition, depending on pH, temperature, ratio enzyme/cloaxcillin
-
-
-
cloxacillin + H2O
?
show the reaction diagram
Escherichia coli JM105
-
-
-
-
?
cloxacillin + H2O
?
show the reaction diagram
Bacillus sp. No. 170
-
-
-
-
?
cloxacillin + H2O
(2R,4S)-2-[(R)-carboxy([[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl]amino)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
show the reaction diagram
plasmid pGEM-T-easy
-
-
-
-
?
CP 45899 + H2O
?
show the reaction diagram
-
-
-
-
?
doripenem + H2O
?
show the reaction diagram
-
-
-
-
?
ephalothin + H2O
?
show the reaction diagram
-
-
-
-
?
ertapenem + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
ertapenem + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
ertapenem + H2O
(4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-([(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl)-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q6XEC0
-
-
-
?
ertapenem + H2O
(4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-([(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl)-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
E7BCS7
-
-
-
?
ertapenem + H2O
(4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-([(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl)-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q7WYA8
-
-
-
?
ertapenem + H2O
(4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-([(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl)-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q5U807
-
-
-
?
faropenem + H2O
?
show the reaction diagram
-, Q6D395
-
-
-
?
faropenem + H2O
(2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-tetrahydrofuran-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid
show the reaction diagram
Q6XEC0
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q2HY42, Q9XAY4
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-, Q7BHJ5
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
P52699
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
P26918
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-, Q708V3, Q708V4, Q8RNV0, Q9AL74
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
P52700
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-, Q59517
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q6VCW0, -
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-, Q6PL88
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q704U4
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-, Q5I2N2
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q4ZE97
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q704Y9, Q704Z0, Q705J0
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q5QT35
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q8GIW8
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q6JE29
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-, B3FIE3
-
-
-
?
imipenem + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q09HD0
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q7DH52
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
imipenem + H2O
?
show the reaction diagram
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
O31272
-
-
-
?
imipenem + H2O
?
show the reaction diagram
B8R6A5, C1J897, C1J899, C1J8A0
-
-
-
?
imipenem + H2O
?
show the reaction diagram
P00811
-
-
-
?
imipenem + H2O
?
show the reaction diagram
A8R403
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
5% of the activity with amoxicillin
-
-
?
imipenem + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
as active as amoxicillin
-
-
?
imipenem + H2O
?
show the reaction diagram
-
plasmid-encoded, pBC1e, beta-lactamase ACT-1, plasmid-encoded, pBC2e, beta-lactamase MIR-1, plasmid-encoded, pBC3e, beta-lactamase CMY-1, plasmid-encoded, pBC4e, beta-lactamase CMY-2
-
-
?
imipenem + H2O
?
show the reaction diagram
-
moderate rate of hydrolysis
-
-
?
imipenem + H2O
?
show the reaction diagram
-
activity in resistant strains
-
-
?
imipenem + H2O
?
show the reaction diagram
-, Q7BHJ5
the enzyme shows carbapenemase activity, e.g. against the carbapenem antibiotics meropenem and imipenem used in treatment of Pseudomonas aeruginosa infection, and contributes to resistance to anti-pseudomonal agents, overview
-
-
?
imipenem + H2O
?
show the reaction diagram
Q7DH52
high activity of IMP-10
-
-
?
imipenem + H2O
?
show the reaction diagram
Enterobacter cloacae P99
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Klebsiella pneumoniae 2873
-
moderate rate of hydrolysis
-
-
?
imipenem + H2O
?
show the reaction diagram
Aeromonas sobria 163a
-
-
-
-
?
imipenem + H2O
?
show the reaction diagram
Achromobacter xylosoxidans CIP69598
B3FIE3
-
-
-
?
imipenem + H2O
(5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q6XEC0
-
-
-
?
imipenem + H2O
(5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
plasmid pBC
-
-
-
-
?
imipenem + H2O
(5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
E7BCS7
-
-
-
?
imipenem + H2O
(5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q7WYA8
-
-
-
?
imipenem + H2O
(5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q5U807
-
-
-
?
imipenem + H2O
(5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q9RMI1, -
-
-
-
?
imipenem + H2O
(5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q8KRJ3
-
-
-
?
imipenem + H2O
(5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
-, I6S7G0
-
-
-
?
imipenem + H2O
(5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q9RMI1
-
-
-
?
loracarbef + H2O
?
show the reaction diagram
-
-
-
-
?
mecillinam + H2O
?
show the reaction diagram
-
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-
-
-
-
?
meropenem + H2O
?
show the reaction diagram
Q2HY42, Q9XAY4
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-, Q7BHJ5
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-
-
-
-
?
meropenem + H2O
?
show the reaction diagram
P52700
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-
-
-
-
?
meropenem + H2O
?
show the reaction diagram
Q6VCW0, -
-
-
-
?
meropenem + H2O
?
show the reaction diagram
Q704U4
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-, Q5I2N2
-
-
-
?
meropenem + H2O
?
show the reaction diagram
Q4ZE97
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-
-
-
-
?
meropenem + H2O
?
show the reaction diagram
Q8GIW8
-
-
-
?
meropenem + H2O
?
show the reaction diagram
Q6JE29
-
-
-
?
meropenem + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
meropenem + H2O
?
show the reaction diagram
Q8GCU7
-
-
-
?
meropenem + H2O
?
show the reaction diagram
B8R6A5, C1J897, C1J899, C1J8A0
-
-
-
?
meropenem + H2O
?
show the reaction diagram
A8R403
-
-
-
?
meropenem + H2O
?
show the reaction diagram
-, Q6D395
-
-
-
?
meropenem + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
230% of the activity with amoxicillin
-
-
?
meropenem + H2O
?
show the reaction diagram
-
activity in resistant strains
-
-
?
meropenem + H2O
?
show the reaction diagram
-, Q7BHJ5
the enzyme shows carbapenemase activity, e.g. against the carbapenem antibiotics meropenem and imipenem used in treatment of Pseudomonas aeruginosa infection, and contributes to resistance to anti-pseudomonal agents, overview
-
-
?
meropenem + H2O
?
show the reaction diagram
Aeromonas sobria 163a
-
-
-
-
?
meropenem + H2O
(4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q6XEC0
-
-
-
?
meropenem + H2O
(4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
E7BCS7
-
-
-
-
meropenem + H2O
(4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q7WYA8
-
-
-
-
meropenem + H2O
(4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q5U807
-
-
-
-
meropenem + H2O
(4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q9RMI1, -
-
-
-
-
meropenem + H2O
(4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
Q8KRJ3
-
-
-
-
meropenem + H2O
(4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-[[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
show the reaction diagram
-, I6S7G0
-
-
-
-
methicillin + H2O
?
show the reaction diagram
-
-
-
-
?
methicillin + H2O
?
show the reaction diagram
-
-
-
-
?
methicillin + H2O
?
show the reaction diagram
-
-
-
-
ir
methicillin + H2O
?
show the reaction diagram
-
-
-
-
?
methicillin + H2O
?
show the reaction diagram
-
-
-
-
?
methicillin + H2O
?
show the reaction diagram
-
-
-
-
?
methicillin + H2O
?
show the reaction diagram
-
-
-
-
ir
methicillin + H2O
?
show the reaction diagram
-
-
-
-
?
methicillin + H2O
?
show the reaction diagram
-
-
-
-
?
methicillin + H2O
?
show the reaction diagram
-
poor substrate
-
-
?
methicillin + H2O
?
show the reaction diagram
-
beta-lactamase III
-
-
?
methicillin + H2O
?
show the reaction diagram
-
beta-lactamase III
-
-
?
methicillin + H2O
?
show the reaction diagram
-
low hydrolysis rate
-
-
?
methicillin + H2O
?
show the reaction diagram
-
73% relative activity
-
-
?
methicillin + H2O
?
show the reaction diagram
Bacillus cereus 569/H/9
-
beta-lactamase III
-
-
?
methicillin + H2O
?
show the reaction diagram
Bacillus cereus 569/H/9
-
-
-
-
?
methicillin + H2O
?
show the reaction diagram
Bacillus cereus 5/B
-
-
-
-
?
methicillin + H2O
?
show the reaction diagram
Bacillus licheniformis 749/C, Bacillus licheniformis 6346/C
-
-
-
-
?
methicillin + H2O
?
show the reaction diagram
Clostridium butyricum CB269
-
beta-lactamase III
-
-
?
mezlocillin + H2O
?
show the reaction diagram
-, Q59517
-
-
-
?
moxalactam + H2O
?
show the reaction diagram
-
-
-
-
?
moxalactam + H2O
?
show the reaction diagram
-
-
-
-
?
moxalactam + H2O
?
show the reaction diagram
-, P00808
-
-
-
?
moxalactam + H2O
?
show the reaction diagram
-
-
-
-
?
moxalactam + H2O
?
show the reaction diagram
-
-
-
-
?
moxalactam + H2O
?
show the reaction diagram
Q704U4
-
-
-
?
moxalactam + H2O
?
show the reaction diagram
A8RR46, -
-
-
-
?
moxalactam + H2O
?
show the reaction diagram
Q840P9
-
-
-
?
moxalactam + H2O
?
show the reaction diagram
A8R403
-
-
-
?
moxalactam + H2O
?
show the reaction diagram
Q9RMI1, -
-
-
-
?
moxalactam + H2O
?
show the reaction diagram
Q53BU0, Q53BU1, -
230% of the activity with amoxicillin
-
-
?
moxalactam + H2O
?
show the reaction diagram
Q9RMI1
-
-
-
?
N-(phenylacetyl)thioglycylglycolic acid + H2O
phenylacetylglycine + glycolate
show the reaction diagram
Enterobacter cloacae, Enterobacter cloacae P99
-
-
-
-
?
nitrocefin + H2O
?
show the reaction diagram
-
-
-
-
?
nitrocefin + H2O
?
show the reaction diagram
-
-