physiological function |
a histone modifying complex, composed of the Lsy-12 MYST-type histone acetyltransferase, the Ing-family plant homeodomain protein Lsy-13, and plant homeodomain/bromodomain protein Lin-49, is required to first initiate and then actively maintain lateralized gene expression in the gustatory system. A combination of transcription factors, which recognize DNA in a sequence-specific manner, and a histone modifying enzyme complex are responsible for inducing and maintaining neuronal laterality. In lsy-12 mutants the normally ASER-specific gcy-5 gene is expressed bilaterally from the onset of its expression in threefold embryos |
Caenorhabditis elegans |