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Literature summary for 2.3.1.48 extracted from

  • Benson, L.J.; Phillips, J.A.; Gu, Y.; Parthun, M.R.; Hoffman, C.S.; Annunziato, A.T.
    Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair (2007), J. Biol. Chem., 282, 836-842.
    View publication on PubMed
Search for more literature for 2.3.1.48

Protein Variants

Protein Variants Comment Organism
additional information deletion of the hat1 gene from Schizosaccharomyces pombe causes increased sensitivity to the DNA-damaging agent methyl methanesulfonate in the absence of any additional mutations Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H4 + acetyl-CoA Schizosaccharomyces pombe
-
 acetyl-histone H4 + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe Q9UTM7 several strains, overview, gene HAT1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H4 + acetyl-CoA
-
 Schizosaccharomyces pombe acetyl-histone H4 + CoA
-
 ?
histone H4 + acetyl-CoA acetylation at Lys5 and Lys12, acetylation by Hat1 requires positively charged amino acids at positions 8 and 16 of the H4 tail Schizosaccharomyces pombe acetyl-histone H4 + CoA
-
 ?
histone H4 N-terminal peptide + acetyl-CoA N-terminal peptide of histone H4 of different length and sequence, prepared in HeLa cell extract, overview, acetylation by Hat1 requires positively charged amino acids at positions 8 and 16 of the H4 tail, substituting glutamine for lysine at Lys8 and Lys16 dramatically reduces the ability of yHat1p to acetylate the H4 tail peptide, phosphorylation of Ser1 also reduces the acetylation of H4 peptides Schizosaccharomyces pombe acetyl-histone H4 N-terminal peptide + CoA
-
 ?
additional information substrate specificity and order of acetylation of histone H4 by Hat1, overview Schizosaccharomyces pombe ?
-
 ?

Synonyms

Synonyms Comment Organism
HAT-B
-
 Schizosaccharomyces pombe
Hat1
-
 Schizosaccharomyces pombe
type B histone acetyltransferase
-
 Schizosaccharomyces pombe

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Schizosaccharomyces pombe

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Schizosaccharomyces pombe

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Schizosaccharomyces pombe