Information on EC 2.3.1.48 - histone acetyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.3.1.48
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RECOMMENDED NAME
GeneOntology No.
histone acetyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + histone = CoA + acetylhistone
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:histone acetyltransferase
A group of enzymes with differing specificities towards histone acceptors.
CAS REGISTRY NUMBER
COMMENTARY hide
9054-51-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
Artemia nauplii
3 enzyme forms: I, II and III
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
bat
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
zMoz
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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1100225 A+, 1100284 A+, 1100289 A+, 1100294 A+, 1100317 A+, 1100338 A+, 1658080 A+, 1658489 A+, 1887956 A+, 1888254 A+, 2296259 A+, 2296275 A+, 2296277 A+, 2712585 A+, 2912467 A+, 2912549 A+, 2912626 A+, 2912744 A+, 720291 A+, 1100130 A++, 1100163 A++, 1100172 A++, 1100197 A++, 1100206 A++, 1100223 A++, 1100231 A++, 1100233 A++, 1100237 A++, 1100253 A++, 1100262 A++, 1100267 A++, 1100347 A++, 1887861 A++, 1887895 A++, 1887897 A++, 1887932 A++, 1887953 A++, 1888014 A++, 1888022 A++, 1888134 A++, 1888169 A++, 1888334 A++, 2295967 A++, 2296037 A++, 2296078 A++, 2773848 A++, 2912556 A++, 2912606 A++, 2912609 A++, 2912713 A++, 702174 A++, 1100136 A++, 1100137 A++, 1100156 A++, 1100161 A++, 1132410 A++, 1184385 A++, 1229580 A++, 1273804 A++, 1276314 A++, 1364137 A++, 1660281 A++, 1660428 A++, 1887191 A++, 1887848 A++, 1887888 A++, 1887894 A++, 1887938 A++, 1887966 A++, 1887970 A++, 1887994 A++, 1888008 A++, 1888107 A++, 1888110 A++, 1888145 A++, 1888153 A++, 1888166 A++, 1888244 A++, 1888264 A++, 1888266 A++, 1888329 A++, 1888331 A++, 2295964 A++, 2296003 A++, 2296015 A++, 2296044 A++, 2296072 A++, 2296137 A++, 2296247 A++, 2389764 A++, 2532645 A++, 2670687 A++, 2730142 A++, 2912294 A++, 2912310 A++, 2912334 A++, 2912557 A++, 2912589 A++, 2912716 A++, 2912758 A++, 2912833 A++, 2912927 A++, 487092 A++, 659940 A++, 705688 A++, 955944 A++, 956742 A++, 972451 A++, 1100214 A+++, 1100221 A+++, 1100227 A+++, 1100295 A+++, 1100305 A+++, 1100307 A+++, 1100330 A+++, 1100344 A+++, 1100360 A+++, 1100177 A++++, 1100242 A++++, 1100309 A++++, 1100313 A++++, 675976 A++++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
Herpes simplex virus
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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1100255 A+, 1100274 A+, 1100328 A+, 1100357 A+, 1412588 A+, 1451831 A+, 1887981 A+, 1888200 A+, 1888217 A+, 1888246 A+, 1888297 A+, 1888312 A+, 1888382 A+, 2127726 A+, 2296202 A+, 2296210 A+, 2296217 A+, 2296243 A+, 2296246 A+, 2730346 A+, 2745207 A+, 2765435 A+, 2911880 A+, 2912648 A+, 2912673 A+, 2912851 A+, 2912859 A+, 2912881 A+, 2912959 A+, 2912971 A+, 2912975 A+, 776749 A+, 891622 A+, 1094502 A++, 1100169 A++, 1100170 A++, 1100220 A++, 1100252 A++, 1138058 A++, 1186667 A++, 1327983 A++, 1879720 A++, 1887926 A++, 1887976 A++, 1887989 A++, 1887995 A++, 1888032 A++, 1888055 A++, 1888071 A++, 1888183 A++, 1888214 A++, 1888271 A++, 2295593 A++, 2295616 A++, 2295995 A++, 2295996 A++, 2295997 A++, 2296005 A++, 2296024 A++, 2296029 A++, 2296046 A++, 2296056 A++, 2296057 A++, 2296063 A++, 2296065 A++, 2296082 A++, 2296098 A++, 2296103 A++, 2296108 A++, 2296118 A++, 2296133 A++, 2296150 A++, 2296160 A++, 2296177 A++, 2296206 A++, 2296253 A++, 2296265 A++, 2393137 A++, 2406843 A++, 2407248 A++, 2668789 A++, 2905565 A++, 2911895 A++, 2912310 A++, 2912332 A++, 2912352 A++, 2912409 A++, 2912417 A++, 2912423 A++, 2912425 A++, 2912437 A++, 2912446 A++, 2912450 A++, 2912455 A++, 2912468 A++, 2912493 A++, 2912507 A++, 2912510 A++, 2912521 A++, 2912557 A++, 2912596 A++, 2912609 A++, 2912629 A++, 2912646 A++, 2912657 A++, 2912724 A++, 2912756 A++, 2912774 A++, 2912821 A++, 2912873 A++, 2912916 A++, 2912925 A++, 2912945 A++, 703040 A++, 703368 A++, 706554 A++, 822650 A++, 1100151 A++, 1100183 A++, 1100186 A++, 1100205 A++, 1100239 A++, 1100285 A++, 1100326 A++, 1888182 A++, 2296085 A++, 2296095 A++, 2296100 A++, 2296170 A++, 2911831 A++, 2912525 A++, 2912658 A++, 2912922 A++, 705688 A++, 1100224 A+++, 1100256 A+++, 1100279 A+++, 889242 A+++, 1100325 A++++
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
protozoa
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Automatic Mining of ENzyme DAta
strain BY4705
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
GCN5
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Manually annotated by BRENDA team
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Automatic Mining of ENzyme DAta
Toxoplasma gondii ATCC 50611
Me49
UniProt
Manually annotated by BRENDA team
TgGCN5b
UniProt
Manually annotated by BRENDA team
trout
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
yeasts
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Automatic Mining of ENzyme DAta
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Automatic Mining of ENzyme DAta
Zea mays Cuzco
strain Cuzco
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4 acetyl-CoA + histone H4
4 CoA + tetraacetylhistone H4
show the reaction diagram
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NuA4 randomly acetylates free and nucleosomal H4, with a small preference for lysines 5, 8, and 12 over 16
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?
acetyl-CoA + 1,4-butanediamine
?
show the reaction diagram
acetyl-CoA + 1,5-pentanediamine
?
show the reaction diagram
acetyl-CoA + 1,6-hexanediamine
?
show the reaction diagram
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enzyme form A shows low activity , B not
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?
acetyl-CoA + beta-site amyloid precursor protein-cleaving enzyme 1
CoA + acetylated beta-site amyloid precursor protein-cleaving enzyme 1
show the reaction diagram
acetyl-CoA + c-Myc
CoA + acetylated c-Myc
show the reaction diagram
acetyl-CoA + H3 peptide
?
show the reaction diagram
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?
acetyl-CoA + histone
CoA + acetylhistone
show the reaction diagram
acetyl-CoA + histone H
CoA + acetylhistone H
show the reaction diagram
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histone acetyltransferase AtGCN5 is required to regulate the floral meristem activity through the WUS/AG pathway
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?
acetyl-CoA + histone H1
CoA + acetylhistone H1
show the reaction diagram
acetyl-CoA + histone H2A
CoA + acetylhistone H2A
show the reaction diagram
acetyl-CoA + histone H2A
Nalpha-acetylated-histone H2A + CoA
show the reaction diagram
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?
acetyl-CoA + histone H2B
CoA + acetylhistone H2B
show the reaction diagram
acetyl-CoA + histone H3
CoA + acetyl-histone H3
show the reaction diagram
acetyl-CoA + histone H3
CoA + acetylhistone
show the reaction diagram
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?
acetyl-CoA + histone H3
CoA + acetylhistone H3
show the reaction diagram
acetyl-CoA + histone H3
peptide CoA + acetylhistone H3 peptide
show the reaction diagram
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preferred substrate, the N-terminal substrate region plays an importsant role in enhanced affinity of the Gcn5/PCAF proteins for histone H3
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?
acetyl-CoA + histone H3 N-terminal tail
CoA + acetylated histone H3 N-terminal tail
show the reaction diagram
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50 mM Tris-HCl, pH 8.0, 30°C
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?
acetyl-CoA + histone H3 peptide
CoA + acetylhistone H3 peptide
show the reaction diagram
acetyl-CoA + histone H3 peptide
CoA + actylhistone H3
show the reaction diagram
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residues 1-21 of human histone H3
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acetyl-CoA + histone H3 tail peptide
CoA + acetylhistone H3 peptide
show the reaction diagram
H3 peptide substrate, amino acid sequence ARTKQTARKSTGGKAPRKQL
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?
acetyl-CoA + histone H4
CoA + acetylhistone H4
show the reaction diagram
acetyl-CoA + histone H4
CoA + diacetylhistone H4
show the reaction diagram
acetyl-CoA + histone H4
CoA + triacetylhistone H4
show the reaction diagram
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enzyme form B
mono-, di- and triacetylated products
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acetyl-CoA + histone H4
Nalpha-acetylated-histone H4 + CoA
show the reaction diagram
acetylation of N-terminal Ser
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?
acetyl-CoA + histone H4
peptide CoA + acetylhistone H4 peptide
show the reaction diagram
acetyl-CoA + histone H4 peptide
CoA + acetylhistone H4 peptide
show the reaction diagram
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a synthetic peptide corresponding to the first 20 amino acids of the histone H4 N-terminus
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?
acetyl-CoA + histone H4 peptide
CoA + acetylpeptide of histone H4
show the reaction diagram
residues 1-20 of histone H4
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?
acetyl-CoA + histone H4 peptide
CoA + actylhistone H4
show the reaction diagram
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residues 2-24 of human histone H4
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acetyl-CoA + NF-kB p65
CoA + acetyl-NF-kB p65
show the reaction diagram
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acetylation of the subunit at Lys310 by p300 or PCAF
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?
acetyl-CoA + non-histone chromatin high-mobility group protein
CoA + acetylated non-histone chromatin high-mobility group protein
show the reaction diagram
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or chymotryptic peptides of
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?
acetyl-CoA + p50 protein
CoA + acetyl-p50 protein
show the reaction diagram
acetyl-CoA + p53
CoA + acetyl-p53
show the reaction diagram
acetyl-CoA + p65 protein
CoA + acetyl-p65 protein
show the reaction diagram
acetyl-CoA + peptide H4-20
CoA + acetylpeptide H4-20
show the reaction diagram
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histone H4-derived peptide substrate
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?
acetyl-CoA + poly-L-lysine
CoA + N6-acetyllysine
show the reaction diagram
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enzyme form A, not enzyme form B1 and B2
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?
acetyl-CoA + protamine sulfate
?
show the reaction diagram
acetyl-CoA + protein p53
CoA + acetylprotein p53
show the reaction diagram
acetyl-CoA + spermidine
?
show the reaction diagram
acetyl-CoA + spermine
?
show the reaction diagram
acetyl-CoA + transcription factor TFIIE
CoA + acetylated transcription factor TFIIE
show the reaction diagram
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substrate is a basal transcription factor
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?
acetyl-CoA + transcription factor TFIIF
CoA + acetylated transcription factor TFIIF
show the reaction diagram
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substrate is a basal transcription factor
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activated RNA polymerase II transcriptional coactivator p15 + 4-pentynoyl-CoA
?
show the reaction diagram
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?
alpha-tubulin + acetyl-CoA
acetyl-alpha-tubulin + CoA
show the reaction diagram
androgen receptor + acetyl-CoA
acetylated androgen receptor + CoA
show the reaction diagram
ATM kinase + acetyl-CoA
acetylated ATM kinase + CoA
show the reaction diagram
H4 peptide + acetyl-CoA
?
show the reaction diagram
histone + acetyl-CoA
acetyl-histone + CoA
show the reaction diagram
histone + propionyl-CoA
propionyl-histone + CoA
show the reaction diagram
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?
histone H2A + acetyl-CoA
acetyl-histone H2A + CoA
show the reaction diagram
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acetylation of the tail of the histone, the enzyme is organized in the NuA4 subcomplex acting on the nucleosome, overview
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?
histone H2B + acetyl-CoA
acetyl-histone H2B + CoA
show the reaction diagram
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acetylation of the tail of the histone, the enzyme is organized in the catalytic Ada2/Ada3/Gcn5 subcomplex of SAGA acting on the nucleosome, overview
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?
histone H3 + acetyl-CoA
acetyl-histone H3 + CoA
show the reaction diagram
histone H3 tail peptide + acetyl-CoA
acetyl-histone H3 tail peptide + CoA
show the reaction diagram
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?
histone H3.2 + 4-pentynoyl-CoA
?
show the reaction diagram
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?
histone H4 + acetyl-CoA
acetyl-histone H4 + CoA
show the reaction diagram
histone H4 N-terminal peptide + acetyl-CoA
acetyl-histone H4 N-terminal peptide + CoA
show the reaction diagram
N-terminal peptide of histone H4 of different length and sequence, prepared in HeLa cell extract, overview, acetylation by Hat1 requires positively charged amino acids at positions 8 and 16 of the H4 tail, substituting glutamine for lysine at Lys8 and Lys16 dramatically reduces the ability of yHat1p to acetylate the H4 tail peptide, phosphorylation of Ser1 also reduces the acetylation of H4 peptides
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?
isoform 1 of DNA polymerase zeta catalytic subunit + 4-pentynoyl-CoA
?
show the reaction diagram
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?
isoform 1 of transcription factor BTF3 + 4-pentynoyl-CoA
?
show the reaction diagram
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?
isoform 2 of protein SET + 4-pentynoyl-CoA
?
show the reaction diagram
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?
isoform long of antigen KI-67 + 4-pentynoyl-CoA
?
show the reaction diagram
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?
nucleolin + 4-pentynoyl-CoA
?
show the reaction diagram
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?
piccoloNuA4 peptide + acetyl-CoA
acetyl-piccoloNuA4 peptide + CoA
show the reaction diagram
the peptide is part of the physiologic enzme complex, overview
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?
piccoloNuA4 peptide + propionyl-CoA
propionyl-piccoloNuA4 peptide + CoA
show the reaction diagram
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?
promyelotic leukemia zinc finger gene + acetyl-CoA
acetylated promyelotic leukemia zinc finger gene + CoA
show the reaction diagram
additional information
?
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