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Literature summary for 2.3.1.48 extracted from

  • Ginsburg, D.S.; Govind, C.K.; Hinnebusch, A.G.
    NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5 (2009), Mol. Cell. Biol., 29, 6473-6487.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.48

Activating Compound

Activating Compound Comment Organism Structure
methylated histone stimulates interaction of NuA4 complex with histone Saccharomyces cerevisiae
NuA4 cooperation with the NuA4 complex to enhance its functions but independent contribution to acetylation Saccharomyces cerevisiae
SAGA cooperation with the Gcn5 complex to enhance its functions but independent contribution to acetylation Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
L254P esa1 mutant (reduced histone H4 acetylation) at 36°C (restrictive temperature) is sensitive to 6-azauracil (inhibitor impeding elongation by lowering nucleotide pools) but shows little effect at 30°C (permissive temperature), gene length dependent defects in transcription Saccharomyces cerevisiae
additional information double mutant esa1/gcn5 at 36°C is very sensitive to 6-azauracil (inhibitor impeding elongation by lowering nucleotide pools) and shows littler but still strong effect at 30°C (permissive temperature), gene length dependent defects in transcription Saccharomyces cerevisiae
additional information gcn5 deletion mutant (reduced H3 acetylation) at 36°C (restrictive temperature) is very sensitive to 6-azauracil (inhibitor impeding elongation by lowering nucleotide pools) but shows less effect at 30°C (permissive temperature), gene length dependent defects in transcription Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone Saccharomyces cerevisiae
-
 CoA + acetylhistone
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 wild-type strain BY4741 and deletion derivatives
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone
-
 Saccharomyces cerevisiae CoA + acetylhistone
-
 ?

Synonyms

Synonyms Comment Organism
Esa1
-
 Saccharomyces cerevisiae
Gcn5
-
 Saccharomyces cerevisiae
H4 lysine acetyltransferase
-
 Saccharomyces cerevisiae
KAT
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function Esa1 mediates increased H4 acetylation and enhanced chromatin remodeling complex RSC occupancy and histone eviction in coding sequences and stimulates the rate of transcription elongation by polymerase II Saccharomyces cerevisiae