Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.48 extracted from

  • Kim, W.; Benhamed, M.; Servet, C.; Latrasse, D.; Zhang, W.; Delarue, M.; Zhou, D.X.
    Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis (2009), Cell Res., 19, 899-909.
    View publication on PubMed
Search for more literature for 2.3.1.48

Protein Variants

Protein Variants Comment Organism
additional information construction of T-DNA insertion gcn5 mutants, levels of accumulated miRNAs are increased in gcn5-2 mutant compared to the wild-type enzyme, targets of the increased miRNAs are e.g. DCL1 and AGO1, phenotypes, overview Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Arabidopsis thaliana 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana histone acetylation and deacetylation is an epigenetic mechanism in volved in regulation of mIRNA production. GCN5 has a general repressive effect on microRNAs, miRNAs, and it targets a subset of MIRNA genes, GCN5 is required for acetylation of histone H3 lysine 14 at these loci, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
 ecotype Wassilewskija, genes gcn5-1 and gcn5-2
-

Source Tissue

Source Tissue Comment Organism Textmining
inflorescence
-
 Arabidopsis thaliana
-
seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3 acetylation at Lys14 of histone H3 Arabidopsis thaliana CoA + acetylhistone H3
-
 ?
additional information histone acetylation and deacetylation is an epigenetic mechanism in volved in regulation of mIRNA production. GCN5 has a general repressive effect on microRNAs, miRNAs, and it targets a subset of MIRNA genes, GCN5 is required for acetylation of histone H3 lysine 14 at these loci, overview Arabidopsis thaliana ?
-
 ?

Synonyms

Synonyms Comment Organism
Gcn5
-
 Arabidopsis thaliana
general control non-repressed protein5
-
 Arabidopsis thaliana
histone acetyltransferase
-
 Arabidopsis thaliana
More GCN5 belongs to the HAT family of enzymes Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function GCN5 has a general repressive effect on microRNAs, miRNAs, that guide sequence-specific posttranscriptional gene silencing, but is required for expression of a subset of MIRNA genes, overview Arabidopsis thaliana