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Literature summary for 2.3.1.48 extracted from

  • Cai, Y.; Jin, J.; Swanson, S.K.; Cole, M.D.; Choi, S.H.; Florens, L.; Washburn, M.P.; Conaway, J.W.; Conaway, R.C.
    Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex (2009), J. Biol. Chem., 285, 4268-4272.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.48

Cloned(Commentary)

Cloned (Comment) Organism
stable overexpression of FLAG-tagged MOF-conbtaining complex subunits in HEK293/FRT or HeLa S3 cells, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleosome
-
 Homo sapiens 786
-
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H4 Homo sapiens MSL-associated MOF acetylates nucleosomal histone H4 almost exclusively on Lys16, while NSL-associated MOF exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on Lys5 and Lys8 CoA + acetylhistone H4
-
 ?
additional information Homo sapiens besides the male-specific lethal, MSL, HAT complex, MOF is also a component of the second HAT complex, designated the non-specific lethal, NSL complex, substrate specificity of the NSL complex, overview. Assembly of the MOF HAT into MSL or NSL complexes controls its substrate specificity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 MOF
-
Homo sapiens Q9H7Z6 catalytic subunit of the male-specific lethal hiostone acetyltransferase complex
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H4
-
 Homo sapiens CoA + acetylhistone H4
-
 ?
acetyl-CoA + histone H4 MSL-associated MOF acetylates nucleosomal histone H4 almost exclusively on Lys16, while NSL-associated MOF exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on Lys5 and Lys8 Homo sapiens CoA + acetylhistone H4
-
 ?
additional information besides the male-specific lethal, MSL, HAT complex, MOF is also a component of the second HAT complex, designated the non-specific lethal, NSL complex, substrate specificity of the NSL complex, overview. Assembly of the MOF HAT into MSL or NSL complexes controls its substrate specificity Homo sapiens ?
-
 ?
additional information no activity with histones H3, H2A and H2B by recombinant MOF in HeLa nucleosomes Homo sapiens ?
-
 ?
additional information assembly of the enzyme into male-specific lethal, MSL, or non-specific lethal, NSL, complexes controls its substrate specificity. Although MSL-associated enzyme acetylates nucleosomal histone H4 almost exclusively on lysine 16, NSL-associated enzyme exhibits a relaxed specificity and also acetylates nucleosomal histone H4 on lysines 5 and 8 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More besides the male-specific lethal, MSL, HAT complex, MOF is also a component of the second HAT complex, designated the non-specific lethal, NSL complex, subunit composition of the NSL complex, overview. Two of its subunits,WD repeat domain 5, WDR5, and host cell factor 1, HCF1, are shared with members of the MLL/SET family of histone H3 lysine 4 methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex Homo sapiens
More enzyme is the catalytic subunit of the male-specific lethal hiostone acetyltransferase complex NSL, which is composed of nine subunits. Two of its subunits,WD-repeat domain WDR5 and host cell factor HCF1, are shared with members of the MLL/SET family of histone H3 lysine 4 methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. Assembly of the enzyme into MSL or NSL complexes controls its substrate specificity Homo sapiens

Synonyms

Synonyms Comment Organism
Mof
-
 Homo sapiens
More MOF is a member of the MYST, i.e. Moz-Ybf2/Sas3-Sas2-Tip60, family of histone acetyltransferases, HATs Homo sapiens
MYST1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Homo sapiens