3.4.23.B14: plasmepsin IV
This is an abbreviated version!
For detailed information about plasmepsin IV, go to the full flat file.
Word Map on EC 3.4.23.B14
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3.4.23.B14
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plasmepsins
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plasmodium
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falciparum
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malaria
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vacuole
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hemoglobin
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antimalarial
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cathepsin
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vivax
-
ovale
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intraerythrocytic
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medicine
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peptidomimetic
-
berghei
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hydroxyethylamine
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allophenylnorstatine
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histo-aspartic
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proplasmepsins
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analysis
- 3.4.23.B14
-
plasmepsins
- plasmodium
- falciparum
- malaria
- vacuole
- hemoglobin
-
antimalarial
- cathepsin
- vivax
- ovale
-
intraerythrocytic
- medicine
-
peptidomimetic
- berghei
-
hydroxyethylamine
-
allophenylnorstatine
-
histo-aspartic
-
proplasmepsins
- analysis
Reaction
cleavage of hemoglobin. In the S3 and S2 subsites, the plasmepsin 4 orthologs all prefer hydrophobic amino acid residues, Phe or Ile, but reject charged residues such as Lys or Asp. In S2' and S3' subsites these plasmepsins tolerate both hydrophobic and hydrophilic residues =
Synonyms
A01.059, PfPM4, PgPM4, plasmepsin 4, Plm IV, PM IV, PM-IV, PM4, PMIV, PmPM4, PoPM4, pPM IV, proplasmepsin IV, PSM4, PvPM4
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Reference on EC 3.4.23.B14 - plasmepsin IV
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wyatt, D.M.; Berry, C.
Activity and inhibition of plasmepsin IV, a new aspartic proteinase from the malaria parasite, Plasmodium falciparum
FEBS Lett.
513
159-162
2002
Plasmodium falciparum (Q8IM16), Plasmodium falciparum
Dame, J.B.; Yowell, C.A.; Omara-Opyene, L.; Carlton, J.M.; Cooper, R.A.; Li, T.
Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. Infecting man
Mol. Biochem. Parasitol.
130
1-12
2003
Plasmodium falciparum (Q8IM16), Plasmodium falciparum
Nezami, A.; Kimura, T.; Hidaka, K.; Kiso, A.; Liu, J.; Kiso, Y.; Goldberg, D.E.; Freire, E.
High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor
Biochemistry
42
8459-8464
2003
Plasmodium falciparum (Q8IM16), Plasmodium falciparum
Clemente, J.C.; Govindasamy, L.; Madabushi, A.; Fisher, S.Z.; Moose, R.E.; Yowell, C.A.; Hidaka, K.; Kimura, T.; Hayashi, Y.; Kiso, Y.; Agbandje-McKenna, M.; Dame, J.B.; Dunn, B.M.; McKenna, R.
Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor
Acta Crystallogr. Sect. D
D62
246-252
2006
Plasmodium malariae
Madabushi, A.; Chakraborty, S.; Fisher, S.Z.; Clemente, J.C.; Yowell, C.; Agbandje-McKenna, M.; Dame, J.B.; Dunn, B.M.; McKenna, R.
Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae
Acta Crystallogr. Sect. F
61
228-231
2005
Plasmodium falciparum
Andrews, K.T.; Fairlie, D.P.; Madala, P.K.; Ray, J.; Wyatt, D.M.; Hilton, P.M.; Melville, L.A.; Beattie, L.; Gardiner, D.L.; Reid, R.C.; Stoermer, M.J.; Skinner-Adams, T.; Berry, C.; McCarthy, J.S.
Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria
Antimicrob. Agents Chemother.
50
639-648
2006
Plasmodium falciparum
Gutierrez-de-Teran, H.; Nervall, M.; Ersmark, K.; Liu, P.; Janka, L.K.; Dunn, B.; Hallberg, A.; Aqvist, J.
Inhibitor binding to the plasmepsin IV aspartic protease from Plasmodium falciparum
Biochemistry
45
10529-10541
2006
Plasmodium falciparum
Ersmark, K.; Nervall, M.; Gutierrez-de-Teran, H.; Hamelink, E.; Janka, L.K.; Clemente, J.C.; Dunn, B.M.; Gogoll, A.; Samuelsson, B.; Qvist, J.; Hallberg, A.
Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV
Bioorg. Med. Chem.
14
2197-2208
2006
Plasmodium falciparum
Kim, Y.M.; Lee, M.H.; Piao, T.G.; Lee, J.W.; Kim, J.H.; Lee, S.; Choi, K.M.; Jiang, J.H.; Kim, T.U.; Park, H.
Prodomain processing of recombinant plasmepsin II and IV, the aspartic proteases of Plasmodium falciparum, is auto- and trans-catalytic
J. Biochem.
139
189-195
2006
Plasmodium falciparum
Liu, J.; Gluzman, I.Y.; Drew, M.E.; Goldberg, D.E.
The role of Plasmodium falciparum food vacuole plasmepsins
J. Biol. Chem.
280
1432-1437
2005
Plasmodium falciparum
Ersmark, K.; Samuelsson, B.; Hallberg, A.
Plasmepsins as potential targets for new antimalarial therapy
Med. Res. Rev.
26
626-666
2006
Plasmodium falciparum
Li, T.; Yowell, C.A.; Beyer, B.B.; Hung, S.H.; Westling, J.; Lam, M.T.; Dunn, B.M.; Dame, J.B.
Recombinant expression and enzymatic subsite characterization of plasmepsin 4 from the four Plasmodium species infecting man
Mol. Biochem. Parasitol.
135
101-109
2004
Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale
Luksch, T.; Chan, N.S.; Brass, S.; Sotriffer, C.A.; Klebe, G.; Diederich, W.E.
Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors
ChemMedChem
3
1323-1336
2008
Plasmodium falciparum
Janka, L.; Clemente, J.; Vaiana, N.; Sparatore, A.; Romeo, S.; Dunn, B.M.
Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors
Protein Pept. Lett.
15
868-873
2008
Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale
Spaccapelo, R.; Janse, C.J.; Caterbi, S.; Franke-Fayard, B.; Bonilla, J.A.; Syphard, L.M.; Di Cristina, M.; Dottorini, T.; Savarino, A.; Cassone, A.; Bistoni, F.; Waters, A.P.; Dame, J.B.; Crisanti, A.
Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria
Am. J. Pathol.
176
205-217
2010
Plasmodium berghei
Luksch, T.; Blum, A.; Klee, N.; Diederich, W.E.; Sotriffer, C.A.; Klebe, G.
Pyrrolidine derivatives as plasmepsin inhibitors: binding mode analysis assisted by molecular dynamics simulations of a highly flexible protein
ChemMedChem
5
443-454
2010
Plasmodium falciparum
Marcoux, J.; Thierry, E.; Vives, C.; Signor, L.; Fieschi, F.; Forest, E.
Investigating alternative acidic proteases for H/D exchange coupled to mass spectrometry: plasmepsin 2 but not plasmepsin 4 is active under quenching conditions
J. Am. Soc. Mass Spectrom.
21
76-79
2010
Plasmodium falciparum
Li, F.; Patra, K.P.; Yowell, C.A.; Dame, J.B.; Chin, K.; Vinetz, J.M.
Apical surface expression of aspartic protease plasmepsin 4, a potential transmission-blocking target of the Plasmodium ookinete
J. Biol. Chem.
285
8076-8083
2010
Plasmodium gallinaceum
Silva, N.; Lameira, J.; Alves, C.
A quantum mechanical/molecular mechanical study of the aspartic protease plasmepsin IV complexed with allophenylnorstatine-based inhibitor
Chem. Phys. Lett.
509
169-174
2011
Plasmodium malariae (O60990)
-
Moon, S.U.; Kang, J.M.; Kim, T.S.; Kong, Y.; Sohn, W.M.; Na, B.K.
Plasmodium vivax: collaborative roles for plasmepsin 4 and vivapains in hemoglobin hydrolysis
Exp. Parasitol.
128
127-132
2011
Plasmodium vivax (O60989), Plasmodium vivax
Rawat, M.; Vijay, S.; Gupta, Y.; Dixit, R.; Tiwari, P.K.; Sharma, A.
Sequence homology and structural analysis of plasmepsin 4 isolated from Indian Plasmodium vivax isolates
Infect. Genet. Evol.
11
924-933
2011
Plasmodium vivax (D4P4R3), Plasmodium vivax
Recacha, R.; Jaudzems, K.; Akopjana, I.; Jirgensons, A.; Tars, K.
Crystal structure of Plasmodium falciparum proplasmepsin IV the plasticity of proplasmepsins
Acta Crystallogr. Sect. F
72
659-666
2016
Plasmodium falciparum (Q8IM16), Plasmodium falciparum
Mishra, V.; Rathore, I.; Arekar, A.; Sthanam, L.K.; Xiao, H.; Kiso, Y.; Sen, S.; Patankar, S.; Gustchina, A.; Hidaka, K.; Wlodawer, A.; Yada, R.Y.; Bhaumik, P.
Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights
FEBS J.
285
3077-3096
2018
Plasmodium falciparum
Huizing, A.P.; Mondal, M.; Hirsch, A.K.
Fighting malaria structureguided discovery of nonpeptidomimetic plasmepsin inhibitors
J. Med. Chem.
58
5151-5163
2015
Plasmodium falciparum
Rasina, D.; Otikovs, M.; Leitans, J.; Recacha, R.; Borysov, O.V.; Kanepe-Lapsa, I.; Domraceva, I.; Pantelejevs, T.; Tars, K.; Blackman, M.J.; Jaudzems, K.; Jirgensons, A.
Fragment-based discovery of 2-aminoquinazolin-4(3H)-ones as novel class nonpeptidomimetic inhibitors of the plasmepsins I, II, and IV
J. Med. Chem.
59
374-387
2016
Plasmodium falciparum (Q8IM16)
Singh, A.K.; Rathore, S.; Tang, Y.; Goldfarb, N.E.; Dunn, B.M.; Rajendran, V.; Ghosh, P.C.; Singh, N.; Latha, N.; Singh, B.K.; Rawat, M.; Rathi, B.
Hydroxyethylamine based phthalimides as new class of plasmepsin hits design, synthesis and antimalarial evaluation
PLoS ONE
10
e0139347
2015
Plasmodium falciparum
Liu, P.; Robbins, A.H.; Marzahn, M.R.; McClung, S.H.; Yowell, C.A.; Stevens, S.M.; Dame, J.B.; Dunn, B.M.
Enzymatic characterization of recombinant food vacuole plasmepsin 4 from the rodent malaria parasite Plasmodium berghei
PLoS ONE
10
e0141758
2015
Plasmodium berghei
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