Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Saccharomyces cerevisiae | MYST-related histone acetyltransferase complex NuA4: required for cell growth, required for p53-dependent transcription activation in yeast, presumably through its Yng2 subunit, homolog of the tumor suppressor ING1. GNAT-related histone acetyltransferase complex SAGA can stimulate Gal4-VP16 activation in a manner dependent on HAT activity. D´SAGA can be recruited by several yeast activators. SAGA is targeted to promoter regions proximal to the activator binding site. Once targeted, SAGA acetylates histone h3 in the vicinity of the promoter. Targeted acetylation by SAGA stabilizes its binding and that of a targeted SWI/SNF chromatin-remodeling complex. SAGA is required for both activation of the yeast ARG1 promoter by Gcn4 activator and repression by the ArgR/Mcm1 repressor complex | ? | - |
? | |
additional information | Homo sapiens | MYST-related histone acetyltransferase complex Tip60 also acts as a transcriptional coactivator in several systems including class I nuclear hormone receptors, NF-kappaB and at the superoxide dismutase gene. Tip 60 has been implicated in Alzheimer disease because it stimulates transcription when asociated with the cleaved cytoplasmic tail fragment of the amyloid-beta precursor protein | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H2A | MYST-related histone acetyltransferase complex Tip60 | Homo sapiens | CoA + acetylhistone H2A | - |
? | |
acetyl-CoA + histone H2B | GNAT-related histone acetyltransferase complexes SAGA, ADA or H2B | Saccharomyces cerevisiae | CoA + acetylhistone H2B | - |
? | |
acetyl-CoA + histone H2B | GNAT-related histone acetyltransferase complexes STAGA or TFTC | Homo sapiens | CoA + acetylhistone H2B | - |
? | |
acetyl-CoA + histone H3 | GNAT-related histone acetyltransferase complexes PCAF, STAGA or TFTC | Homo sapiens | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H3 | GNAT-related histone acetyltransferase complexes SAGA, ADA or HAT-A2, MYST-related histone acetyltransferase complex NuA3 | Saccharomyces cerevisiae | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | MYST-related histone acetyltransferase complex NuA4 or SAS(SAS-I) | Saccharomyces cerevisiae | CoA + acetylhistone H4 | - |
? | |
acetyl-CoA + histone H4 | MYST-related histone acetyltransferase complex Tip60, GNAT-related histone acetyltransferase complex PCAF | Homo sapiens | CoA + acetylhistone H4 | - |
? | |
additional information | MYST-related histone acetyltransferase complex NuA4: required for cell growth, required for p53-dependent transcription activation in yeast, presumably through its Yng2 subunit, homolog of the tumor suppressor ING1. GNAT-related histone acetyltransferase complex SAGA can stimulate Gal4-VP16 activation in a manner dependent on HAT activity. D´SAGA can be recruited by several yeast activators. SAGA is targeted to promoter regions proximal to the activator binding site. Once targeted, SAGA acetylates histone h3 in the vicinity of the promoter. Targeted acetylation by SAGA stabilizes its binding and that of a targeted SWI/SNF chromatin-remodeling complex. SAGA is required for both activation of the yeast ARG1 promoter by Gcn4 activator and repression by the ArgR/Mcm1 repressor complex | Saccharomyces cerevisiae | ? | - |
? | |
additional information | MYST-related histone acetyltransferase complex Tip60 also acts as a transcriptional coactivator in several systems including class I nuclear hormone receptors, NF-kappaB and at the superoxide dismutase gene. Tip 60 has been implicated in Alzheimer disease because it stimulates transcription when asociated with the cleaved cytoplasmic tail fragment of the amyloid-beta precursor protein | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GNAT-related histone acetyltransferase complex | PCAF, STAGA or TFTC | Homo sapiens |
GNAT-related histone acetyltransferase complex | SAGA, ADA or HAT-A2 | Saccharomyces cerevisiae |
MYST-related histone acetyltransferase complex | NuA4, NuA3 or ASA(SAS-I) | Saccharomyces cerevisiae |
MYST-related histone acetyltransferase complex | Tip60 | Homo sapiens |