Literature summary for 2.3.1.48 extracted from

He, T.; Hong, S.Y.; Huang, L.; Xue, W.; Yu, Z.; Kwon, H.; Kirk, M.; Ding, S.J.; Su, K.; Zhang, Z.
Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity (2011), J. Biol. Chem., 286, 14137-14145.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293 cell	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
p300	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	co-expression of histone acetyltransferase E1A binding protein p300 dramatically enhances Pax5-mediated transcriptional activation. The p300-mediated enhancement is dependent on its intrinsic histone acetyltransferase activity. Moreover, p300 interacts with the C terminus of Pax5 and acetylates multiple lysine residues within the paired box DNA-binding domain of Pax5. Mutations of lysine residues 67 and 87/89 to alanine within Pax5 abolish p300-mediated enhancement of Pax5-induced Luc-CD19 reporter expression in HEK-293 cells	Homo sapiens

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Release 2023.1 (January 2023)