Information on EC 2.3.1.48 - histone acetyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
2.3.1.48
-
RECOMMENDED NAME
GeneOntology No.
histone acetyltransferase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Acyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:histone acetyltransferase
A group of enzymes with differing specificities towards histone acceptors.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
acetyltransferase, histone
-
-
-
-
Ada2/Ada3/Gcn5 complex
-
-
arginine methyltransferase A
-
-
arginine methyltransferase B
-
-
At3g14980
F4IXE7
-
ATAC2
Q9H8E8
-
ATAC2
-
-
ATase1
-
-
ATase2
-
-
Cbp
-
-
CBP histone acetyltransferase
-
-
CREB binding protein
-
-
CREB-binding protein
-
-
east1
Q93ZR1
-
ELONGATA3
Q93ZR1
component of the elongator complex
elongator protein 3
Q9VQZ6
catalytic subunit of the elongator complex
enhancer-of-asymmetric leaves-two1
Q93ZR1
-
Esa1
-
component of the NuA4 histone acetyltransferase complex
factor acetyltransferase
-
enzyme form A is also able to acetylate nonhistone proteins, mostly transcription factors, overview
factor acetyltransferase
Homo sapiens GCN5
-
enzyme form A is also able to acetylate nonhistone proteins, mostly transcription factors, overview
-
factor acetyltransferase
-
enzyme form A is also able to acetylate nonhistone proteins, mostly transcription factors, overview
FAT
-
when acetylating nonhistone transcription factor proteins, factor specific, overview
FAT
Homo sapiens GCN5
-
when acetylating nonhistone transcription factor proteins, factor specific, overview
-
FAT
-
when acetylating nonhistone transcription factor proteins, factor specific, overview
Gcn5
Q92830
-
Gcn5
Q9H8E8
-
Gcn5
-
-
Gcn5
Tetrahymena sp. GCN5
-
-
-
Gcn5/PCAF histone acetyltransferase
-
-
general control non-derepressible 5
-
-
general control non-repressed protein5
-
-
GNAT-related histone acetyltransferase complex
-
PCAF, STAGA or TFTC
GNAT-related histone acetyltransferase complex
-
SAGA, ADA or HAT-A2
H4 lysine acetyltransferase
-
-
HAG3
Q93ZR1
gene name
HAT
Danio rerio zMoz
-
-
-
HAT
Q8WYB5
-
HAT
Q9H8E8
-
HAT
Homo sapiens GCN5
-
-
-
HAT
-
-
HAT
Tetrahymena sp. GCN5
-
-
-
HAT
Tetrahymena thermophila GCN5
-
;
-
HAT
-
-
HAT-B complex
-
-
Hat1
O14929
-
histone (H4 K16) acetyltransferase
-
-
histone (H4 K16) acetyltransferase
Q9H7Z6
-
histone acetokinase
-
-
-
-
histone acetyl transferase
-
-
histone acetyl transferase
-
-
histone acetylase
-
-
-
-
histone acetylase
-
-
histone acetyltransferase
-
-
histone acetyltransferase
Herpes simplex virus
-
-
histone acetyltransferase
-
-
histone acetyltransferase
-
-
histone acetyltransferase
-
-
histone acetyltransferase
-
-
histone acetyltransferase
-
-
histone acetyltransferase
Q08649
-
histone acetyltransferase AtGCN5
-
-
histone acetyltransferase B
-
-
histone acetyltransferase Tip60
-
-
histone acetyltransferase-1
-
-
histone H3 acetyltransferase
-
-
histone H4 acetyltransferase
-
-
histone transacetylase
-
-
-
-
histone/protein lysine acetyltransferase
-
-
human acetylase binding to ORC1
-
-
Kat2A
Q92830
-
lysine acetyltransferase
-
-
lysine acetyltransferase
-
-
lysine acetyltransferase
-
-
lysine acetyltransferase p300
-
-
Mof
Q9H7Z6
-
monocytic leukemia zinc finger
-
-
Morf
-
-
MORF histone acetyltransferases
-
-
MOZ histone acetyltransferases
-
-
Moz related factor
-
-
MYST protein lysine acetyltransferases
-
-
MYST protein lysine acetyltransferases
Q08649
-
MYST-related histone acetyltransferase complex
-
Tip60
MYST-related histone acetyltransferase complex
-
NuA4, NuA3 or ASA(SAS-I)
MYST1
-
-
MYST1
Q9H7Z6
-
NCOAT
-
-
NCOAT
-
nuclear cytoplasmic O-GlcNacase and acetyltransferase, bifunctional enzyme
NuA4 histone acetyltransferase
P53930
-
nuclear cytoplasmicO-GlcNAcase and acetyltransferase
-
-
nucleosome-histone acetyltransferase
-
-
-
-
P/CAF histone acetyltransferase
-
-
p300 histone acetyltransferase
-
-
p300/CBP
Herpes simplex virus
-
-
p300/CBP
-
CREB-binding protein (KAT3A) is a homologue to p300 (KAT3B)
p300/CBP
-
CREB-binding protein (KAT3A) is a homologue of p300 (KAT3B)
p300/CBP associated factor
-
-
p300/CBP associated factor
Q09472
-
p300/CBP histone acetyltransferase
-
-
P300/CBP-associated factor
-
-
p300/CBP-associated factor (pCAF)
-
representing residues 492-658
p300HAT
-
-
PCAF
Q09472
-
PCAF
-
-
PCAF histone acetyltransferases
-
-
PF11_0192
Q8III2
gene name
PfGCN5
Q6RGS5
-
PfGCN5 HAT
-
-
Piccolo NuA4 complex
-
-
Rtt109
-
fungal-specific histone acetyltransferase
Rtt109
Saccharomyces cerevisiae BY4705
-
-
-
TAF1
-
-
Tat interacting protein of 60 kDa
-
-
Tat-interactive protein, 60 kDa
-
-
TgMYST-B
-
-
Tip60
-
-
type B histone acetyltransferase
-
-
type B histone acetyltransferase
-
-
zMoz
-
-
zMoz
Danio rerio zMoz
-
-
-
monocytic leukemia zinc finger protein
-
-
additional information
-
GCN5 belongs to the HAT family of enzymes
additional information
-
the enzyme belongs to the MYST family histone acetyltransferases which is divided in three sub-families, overview
additional information
-
type A enzymes are localized in the nuclei and acetylate nucleosomal histones as well as nonhistone proteins, type B enzymes can be found in the cytoplasmic fraction and are responsible for acetylation of newly synthesized histones before their translocation into the nucleus for chromatin assembly during DNA replication; type A enzymes can be grouped into different families based on amino acid sequence comparison and binding motifs, overview
additional information
Q9FLF7, Q9LXD7
the enzyme belongs to the MYST histone acetyltransferase family
additional information
-
the enzyme belongs to the MYST family histone acetyltransferases which is divided in three sub-families, overview
additional information
Danio rerio zMoz
-
the enzyme belongs to the MYST family histone acetyltransferases which is divided in three sub-families, overview
-
additional information
-
the enzyme belongs to the MYST family histone acetyltransferases which is divided in three sub-families, overview
additional information
-
type A enzymes are localized in the nuclei and acetylate nucleosomal histones as well as nonhistone proteins, type B enzymes can be found in the cytoplasmic fraction and are responsible for acetylation of newly synthesized histones before their translocation into the nucleus for chromatin assembly during DNA replication; type A enzymes can be grouped into different families based on amino acid sequence comparison and binding motifs, overview
additional information
-
enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family
additional information
-
HBO1 is a MYST family histone acetylase
additional information
-
MOF is a member of the MYST, i.e. Moz-Ybf2/Sas3-Sas2-Tip60, family of histone acetyltransferases, HATs
additional information
-
the enzyme belongs to the MYST family histone acetyltransferases which is divided in three sub-families, overview
additional information
-
type A enzymes are localized in the nuclei and acetylate nucleosomal histones as well as nonhistone proteins, type B enzymes can be found in the cytoplasmic fraction and are responsible for acetylation of newly synthesized histones before their translocation into the nucleus for chromatin assembly during DNA replication; type A enzymes can be grouped into different families based on amino acid sequence comparison and binding motifs, overview
additional information
Q8WYB5
enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family
additional information
Q9H8E8
part of the double-histone-acetyltransferase complex ATAC, ADA2A-containing complex
additional information
Homo sapiens GCN5
-
enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family; type A enzymes are localized in the nuclei and acetylate nucleosomal histones as well as nonhistone proteins, type B enzymes can be found in the cytoplasmic fraction and are responsible for acetylation of newly synthesized histones before their translocation into the nucleus for chromatin assembly during DNA replication; type A enzymes can be grouped into different families based on amino acid sequence comparison and binding motifs, overview
-
additional information
-
MOZ is the founding member of the MOZ, Ybf2/Sas2, Tip60 , i.e. MYST family of HATs, characterized by the presence of a conserved MYST domain that comprises both the C2HC nucleosome-binding domain and the putative HAT domain
additional information
-
MOZ, i.e. monocytic leukemia zinc finger protein, is a Myst, i.e. MOZ, Ybf2 (Sas3), Sas2, Tip60, type histone acetyltransferase, HAT
additional information
-
part of the double-histone-acetyltransferase complex ATAC, ADA2A-containing complex
additional information
-
the enzyme belongs to the MYST family histone acetyltransferases which is divided in three sub-families, overview
additional information
-
the enzyme belongs to the MYST family of histone acetyltransferases
additional information
-
enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family
additional information
-
Esa1 and MOZ belong to the MYST family of histone acetyltransferases
additional information
-
Hat1, together with Hat2 and Hif1, forms the histone acetyltransferase B, HAT-B, complex
additional information
-
the enzyme belongs to the MYST acetyltransferase family
additional information
-
the enzyme belongs to the MYST family histone acetyltransferase
additional information
-
the enzyme belongs to the MYST family histone acetyltransferases which is divided in three sub-families, overview
additional information
-
type A enzymes are localized in the nuclei and acetylate nucleosomal histones as well as nonhistone proteins, type B enzymes can be found in the cytoplasmic fraction and are responsible for acetylation of newly synthesized histones before their translocation into the nucleus for chromatin assembly during DNA replication; type A enzymes can be grouped into different families based on amino acid sequence comparison and binding motifs, overview
additional information
-
Mst1 is a member of the MYST family of histone acetyltransferases and is the likely orthologue of Saccharomyces cerevisiae Esa1 and human Tip60, i.e. KAT5
additional information
-
enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family
additional information
-
type A enzymes are localized in the nuclei and acetylate nucleosomal histones as well as nonhistone proteins, type B enzymes can be found in the cytoplasmic fraction and are responsible for acetylation of newly synthesized histones before their translocation into the nucleus for chromatin assembly during DNA replication; type A enzymes can be grouped into different families based on amino acid sequence comparison and binding motifs, overview
CAS REGISTRY NUMBER
COMMENTARY
9054-51-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Columbia-0 ecotype
-
-
Manually annotated by BRENDA team
ecotype Wassilewskija, genes gcn5-1 and gcn5-2
-
-
Manually annotated by BRENDA team
genes ham1 and ham2
-
-
Manually annotated by BRENDA team
HAM1; HAM1 or HAG4
UniProt
Manually annotated by BRENDA team
HAM2; HAM2 or HAG5
UniProt
Manually annotated by BRENDA team
Artemia nauplii
3 enzyme forms: I, II and III
-
-
Manually annotated by BRENDA team
2 enzyme forms: A and B; calf
-
-
Manually annotated by BRENDA team
3 enzyme forms: A, B, C; calf
-
-
Manually annotated by BRENDA team
enzyme forms A, B and DB
-
-
Manually annotated by BRENDA team
clinical isolate SC5314, ORF19.7491
-
-
Manually annotated by BRENDA team
zMoz
-
-
Manually annotated by BRENDA team
Danio rerio zMoz
zMoz
-
-
Manually annotated by BRENDA team
HBO1, Mof, Enok, and chameau
-
-
Manually annotated by BRENDA team
Herpes simplex virus
-
-
-
Manually annotated by BRENDA team
ATAC2
UniProt
Manually annotated by BRENDA team
catalytic subunit of the male-specific lethal hiostone acetyltransferase complex
UniProt
Manually annotated by BRENDA team
fragment EST clone of MORF protein, i.e. monocytic leukemia zinc finger protein-related factor
SwissProt
Manually annotated by BRENDA team
GCN5
-
-
Manually annotated by BRENDA team
GCN5; PCAF protein
-
-
Manually annotated by BRENDA team
GCN5; recombinant enzyme hPCAF, i.e. human p300/CBP associated factor
-
-
Manually annotated by BRENDA team
gene Hbo1
-
-
Manually annotated by BRENDA team
gene taf1
-
-
Manually annotated by BRENDA team
MORF protein, i.e. monocytic leukemia zinc finger protein-related factor
-
-
Manually annotated by BRENDA team
PCAF protein
-
-
Manually annotated by BRENDA team
Tip60, p/CAF, and p300
-
-
Manually annotated by BRENDA team
Homo sapiens GCN5
GCN5
-
-
Manually annotated by BRENDA team
i.e. HIV; recombinant from COS cell line and from Escherichia coli
-
-
Manually annotated by BRENDA team
C57BL/6 mice
-
-
Manually annotated by BRENDA team
gene cbp
-
-
Manually annotated by BRENDA team
gene Gcn5
-
-
Manually annotated by BRENDA team
MNof, Tip60, Qkf, Moz, and Morf
-
-
Manually annotated by BRENDA team
PCAF and CBP
-
-
Manually annotated by BRENDA team
Swiss albino mice, 2 months old
-
-
Manually annotated by BRENDA team
3 enzyme forms: A1, A2, B
-
-
Manually annotated by BRENDA team
2 enzyme forms: A and B
-
-
Manually annotated by BRENDA team
cv. Lincoln; enzyme form B
-
-
Manually annotated by BRENDA team
enzyme form B
-
-
Manually annotated by BRENDA team
gene PF11_0192, putative
UniProt
Manually annotated by BRENDA team
2 enzyme forms NI and NII from nucleus and 2 enzyme forms CI and CII from cytoplasm
-
-
Manually annotated by BRENDA team
2 enzyme forms: A and B
-
-
Manually annotated by BRENDA team
3 enzyme forms: A, B1, B2
-
-
Manually annotated by BRENDA team
male sprague-dawley rats
-
-
Manually annotated by BRENDA team
diverse strains
-
-
Manually annotated by BRENDA team
enzyme form A and B
-
-
Manually annotated by BRENDA team
genes/proteins Sas2, Sas4, Sas5 forming the SAS complex
-
-
Manually annotated by BRENDA team
nucleosomal H2A/H4 acetyltransferase, i.e. NuA4 protein
-
-
Manually annotated by BRENDA team
p300, Gcn5, Rtt109, and Esa1
-
-
Manually annotated by BRENDA team
several strains
-
-
Manually annotated by BRENDA team
several strains, overview, gene HAT1
-
-
Manually annotated by BRENDA team
strain BY4705
-
-
Manually annotated by BRENDA team
wild-type strain BY4741 and deletion derivatives
-
-
Manually annotated by BRENDA team
wild-type strain W303-1a, gene hat1
-
-
Manually annotated by BRENDA team
yeast piccolo NuA4 complex
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae BY4705
strain BY4705
-
-
Manually annotated by BRENDA team
diverse strains, overview
-
-
Manually annotated by BRENDA team
several strains, overview, gene HAT1
Uniprot
Manually annotated by BRENDA team
from infected african green monkey kidney cell line CV-1; i.e. SV40
-
-
Manually annotated by BRENDA team
enzyme form type I and type II
-
-
Manually annotated by BRENDA team
protein p55
-
-
Manually annotated by BRENDA team
recombinant enzyme
-
-
Manually annotated by BRENDA team
Tetrahymena sp. GCN5
GCN5
-
-
Manually annotated by BRENDA team
transcription-associated enzyme form A, containing protein p55 as catalytic subunit; yeast-NuA4-like enzyme form
-
-
Manually annotated by BRENDA team
Tetrahymena thermophila GCN5
GCN5
-
-
Manually annotated by BRENDA team
enzyme form B
Uniprot
Manually annotated by BRENDA team
enzyme form B; strain Cuzco
-
-
Manually annotated by BRENDA team
Zea mays Cuzco
strain Cuzco
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
ORGANIC SOLVENT
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
dimethyl sulfoxide
-
irreversible inactivation at 2% v/v
dimethyl sulfoxide
Zea mays Cuzco
-
irreversible inactivation at 2% v/v
-
Ethanol
-
irreversible inactivation at 2% v/v
Ethanol
Zea mays Cuzco
-
irreversible inactivation at 2% v/v
-
isopropanol
-
irreversible inactivation at 2% v/v
isopropanol
Zea mays Cuzco
-
irreversible inactivation at 2% v/v
-