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Literature summary for 2.3.1.48 extracted from
- The double-histone-acetyltransferase complex ATAC is essential for mammalian development (2009), Mol. Cell. Biol., 29, 1176-1188.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| ATAC2, DNA and amino acid sequence determination and analysis, Atac2 fused to two HA and two FLAG tags is stably expressed in nuclei of HEK-293 cells and in murine C2C12 cells | Homo sapiens |
| ATAC2, genotyping | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | depletion of ATAC2 results in the disassembly of the ATAC complex. Loss of Atac2 leads to reduced histone acetylation, cell death, and G2/M arrest | Homo sapiens |
| additional information | generation of ATAC2-knockout mice, loss of Atac2 leads to reduced histone acetylation, cell death, and G2/M arrest | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | ATAC2 associates with GCN5 and other proteins linked to chromatin metabolism | ? | - |
? |  |
| additional information | Homo sapiens | ATAC2 associates with GCN5 and other proteins linked to chromatin metabolism | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9H8E8 | ATAC2 | - |
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant Atac2 fused to two HA and two FLAG tags from nuclear extracts of HEK-293 cells and murine C2C12 cells by M2-agarose affinity chromatography and gel filtration | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + histone H4 | recombinant ATAC2 has a weak HAT activity directed to histone H4 | Mus musculus | CoA + acetylhistone H4 | - |
? | |
| acetyl-CoA + histone H4 | recombinant ATAC2 has a weak HAT activity directed to histone H4 | Homo sapiens | CoA + acetylhistone H4 | - |
? | |
| additional information | ATAC2 associates with GCN5 and other proteins linked to chromatin metabolism | Mus musculus | ? | - |
? | |
| additional information | ATAC2 associates with GCN5 and other proteins linked to chromatin metabolism | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | ATAC2, mass spectrometric analysis | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ATAC2 | - |
Mus musculus |
| ATAC2 | - |
Homo sapiens |
| Gcn5 | - |
Mus musculus |
| Gcn5 | - |
Homo sapiens |
| HAT | - |
Mus musculus |
| HAT | - |
Homo sapiens |
| More | part of the double-histone-acetyltransferase complex ATAC, ADA2A-containing complex | Mus musculus |
| More | part of the double-histone-acetyltransferase complex ATAC, ADA2A-containing complex | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.9 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Mus musculus | |
| acetyl-CoA | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ATAC2 not only carries out an enzymatic function but also plays an architectural role in the stability of mammalian ATAC | Mus musculus |
| physiological function | ATAC2 not only carries out an enzymatic function but also plays an architectural role in the stability of mammalian ATAC | Homo sapiens |
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