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Literature summary for 3.5.2.6 extracted from

  • Mohamed, M.S.; Hussein, W.M.; McGeary, R.P.; Vella, P.; Schenk, G.; Abd El-Hameed, R.H.
    Synthesis and kinetic testing of new inhibitors for a metallo-beta-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa (2011), Eur. J. Med. Chem., 46, 6075-6082.
    View publication on PubMed
Search for more literature for 3.5.2.6

Cloned(Commentary)

Cloned (Comment) Organism
-
 Klebsiella pneumoniae

Inhibitors

Inhibitors Comment Organism Structure
2-(7-(4-methoxyphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylidene)-malononitrile
-
 Klebsiella pneumoniae
4-chloro-7-(4-methoxyphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine
-
 Klebsiella pneumoniae
4-chloro-7-(4-methylphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine
-
 Klebsiella pneumoniae
4-chloro-7-(4-methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
-
 Klebsiella pneumoniae
7-(4-methylphenyl)-8,9-diphenyl-7H-pyrrolo[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine-3-thione
-
 Klebsiella pneumoniae
N-benzylidene-N'-(7-(4-methylphenyl)-5,6-diphenyl-7Hpyrrolo[2,3-d]pyramidin-4-yl)-hydrazine
-
 Klebsiella pneumoniae

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae
-
-
-

Synonyms

Synonyms Comment Organism
IMP-1
-
 Klebsiella pneumoniae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.012
-
 4-chloro-7-(4-methoxyphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine pH 7.0, temperature not specified in the publication Klebsiella pneumoniae
0.015
-
 7-(4-methylphenyl)-8,9-diphenyl-7H-pyrrolo[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine-3-thione pH 7.0, temperature not specified in the publication Klebsiella pneumoniae
0.018
-
 N-benzylidene-N'-(7-(4-methylphenyl)-5,6-diphenyl-7Hpyrrolo[2,3-d]pyramidin-4-yl)-hydrazine pH 7.0, temperature not specified in the publication Klebsiella pneumoniae
0.019
-
 4-chloro-7-(4-methylphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine pH 7.0, temperature not specified in the publication Klebsiella pneumoniae
0.029
-
 2-(7-(4-methoxyphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylidene)-malononitrile pH 7.0, temperature not specified in the publication Klebsiella pneumoniae
0.033
-
 4-chloro-7-(4-methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine pH 7.0, temperature not specified in the publication Klebsiella pneumoniae