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Literature summary for 2.3.1.48 extracted from

  • Iizuka, M.; Takahashi, Y.; Mizzen, C.A.; Cook, R.G.; Fujita, M.; Allis, C.D.; Frierson, H.F.; Fukusato, T.; Smith, M.M.
    Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers (2009), Gene, 436, 108-114.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.48

Protein Variants

Protein Variants Comment Organism
additional information overexpression of the dominant-negative, catalytically inactive mutant Hbo1 causes reduced histone H4 acetylation in both HeLa and MCF-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleosome
-
 Homo sapiens 786
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H4 Homo sapiens HBO1 regulates global histone H4 acetylation CoA + acetylhistone H4
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
breast cancer cell
-
 Homo sapiens
-
fibroblast
-
 Homo sapiens
-
gastric cancer cell
-
 Homo sapiens
-
HFF2/T cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
additional information semiquantitative determination of enzyme in primary cancers of different tissues, overview. Hbo1 is approximately equimolar with the number of active replication origins in normal human fibroblasts but is an order of magnitude more abundant in both MCF7 and Saos-2 established cancer cell lines. Strong Hbo1 protein expression in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder Homo sapiens
-
ovary cancer cell
-
 Homo sapiens
-
SAOS-2 cell
-
 Homo sapiens
-
testicular cancer cell
-
 Homo sapiens
-
urinary bladder cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H4 HBO1 regulates global histone H4 acetylation Homo sapiens CoA + acetylhistone H4
-
 ?
acetyl-CoA + histone H4 recombinant Hbo1 can acetylate nucleosomal histone H4 in vitro, with a preference for Lys5 and Lys12, mapping of acetylation sites, overview Homo sapiens CoA + acetylhistone H4
-
 ?

Synonyms

Synonyms Comment Organism
HAT
-
 Homo sapiens
HBO1
-
 Homo sapiens
histone H4 acetyltransferase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function Hbo1 plays a role as chromatin factor serving as a positive regulator of DNA replication , chromatin structure plays an important role in DNA replication initiation Homo sapiens