Cloned (Comment) | Organism |
---|---|
expression of MORF protein as FLAG-tagged protein in Sf9 insect cells via baculovirus infection, and as Gal4-fusion protein in 293T cells, amino acid sequence | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
MORF protein contains histone acetyltransferase, and transcription activating and repressing domains | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
MORF protein, i.e. monocytic leukemia zinc finger protein-related factor | - |
Homo sapiens | Q8WYB5 | fragment EST clone of MORF protein, i.e. monocytic leukemia zinc finger protein-related factor | - |
Purification (Comment) | Organism |
---|---|
recombinant from Sf9 insect cells via baculovirus infection, FLAG-tagged MORF protein | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine | acetylation of lysine 5, 8, 12, and 16 of free histone H4 | Homo sapiens | |
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine | mechanisms | Homo sapiens | |
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine | MORF protein is also active as transcription factor | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
monocyte | leukemic | Homo sapiens | - |
additional information | ubiquitous expression of MORF protein in human tissue | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone | calf thymus and HeLa cell histones | Homo sapiens | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms | Homo sapiens | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone H3 | - |
Homo sapiens | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | histone H4 is the preferred substrate | Homo sapiens | CoA + acetylhistone H4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Homo sapiens |
More | enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
MORF protein, assay at | Homo sapiens |