Literature summary for 3.4.23.B14 extracted from

Li, F.; Patra, K.P.; Yowell, C.A.; Dame, J.B.; Chin, K.; Vinetz, J.M.
Apical surface expression of aspartic protease plasmepsin 4, a potential transmission-blocking target of the Plasmodium ookinete (2010), J. Biol. Chem., 285, 8076-8083.

Search for more literature for 3.4.23.B14

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	peptidomimetic and natural product aspartic protease inhibitors, calpain inhibitors, and anti-PgPM4 monoclonal antibodies significantly reduce parasite infectivity for mosquitoes	Plasmodium gallinaceum
N-acetyl-Leu-Leu-Met-CHO	calpaicin inhibitor II	Plasmodium gallinaceum
N-acetyl-Leu-Leu-norleucinal	calpaicin inhibitor I	Plasmodium gallinaceum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
digestive vacuole	of asexual stage malaria parasites	Plasmodium gallinaceum	-	-
extracellular	ookinete-secreted plasmepsin 4	Plasmodium gallinaceum	-	-
microneme	-	Plasmodium gallinaceum	20009	-
additional information	co-localization of PgPM4 with chitinase, PgCHT2	Plasmodium gallinaceum	-	-

Organism

Organism	UniProt	Comment	Textmining
Plasmodium gallinaceum	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	presence of PgPM4 in the different life cycle stages, e.g. in asexual blood stage, overview	Plasmodium gallinaceum	-
ookinete	a fertilized zygote capable of moving spontaneously, the enzyme is located at the apical surface	Plasmodium gallinaceum	-
zygote	-	Plasmodium gallinaceum	-

Synonyms

Synonyms	Comment	Organism
PgPM4	-	Plasmodium gallinaceum
plasmepsin 4	-	Plasmodium gallinaceum

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Release 2023.1 (January 2023)