Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.48 extracted from

  • Zhang, P.; Liu, Y.; Jin, C.; Zhang, M.; Tang, F.; Zhou, Y.
    Histone acetyltransferase GCN5 regulates osteogenic differentiation of mesenchymal stem cells by inhibiting NF-kappaB (2015), J. Bone Miner. Res., 31, 391-402.
    View publication on PubMed
Search for more literature for 2.3.1.48

Application

Application Comment Organism
pharmacology the GCN5-NF-kB pathway is a potentialmolecular target for stem cell mediated regenerative medicine and the treatment of metabolic bone diseases such as osteoporosis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow decreased GCN5 in osteoporotic bone marrow Mus musculus
-
additional information expression of GCN5 is decreased significantly in the bone tissue sections of ovariectomized mice or aged mice Mus musculus
-

Synonyms

Synonyms Comment Organism
Gcn5
-
 Mus musculus
general control nonderepressible 5
-
 Mus musculus
HAT
-
 Mus musculus

General Information

General Information Comment Organism
malfunction knockdown of GCN5 inhibits the osteogenic differentiation of and mineralization in mesenchymal stem cells. Impaired osteogenic differentiation by GCN5 knockdown is blocked by inhibition of NF-kappaB Mus musculus
physiological function the enzyme GCN5 plays essential roles in various developmental processes, it has a critical function in osteogenic commitment of mesenchymal stem cells. In this role, the histone acetyltransferase activity of GCN5 is not required. Enzyme GCN5 represses nuclear factor kappa B-dependent transcription and inhibits the NF-kappaB signaling pathway. GCN5 is responsible for degradation of RelA. Acetylase activity of GCN5 is dispensable for the regulation of osteogenic differentiation of mesenchymal stem cells Mus musculus