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Literature summary for 2.3.1.48 extracted from

  • Fillingham, J.; Recht, J.; Silva, A.C.; Suter, B.; Emili, A.; Stagljar, I.; Krogan, N.J.; Allis, C.D.; Keogh, M.C.; Greenblatt, J.F.
    Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109 (2008), Mol. Cell. Biol., 28, 4342-4353.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Asf1 a histone chaperone that activates the enzyme Saccharomyces cerevisiae
VPS75 Rtt109's H3-K9 acetylation activity in vitro is enhanced strongly by histone chaperone Vps75, Asf1, and Vps75 are both required for acetylation of Lys9 on H3 in vivo by Rtt109, whereas acetylation of Lys56 on H3 in vivo requires only Asf1 Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information deletion of either ASF1 or RTT109 in cycling cells ablates H3-K56 acetylation and leads to elevated levels of DNA damage-associated gammaH2A and Rad53 phopshorylation Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Saccharomyces cerevisiae 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H3 Saccharomyces cerevisiae Rtt109 is specific for histone H3, acetylation at Lys9 and Lys56. RTT109 has functions in addition to maintaining genome stability CoA + acetylhistone H3
-
?
additional information Saccharomyces cerevisiae in addition to Asf1, Rtt109 is also functionally linked to Rtt101, Mms1, and Mms22 ?
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native Rtt109, in complex with the histone chaperone Vps75 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3 Rtt109 is specific for histone H3, acetylation at Lys9 and Lys56. RTT109 has functions in addition to maintaining genome stability Saccharomyces cerevisiae CoA + acetylhistone H3
-
?
acetyl-CoA + histone H3 Rtt109 is specific for histone H3, acetylation at Lys9 and Lys56 Saccharomyces cerevisiae CoA + acetylhistone H3
-
?
additional information in addition to Asf1, Rtt109 is also functionally linked to Rtt101, Mms1, and Mms22 Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
histone H3 acetyltransferase
-
Saccharomyces cerevisiae
Rtt109
-
Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function Rtt109 is important for repairing replication-associated lesions and has functions in addition to maintaining genome stability Saccharomyces cerevisiae