3.4.23.B14: plasmepsin IV
This is an abbreviated version!
For detailed information about plasmepsin IV, go to the full flat file.
Word Map on EC 3.4.23.B14
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3.4.23.B14
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plasmepsins
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plasmodium
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falciparum
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malaria
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vacuole
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hemoglobin
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antimalarial
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cathepsin
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vivax
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ovale
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intraerythrocytic
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medicine
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peptidomimetic
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berghei
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hydroxyethylamine
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allophenylnorstatine
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histo-aspartic
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proplasmepsins
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analysis
- 3.4.23.B14
-
plasmepsins
- plasmodium
- falciparum
- malaria
- vacuole
- hemoglobin
-
antimalarial
- cathepsin
- vivax
- ovale
-
intraerythrocytic
- medicine
-
peptidomimetic
- berghei
-
hydroxyethylamine
-
allophenylnorstatine
-
histo-aspartic
-
proplasmepsins
- analysis
Reaction
cleavage of hemoglobin. In the S3 and S2 subsites, the plasmepsin 4 orthologs all prefer hydrophobic amino acid residues, Phe or Ile, but reject charged residues such as Lys or Asp. In S2' and S3' subsites these plasmepsins tolerate both hydrophobic and hydrophilic residues =
Synonyms
A01.059, PfPM4, PgPM4, plasmepsin 4, Plm IV, PM IV, PM-IV, PM4, PMIV, PmPM4, PoPM4, pPM IV, proplasmepsin IV, PSM4, PvPM4
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Posttranslational Modification
Posttranslational Modification on EC 3.4.23.B14 - plasmepsin IV
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proteolytic modification
incubation of the 44000 Da proplasmepsin IV at pH 4.7 results in its conversion to a protein of 38000 Da. Autoactivation site in proplasmepsin IV -KESFKF-/-F-/-KSGYAQ-
proteolytic modification
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processing of plasmepsin II and plasmepsin IV occurs via an intra- and inter-molecular autocatalytic event as well as via a transcatalytic event between them
proteolytic modification
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maturation of PSM4 is efficient after 5 min at pH 4.5 and 37°C, PSM4 is partly cleaved after Phe109, Phe110, or Phe81 leading to proteins of 38218 Da, 38071 Da, and 41508 Da, respectively, cleavage is not terminated after 7 h
proteolytic modification
processing of PM4 into a mature enzyme occurrs through autocatalytic activity under acidic conditions in a pepstatin A-sensitive manner, in which process a portion of prodomain is essential for correct folding. Cysteine proteases vivapain-2 and vivapain-3 mediate the processing of PvPM4 into a mature enzyme