Literature summary for 3.5.2.6 extracted from

Bonnefoy, A.; Dupuis-Hamelin, C.; Steier, V.; Delachaume, C.; Seys, C.; Stachyra, T.; Fairley, M.; Guitton, M.; Lampilas, M.
In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor (2004), J. Antimicrob. Chemother., 54, 410-417.

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Inhibitors

Inhibitors	Comment	Organism	Structure
AVE1330A	IC50: 80 nM	Enterobacter cloacae
AVE1330A	IC50: 8 nM	Escherichia coli
clavulanic acid	IC50: 1 mM	Enterobacter cloacae
clavulanic acid	IC50: 130 nM	Escherichia coli
tazobactam	IC50: 5000 nM	Enterobacter cloacae
tazobactam	IC50: 40 nM	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Enterobacter cloacae	-	-	-
Enterobacter cloacae 293HT6	-	-	-
Escherichia coli	-	-	-

Synonyms

Synonyms	Comment	Organism
P99 beta-lactamase	-	Enterobacter cloacae
TEM-1 beta-lactamase	-	Escherichia coli

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000008	-	IC50: 8 nM	Escherichia coli	AVE1330A
0.00004	-	IC50: 40 nM	Escherichia coli	tazobactam
0.00008	-	IC50: 80 nM	Enterobacter cloacae	AVE1330A
0.00013	-	IC50: 130 nM	Escherichia coli	clavulanic acid
0.005	-	IC50: 5000 nM	Enterobacter cloacae	tazobactam
1	-	IC50: 1 mM	Enterobacter cloacae	clavulanic acid

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Release 2023.1 (January 2023)