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Literature summary for 2.3.1.48 extracted from

  • Dekker, F.J.; Ghizzoni, M.; van der Meer, N.; Wisastra, R.; Haisma, H.J.
    Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones (2009), Bioorg. Med. Chem., 17, 460-466.
    View publication on PubMed
Search for more literature for 2.3.1.48

Inhibitors

Inhibitors Comment Organism Structure
2-(3-chloro-4-fluorophenyl)isothiazol-3(2H)-one
-
 Homo sapiens
2-ethylisothiazol-3(2H)-one
-
 Homo sapiens
2-pentylisothiazol-3(2H)-one
-
 Homo sapiens
5-chloro-2-(3-chloro-4-fluorophenyl)isothiazol-3(2H)-one
-
 Homo sapiens
5-chloro-2-ethylisothiazol-3(2H)-one
-
 Homo sapiens
5-chloro-2-pentylisothiazol-3(2H)-one
-
 Homo sapiens
benzyl [2-(5-chloro-3-oxoisothiazol-2(3H)-yl)ethyl]carbamate
-
 Homo sapiens
ethyl 3-(5-chloro-3-oxoisothiazol-2(3H)-yl)propanoate
-
 Homo sapiens
methyl 2-(5-chloro-3-oxoisothiazol-2(3H)-yl)ethanoate
-
 Homo sapiens
methyl 3-(3-oxoisothiazol-2(3H)-yl)propanoate
-
 Homo sapiens
methyl 3-(5-chloro-1-oxido-3-oxoisothiazol-2(3H)-yl)propanoate
-
 Homo sapiens
methyl 3-(5-chloro-3-oxoisothiazol-2(3H)-yl)propanoic acid
-
 Homo sapiens
methyl 3-[(5-chloroisothiazol-3-yl)amino]propanoate
-
 Homo sapiens
methyl 3-[4-{[(benzyloxy)carbonyl]amino}-5-chloro-3-oxoisothiazol-2(3H)-yl]propanoate
-
 Homo sapiens
methyl 4-(3-oxoisothiazol-2(3H)-yl)butanoate
-
 Homo sapiens
methyl 4-(5-chloro-3-oxoisothiazol-2(3H)-yl)butanoate
-
 Homo sapiens
methyl 5-(5-chloro-3-oxoisothiazol-2(3H)-yl)pentanoate
-
 Homo sapiens
methyl 6-(5-chloro-3-oxoisothiazol-2(3H)-yl)hexanoate
-
 Homo sapiens
additional information 5-chloroisothiazoline inhibitors: design, synthesis and study of inhibitory potencies and inhibition of cell growth, molecular modeling, overview; N-methyl-5-chloroisothiazolone/N-methylisothiazolone in a ratio of 3:1 in Kathon TM CG, a preservative in cosmetics, that inhibits PCAF and the growth of cell lines A2780 and HEK-293 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92831
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-2780 cell
-
 Homo sapiens
-
commercial preparation
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3
-
 Homo sapiens CoA + acetylhistone H3
-
 ?

Synonyms

Synonyms Comment Organism
HAT
-
 Homo sapiens
histone acetyl transferase
-
 Homo sapiens
p300/CBP associated factor
-
 Homo sapiens
PCAF
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Homo sapiens