3.4.23.B14: plasmepsin IV
This is an abbreviated version!
For detailed information about plasmepsin IV, go to the full flat file.
Word Map on EC 3.4.23.B14
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3.4.23.B14
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plasmepsins
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plasmodium
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falciparum
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malaria
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vacuole
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hemoglobin
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antimalarial
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cathepsin
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vivax
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ovale
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intraerythrocytic
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medicine
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peptidomimetic
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berghei
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hydroxyethylamine
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allophenylnorstatine
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histo-aspartic
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proplasmepsins
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analysis
- 3.4.23.B14
-
plasmepsins
- plasmodium
- falciparum
- malaria
- vacuole
- hemoglobin
-
antimalarial
- cathepsin
- vivax
- ovale
-
intraerythrocytic
- medicine
-
peptidomimetic
- berghei
-
hydroxyethylamine
-
allophenylnorstatine
-
histo-aspartic
-
proplasmepsins
- analysis
Reaction
cleavage of hemoglobin. In the S3 and S2 subsites, the plasmepsin 4 orthologs all prefer hydrophobic amino acid residues, Phe or Ile, but reject charged residues such as Lys or Asp. In S2' and S3' subsites these plasmepsins tolerate both hydrophobic and hydrophilic residues =
Synonyms
A01.059, PfPM4, PgPM4, plasmepsin 4, Plm IV, PM IV, PM-IV, PM4, PMIV, PmPM4, PoPM4, pPM IV, proplasmepsin IV, PSM4, PvPM4
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Natural Substrates Products on EC 3.4.23.B14 - plasmepsin IV
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REACTION DIAGRAM
haemoglobin + H2O
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human haemoglobin. The enzyme may play a crucial role in the critical process which yields nutrients from parasite growth, the enzyme may have the potential to initiate the vacuolar haemoglobin digestion pathway
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since plasmepsin IV clearly can cleave within the -Ser-(Phe/Leu)-Lys-Phe-Phe-Lys-(Ser/Thr)-Gly- sequence it may be possible that plasmepsin IV initiates cleavage of the proplasmepsin I precursor
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additional information
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since plasmepsin IV clearly can cleave within the -Ser-(Phe/Leu)-Lys-Phe-Phe-Lys-(Ser/Thr)-Gly- sequence it may be possible that plasmepsin IV initiates cleavage of the proplasmepsin I precursor
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additional information
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the four plasmepsins have overlapping roles in the hemoglobin degradation pathway
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