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Literature summary for 3.5.2.6 extracted from

  • Zygmunt, D.J.; Stratton, C.W.; Kernodle, D.S.
    Characterization of four beta-lactamases produced by Straphylococcus aureus (1992), Antimicrob. Agents Chemother., 36, 440-445.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0032
-
cefamandole beta-lactamase D Staphylococcus aureus
0.0047
-
cephalothin beta-lactamase D Staphylococcus aureus
0.005
-
cefamandole beta-lactamase A Staphylococcus aureus
0.0052
-
cephapirin beta-lactamase A Staphylococcus aureus
0.0052
-
cephalothin beta-lactamase C Staphylococcus aureus
0.0059
-
nitrocefin beta-lactamase D Staphylococcus aureus
0.006
-
cefamandole beta-lactamase B Staphylococcus aureus
0.0062
-
cephalothin beta-lactamase B Staphylococcus aureus
0.0064
-
nitrocefin beta-lactamase A Staphylococcus aureus
0.0065
-
cefamandole beta-lactamase C Staphylococcus aureus
0.0068
-
cephalothin beta-lactamase A Staphylococcus aureus
0.0079
-
cephaloridine beta-lactamase D Staphylococcus aureus
0.011
-
cephaloridine beta-lactamase A Staphylococcus aureus
0.0115
-
cephaloridine beta-lactamase C Staphylococcus aureus
0.0122
-
cephapirin beta-lactamase D Staphylococcus aureus
0.0157
-
nitrocefin beta-lactamase B Staphylococcus aureus
0.018
-
cefazolin beta-lactamase A Staphylococcus aureus
0.0194
-
cephaloridine beta-lactamase B Staphylococcus aureus
0.0204
-
nitrocefin beta-lactamase C Staphylococcus aureus
0.0386
-
penicillin G beta-lactamase B Staphylococcus aureus
0.0472
-
cephapirin beta-lactamase C Staphylococcus aureus
0.0499
-
cefazolin beta-lactamase D Staphylococcus aureus
0.0511
-
penicillin G beta-lactamase A Staphylococcus aureus
0.0559
-
penicillin G beta-lactamase C Staphylococcus aureus
0.0795
-
cephapirin beta-lactamase B Staphylococcus aureus
0.1126
-
penicillin G beta-lactamase D Staphylococcus aureus
0.122
-
ampicillin beta-lactamase C Staphylococcus aureus
0.129
-
ampicillin beta-lactamase D Staphylococcus aureus
0.16
-
ampicillin beta-lactamase B Staphylococcus aureus
0.254
-
cefazolin beta-lactamase B Staphylococcus aureus
0.255
-
ampicillin beta-lactamase A Staphylococcus aureus
0.267
-
cefazolin beta-lactamase C Staphylococcus aureus
0.378
-
cefuroxime beta-lactamase A Staphylococcus aureus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Staphylococcus aureus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
SDS-PAGE Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus
-
strains PC11, 22260, V137, FAR8, FAR10
-
Staphylococcus aureus PC1
-
-
-

Purification (Commentary)

Purification (Comment) Organism
4 enzymes: beta-lactamase A-D Staphylococcus aureus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
80
-
substrate penicillin G, beta-lactamase D Staphylococcus aureus
243
-
substrate penicillin G, beta-lactamase A Staphylococcus aureus
252
-
substrate penicillin G, beta-lactamase B Staphylococcus aureus
364
-
substrate penicillin G, beta-lactamase C Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O
-
Staphylococcus aureus (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
ampicillin + H2O
-
Staphylococcus aureus PC1 (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
cefamandole + H2O
-
Staphylococcus aureus (2R)-2-[(R)-carboxy{[(2R)-2-hydroxy-2-phenylacetyl]amino}methyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefazolin + H2O
-
Staphylococcus aureus (2R)-2-[(R)-carboxy[(1H-tetrazol-1-ylacetyl)amino]methyl]-5-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefuroxime + H2O
-
Staphylococcus aureus (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefuroxime + H2O
-
Staphylococcus aureus PC1 (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephaloridine + H2O
-
Staphylococcus aureus (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephaloridine + H2O
-
Staphylococcus aureus PC1 (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephalothin + H2O
-
Staphylococcus aureus (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephalothin + H2O
-
Staphylococcus aureus PC1 (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephapirin + H2O
-
Staphylococcus aureus (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy{2-[(pyridin-4-yl)sulfanyl]acetamido}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephapirin + H2O
-
Staphylococcus aureus PC1 (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy{2-[(pyridin-4-yl)sulfanyl]acetamido}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
nitrocefin + H2O
-
Staphylococcus aureus (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
penicillin G + H2O
-
Staphylococcus aureus (2R,4S)-2-[(R)-carboxy[(phenylacetyl)amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00667
-
cephalothin beta-lactamase D Staphylococcus aureus
0.00833
-
cefuroxime beta-lactamase A Staphylococcus aureus
0.0167
-
cephalothin beta-lactamase A Staphylococcus aureus
0.05
-
cefamandole beta-lactamase A Staphylococcus aureus
0.05
-
cefamandole beta-lactamase D Staphylococcus aureus
0.1
-
cephalothin beta-lactamase B Staphylococcus aureus
0.1
-
cephalothin beta-lactamase C Staphylococcus aureus
0.25
-
cephapirin beta-lactamase D Staphylococcus aureus
0.3
-
cefamandole beta-lactamase C Staphylococcus aureus
0.35
-
cefamandole beta-lactamase B Staphylococcus aureus
0.367
-
cephapirin beta-lactamase A Staphylococcus aureus
1
-
cefazolin beta-lactamase A Staphylococcus aureus
1.18
-
cephapirin beta-lactamase C Staphylococcus aureus
1.25
-
cephaloridine beta-lactamase D Staphylococcus aureus
1.82
-
cephapirin beta-lactamase B Staphylococcus aureus
1.92
-
cefazolin beta-lactamase D Staphylococcus aureus
1.95
-
cephaloridine beta-lactamase A Staphylococcus aureus
3.95
-
cefazolin beta-lactamase C Staphylococcus aureus
4.67
-
cefazolin beta-lactamase B Staphylococcus aureus
5.6
-
cephaloridine beta-lactamase C Staphylococcus aureus
6.65
-
cephaloridine beta-lactamase B Staphylococcus aureus
13.7
-
nitrocefin beta-lactamase C Staphylococcus aureus
16.5
-
nitrocefin beta-lactamase B Staphylococcus aureus
23.2
-
nitrocefin beta-lactamase A Staphylococcus aureus
25.6
-
nitrocefin beta-lactamase D Staphylococcus aureus
46
-
penicillin G beta-lactamase D Staphylococcus aureus
133
-
ampicillin beta-lactamase D Staphylococcus aureus
156
-
penicillin G beta-lactamase B Staphylococcus aureus
171
-
penicillin G beta-lactamase A Staphylococcus aureus
210
-
penicillin G beta-lactamase C Staphylococcus aureus
308
-
ampicillin beta-lactamase A Staphylococcus aureus
355
-
ampicillin beta-lactamase C Staphylococcus aureus
412
-
ampicillin beta-lactamase B Staphylococcus aureus