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3.4.23.B14: plasmepsin IV

This is an abbreviated version!
For detailed information about plasmepsin IV, go to the full flat file.

Word Map on EC 3.4.23.B14

Reaction

cleavage of hemoglobin. In the S3 and S2 subsites, the plasmepsin 4 orthologs all prefer hydrophobic amino acid residues, Phe or Ile, but reject charged residues such as Lys or Asp. In S2' and S3' subsites these plasmepsins tolerate both hydrophobic and hydrophilic residues =

Synonyms

A01.059, PfPM4, PgPM4, plasmepsin 4, Plm IV, PM IV, PM-IV, PM4, PMIV, PmPM4, PoPM4, pPM IV, proplasmepsin IV, PSM4, PvPM4

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B14 plasmepsin IV

Inhibitors

Inhibitors on EC 3.4.23.B14 - plasmepsin IV

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1R,2R,3R,4R)-1,4-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-1,4-bis[5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl]butane-2,3-diol
-
-
(1R,2R,3R,4S)-3-[(4-butylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-3-[(4-heptylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-3-[(4-hexylphenyl)sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-3-[[4-(2-cyclobutylethyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-3-[[4-(2-cyclopentylethyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-3-[[4-(3-cyclohexylpropyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-3-[[4-(3-cyclopentylpropyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-3-[[4-(3-ethoxypropyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-3-[[4-(4,4-dimethylpentyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-3-[[4-(4-fluorobutyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-3-[[4-(4-methoxybutyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-3-[[4-(6-fluorohexyl)phenyl]sulfonyl]-N-(naphthalen-2-ylmethyl)-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[[4-(2-propoxyethyl)phenyl]sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S)-N-(naphthalen-2-ylmethyl)-3-[[4-(pentyloxy)phenyl]sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S,5R)-5-[(cyclobutylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S,5R)-5-[(cyclopentylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S,6R)-6-[(cyclobutylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3R,4S,6R)-6-[(cyclopentylamino)methyl]-N-(naphthalen-2-ylmethyl)-3-[(4-pentylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptan-2-amine
-
-
(1R,2R,3S,4S)-2,3-bis(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane
-
-
(1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
-
-
(1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-(naphthalen-2-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
-
-
(1R,4S)-6-[2-(1,3-benzothiazol-2-ylsulfanyl)ethoxy]-7-[2-(naphthalen-1-yl)ethoxy]-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
-
-
(1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
-
-
(1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-(naphthalen-2-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
-
-
(1R,4S)-6-[2-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]ethoxy]-7-[2-(naphthalen-1-yl)ethoxy]-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
-
-
(1R,4S)-6-[3-(1,3-benzothiazol-2-ylsulfanyl)propyl]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
-
-
(1R,4S)-6-[3-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]propyl]-7-(naphthalen-1-ylmethoxy)-1,2,3,4-tetrahydro-1,4-epiminonaphthalene
-
-
(1S)-3,3-difluoro-4,4-dihydroxy-N-(naphthalen-2-ylmethyl)-N-(4-pentylphenyl)cyclohexanecarboxamide
-
-
(1S,2S,3R,4R)-2-([4-[3-(1,3-benzodioxol-5-yl)propyl]benzyl]oxy)-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane
-
-
(1S,2S,3R,4R)-2-[(4-bromobenzyl)oxy]-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]heptane
-
-
(1Z)-(3,4-dimethoxyphenyl)-N'-[[(3,4,5-trichlorophenoxy)acetyl]oxy]ethanimidamide
-
-
(2R,3R,4R)-2-benzyloxy-3,4-dihydroxy-N-[(1S,2R)-2-hydroxyindan-1-yl]-4-[(2R)-3-oxo-1-oxa-4-aza-cyclotridec-2-yl]butyramide
-
-
(2R,3R,4R)-2-benzyloxy-3,4-dihydroxy-N-[(1S,2R)-2-hydroxyindan-1-yl]-4-[(2R,11E)-3-oxo-1-oxa-4-aza-cyclo-tridec-11-en-2-yl]butyramide
-
-
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-(1,3-benzodioxol-5-yl)prop-2-en-1-yl]oxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6-oxo-6-[2-(3-phenylpropanoyl)hydrazino]hexanamide
-
-
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-(5-methyl-1,3,4-oxadiazol-2-yl)pentanamide
-
-
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-[5-(2-phenylethyl)-1,3,4-oxadiazol-2-yl]pentanamide
-
-
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6-oxo-6-[2-(3-phenylpropanoyl)hydrazino]hexanamide
-
-
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-5-[5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
-
-
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-6-[2-[(4-tert-butylphenyl)carbonyl]hydrazino]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6-oxohexanamide
-
-
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-N'1,N'6-bis[(4-tert-butylphenyl)carbonyl]-3,4-dihydroxyhexanedihydrazide
-
-
(2R,3R,4R,5R)-5-(5-benzyl-1,3,4-oxadiazol-2-yl)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
-
-
(2R,3R,4R,5R)-5-benzyloxy-3,4-dihydroxy-6-oxo-1-oxa-7-aza-cyclohexadec-2-carboxylic acid [(1S,2R)-2-hydroxyindan-1-yl]-amide
-
-
(2R,3R,4R,5R,14E)-5-benzyloxy-3,4-dihydroxy-6-oxo-1-oxa-7-aza-cyclohexadec-14-ene-2-carboxylic acid [(1S,2R)-2-hydroxyindan-1-yl]-amide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-3-hydroxy-4-(4-methylpiperazin-1-yl)-1-phenylbutan-2-yl]-3-methylbutanamide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-3-hydroxy-4-(4-methylpiperazin-1-yl)-1-phenylbutan-2-yl]-3-methylpentanamide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-3-hydroxy-4-(4-methylpiperazin-1-yl)-1-phenylbutan-2-yl]-3-phenylpropanamide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-3-hydroxy-4-(4-methylpiperazin-1-yl)-1-phenylbutan-2-yl]-4-methylpentanamide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-4-(4-ethylpiperazin-1-yl)-3-hydroxy-1-phenylbutan-2-yl]-3-methylbutanamide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-4-(4-ethylpiperazin-1-yl)-3-hydroxy-1-phenylbutan-2-yl]-3-methylpentanamide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-4-(4-ethylpiperazin-1-yl)-3-hydroxy-1-phenylbutan-2-yl]-3-phenylpropanamide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-4-(4-ethylpiperazin-1-yl)-3-hydroxy-1-phenylbutan-2-yl]-4-methylpentanamide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-4-[4-(4-fluorobenzyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]-3-methylbutanamide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-4-[4-(4-fluorobenzyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]-3-methylpentanamide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-4-[4-(4-fluorobenzyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]-3-phenylpropanamide
-
-
(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[(2R,3S)-4-[4-(4-fluorobenzyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]-4-methylpentanamide
-
-
(2S)-N-[(2R,3S)-4-(1,4'-bipiperidin-1'-yl)-3-hydroxy-1-phenylbutan-2-yl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide
-
-
(2S)-N-[(2R,3S)-4-[4-(4-bromobenzyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylbutanamide
-
-
(2S)-N-[(2R,3S)-4-[4-(4-bromobenzyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylpentanamide
-
-
(2S)-N-[(2R,3S)-4-[4-(4-bromobenzyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide
-
-
(2S)-N-[(2R,3S)-4-[4-(4-bromobenzyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanamide
-
-
(2S,2'S)-N,N'-[piperazine-1,4-diylbis[(2R,3S)-3-hydroxy-1-phenylbutane-4,2-diyl]]bis[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylbutanamide]
-
-
(2S,2'S)-N,N'-[piperazine-1,4-diylbis[(2R,3S)-3-hydroxy-1-phenylbutane-4,2-diyl]]bis[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylpentanamide]
-
-
(2S,2'S)-N,N'-[piperazine-1,4-diylbis[(2R,3S)-3-hydroxy-1-phenylbutane-4,2-diyl]]bis[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanamide]
-
-
(2S,2'S)-N,N'-[piperazine-1,4-diylbis[(2R,3S)-3-hydroxy-1-phenylbutane-4,2-diyl]]bis[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanamide]
-
-
(2S,5S,14S,17S,18S)-N-(2-amino-2-oxoethyl)-17-benzyl-18-hydroxy-14-[[N-(3-methylbutanoyl)-L-valyl]amino]-2-(1-methylethyl)-3,8,15,20-tetraoxo-1,4,9,16-tetraazacycloicosane-5-carboxamide
-
-
(3S,4S)-N-butyl-3-hydroxy-6-methyl-4-([N-[(naphthalen-2-yloxy)acetyl]isoleucyl]amino)heptanamide
(3S,4S)-pyrrolidine-3,4-diyl bis(3,3-dimethylbutanoate)
-
-
(3S,4S)-pyrrolidine-3,4-diyl bis(3-methylbutanoate)
-
-
(3S,4S)-pyrrolidine-3,4-diyl bis(naphthalen-1-ylacetate)
-
-
(3S,4S)-pyrrolidine-3,4-diyl bis(naphthalen-2-ylacetate)
-
-
(3S,4S)-pyrrolidine-3,4-diyl bis(phenylacetate)
-
-
(3S,4S)-pyrrolidine-3,4-diyl dibenzoate
-
-
(3S,4S)-pyrrolidine-3,4-diyl dicyclohexanecarboxylate
-
-
(4R)-3-[(2S,3S)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide
-
-
(4R)-3-[(2S,3S)-3-[[(2,6-dimethylphenoxy)acetyl]amino]-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
-
-
(4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-([N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl]amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide
-
-
(4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
-
-
(5-[[(1H-indol-3-ylacetyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-aminobenzoate
-
-
(5-[[(1H-indol-3-ylacetyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-nitrobenzoate
-
-
(5-[[(4-bromobenzoyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-aminobenzoate
-
-
(5-[[(phenylcarbonyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-aminobenzoate
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-
(5-[[(phenylcarbonyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-nitrobenzoate
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-
(6-[[(phenylcarbonyl)oxy]methyl]-2,5,6,7-tetrahydro-1H-azepin-4-yl)methyl 4-aminobenzoate
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-
(6-[[(phenylcarbonyl)oxy]methyl]-2,5,6,7-tetrahydro-1H-azepin-4-yl)methyl 4-nitrobenzoate
-
-
(6S,9S,12R,13S,17S,20R,21S)-13,21-dihydroxy-2,17-dimethyl-6,9-bis(1-methylethyl)-4,7,10,15,18-pentaoxo-12,20-bis(trifluoromethyl)-5,8,11,16,19-pentaazatricosan-23-oic acid
-
-
1,2-diphenylhydrazine
-
-
1-(benzylamino)-3-(3,6-dichloro-9H-carbazol-9-yl)propan-2-ol
-
-
1-[3-chloro-6-(trifluoromethyl)phenanthren-9-yl]-3-(dibutylamino)propan-1-ol
-
i.e. halofantrine
1-[6-chloro-3-(3,4-dichlorophenyl)naphthalen-1-yl]-2-(dibutylamino)ethanol
-
-
2,2-diphenylacetohydrazide
-
-
2,3,4,7-tetrahydro-1H-azepine-3,5-diyldimethanediyl bis(4-aminobenzoate)
-
-
2,3,4,7-tetrahydro-1H-azepine-3,5-diyldimethanediyl bis(4-nitrobenzoate)
-
-
2,3,4,7-tetrahydro-1H-azepine-3,5-diyldimethanediyl dibenzoate
-
-
2,3,4-trifluoro-N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)benzamide
-
-
2-(dihexylamino)-1-(1,2,3,4-tetrahydrophenanthren-9-yl)ethanol
-
-
2-([2-[4-([[(1S,2S,3R,4R)-3-(naphthalen-2-ylmethoxy)-7-azabicyclo[2.2.1]hept-2-yl]oxy]methyl)phenoxy]ethyl]sulfanyl)-1,3-benzothiazole
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-
2-amino-7-(4-butylphenyl)-3-[(5-phenyltetrahydrofuran-2-yl)methyl]quinazolin-4(3H)-one
-
2-amino-7-(4-pentylphenyl)-3-[(5-phenyltetrahydrofuran-2-yl)methyl]quinazolin-4(3H)-one
-
2-amino-7-phenyl-3-(tetrahydrofuran-2-ylmethyl)quinazolin-4(3H)-one
-
2-amino-7-phenyl-3-[(5-phenyltetrahydrofuran-2-yl)methyl]quinazolin-4(3H)-one
-
2-amino-7-[4-(4-phenylbutyl)phenyl]-3-[(5-phenyltetrahydrofuran-2-yl)methyl]quinazolin-4(3H)-one
-
2-methoxybenzohydrazide
-
-
2-nitrobenzohydrazide
-
-
2-[(Z)-1-(4-chlorophenyl)-2-[3-(pyridin-2-yl)isoquinolin-1-yl]ethenyl]hydrazine-1-carboximidothioic acid
-
-
2-[bis(4-methylpentyl)amino]-1-(1,2,3,4-tetrahydrophenanthren-9-yl)ethanol
-
-
3-amino-N-[(4S,6S,7S)-7-[[(2,6-dimethylphenoxy)acetyl]amino]-6-hydroxy-2-methyl-8-phenyloctan-4-yl]benzamide
-
-
4,4'-(hydrazine-1,2-diyl)dipyridine
-
-
4-(1-benzofuran-2-yl)-Na-[(2S,3S)-2-hydroxy-4-phenyl-3-[[N-(pyridin-2-ylcarbonyl)-L-valyl]amino]butyl]-L-phenylalaninamide
-
-
4-amino-N'-(benzyloxy)-N-(2-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N'-[(2,4-dichlorophenyl)methoxy]-N-(2-methylphenyl)-1,2,5-oxadiazole-3-carboximidamide
-
-
4-amino-N-[(4S,6S,7S)-7-[[(2,6-dimethylphenoxy)acetyl]amino]-6-hydroxy-2-methyl-8-phenyloctan-4-yl]benzamide
-
-
4-methyl-N-[2-[2-(naphthalen-2-yl)hydrazinyl]phenyl]benzene-1-sulfonamide
-
-
5-[4-([(1S,2R,3R,4R)-3-[(naphthalen-2-ylmethyl)amino]-7-azabicyclo[2.2.1]hept-2-yl]sulfonyl)phenyl]pentan-1-ol
-
-
6-[4-([(1S,2R,3R,4R)-3-[(naphthalen-2-ylmethyl)amino]-7-azabicyclo[2.2.1]hept-2-yl]sulfonyl)phenyl]hex-5-yn-1-ol
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-
6-[4-([(1S,2R,3R,4R)-3-[(naphthalen-2-ylmethyl)amino]-7-azabicyclo[2.2.1]hept-2-yl]sulfonyl)phenyl]hexan-1-ol
-
-
acetyl-Val-Val-Sta-Ala-Sta
-
butanehydrazide
-
-
Chloroquine
-
-
di-tert-butyl [piperazine-1,4-diylbis[(2R,3S)-3-hydroxy-1-phenylbutane-4,2-diyl]]biscarbamate
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-
isobutyl-Val-Val-Sta-Ala-Sta
-
Iva-Val-Val-Sta-Ala-Sta
-
KNI-10333
-
nanomolar inhibition activity
KNI-10743
-
nanomolar inhibition activity
KNI-727
IC50: 0.00074 mM
KPFEL-CH2-NH-AWT
-
-
KPFSL-CH2-NH-LQF
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-
KPLEF-CH2-NH-FRV
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-
KPLEF-CH2-NH-YRV
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-
KPVEF-CH2-NH-RQT
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-
KPYEF-CH2-NH-RQF
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-
L-lysyl-L-prolyl-L-norleucyl-N-[(1S)-1-([[(1S)-1-[[(1S)-4-amino-1-[[(1R)-1-carboxy-2-methylbutyl]carbamoyl]pent-4-en-1-yl]carbamoyl]-3-methylbutyl]amino]methyl)pentyl]-L-serinamide
-
-
L-lysyl-L-prolyl-L-phenylalanyl-N-[(1S)-1-benzyl-2-[[(1S)-1-benzyl-2-[[(1S)-2-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-1-(hydroxymethyl)-2-oxoethyl]amino]-2-oxoethyl]amino]ethyl]-L-norleucinamide
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-
Lac-Val-Sta-Ala-Sta
-
Lys-Pro-Ile-Glu-Phe-Phe-Ala-Leu
Lys-Pro-Ile-Ile-Phe-Phe-Arg-Leu
Lys-Pro-Ile-Nle-Phe-Phe-Arg-Leu
Lys-Pro-norleucine-Ser-norleucine-CH2-NH-Leu-Gln-Ile
-
-
Lys-Pro-Phe-Nle-Phe-Phe-Ser-Arg
Lys-Pro-Phe-Nle-Phe-Phe-Ser-Ser
methyl [4'-([[1-(1H-imidazol-2-ylmethyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)biphenyl-4-yl]acetate
-
-
N',N''-[1,10-phenanthroline-2,9-diyldi(E)methylylidene]bis[N-(2-methylphenyl)pyridine-2-carbohydrazonamide]
-
-
N'-(3,4-dimethylacridin-9-yl)-2-hydroxybenzohydrazide
-
-
N'-(3,4-dimethylacridin-9-yl)-3-methylbenzohydrazide
-
-
N'-(4-chlorophenyl)-N'-(2-[[(3-chlorophenyl)carbamoyl]amino]phenyl)urea
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-
N'1-[(E)-(2,3-dihydroxyphenyl)methylidene]-N'3-[(Z)-(2,3-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide
-
N,N'-(3S,4S)-pyrrolidine-3,4-diylbis(N-benzyl-2-phenylacetamide)
-
-
N-(3,4-dichlorophenyl)-2-[(4,6-dimethylpyrimidin-2-yl)amino]-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole-1-carboxamide
-
-
N-(cyclopentylcarbamothioyl)-4-ethoxy-3-nitrobenzamide
-
-
N-([5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl]methyl)-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
-
-
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucine
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)-1-benzothiophene-2-carboxamide
-
-
N-([[1-(3-methylbutyl)piperidin-4-yl](4-pentylbenzoyl)amino]methyl)pyridine-3-carboxamide
-
-
N-acetyl-L-Leu-L-Leu-L-norleucinal
-
-
N-acetyl-Leu-Leu-Met-CHO
-
calpaicin inhibitor II
N-acetyl-Leu-Leu-norleucinal
-
calpaicin inhibitor I
N-benzyl-2-bromo-N-[[4-([[2-(2,4-dichlorophenyl)ethyl](3-phenylpropyl)amino]methyl)pyrrolidin-3-yl]methyl]-4,5-dimethoxybenzamide
-
-
N-benzyl-2-bromo-N-[[4-([[2-(2,4-dichlorophenyl)ethyl][2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]amino]methyl)pyrrolidin-3-yl]methyl]-4,5-dimethoxybenzamide
-
-
N-benzyl-2-bromo-N-[[4-([[3-(2,4-dichlorophenyl)propyl](3-phenylpropyl)amino]methyl)pyrrolidin-3-yl]methyl]-4,5-dimethoxybenzamide
-
-
N-benzyl-2-bromo-N-[[4-([[3-(2,4-dichlorophenyl)propyl][2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]amino]methyl)pyrrolidin-3-yl]methyl]-4,5-dimethoxybenzamide
-
-
N-[(1R)-1-[[(1S,2S)-4-[[(1S)-5-amino-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)pentyl]amino]-1-benzyl-2-hydroxy-4-oxobutyl]carbamoyl]-2-methylpropyl]pyridine-2-carboxamide
N-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(cyclohexa-1,3-dien-1-yloxy)acetyl]-L-valinamide
-
-
N-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(isoquinolin-5-yloxy)acetyl]-L-valinamide
-
-
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-([4-[4-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)phenoxy]phenyl]carbonyl)isoleucinamide
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-[[4-(4-[[(1R)-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)-3-methylbutyl]carbamoyl]phenoxy)phenyl]carbonyl]isoleucinamide
N-[(3-ethyl-1,2-oxazol-5-yl)methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
-
-
N-[(4-[2-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-2-oxoethyl]phenyl)acetyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-alanyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucine
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-alaninamide
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
N-[(E)-[(2,4-dimethylphenyl)amino][(4-oxo-1,4,5,6,7,8-hexahydroquinolin-2-yl)amino]methylidene]benzamide
-
-
N-[1-(3-methylbutyl)piperidin-4-yl]-5-pentyl-N-[[4'-(piperidin-1-ylcarbonyl)biphenyl-4-yl]methyl]pyridine-2-carboxamide
-
-
N-[1-(3-methylbutyl)piperidin-4-yl]-N-(2-[4-[methyl(2-methylquinolin-4-yl)amino]phenyl]ethyl)-4-pentylbenzamide
-
-
N-[1-(3-methylbutyl)piperidin-4-yl]-N-[[methyl(pyridin-3-yl)amino]methyl]-4-pentylbenzamide
-
-
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
-
-
N-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-4-oxobutanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
N-[4-[([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)oxy]butanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
N-[[(1S)-3,3-difluoro-4,4-dihydroxycyclohexyl]methyl]-N-(4-pentylphenyl)naphthalene-2-carboxamide
-
-
N-[[5-(2,5-dichlorophenyl)furan-2-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
-
-
N-[[5-(3,4-dichlorophenyl)furan-2-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
-
-
N-[[5-(3,4-dimethoxybenzyl)-1,2,4-oxadiazol-3-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
-
-
N-[[5-(4-chlorophenyl)-1,2-oxazol-3-yl]methyl]-N-[1-(3-methylbutyl)piperidin-4-yl]-4-pentylbenzamide
-
-
N1-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(isoquinolin-5-yloxy)acetyl]-L-aspartamide
-
-
N2-(3-bromophenyl)-N-[4-[(phenylsulfanyl)methyl]phenyl]-N2-(phenylsulfonyl)glycinamide
-
-
pepstatin
pepstatin A
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-L-lysinate
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N6-(tert-butoxycarbonyl)-L-lysinate
ritonavir
-
IC50: 1800 nM
Ro 40-4388
-
-
Ro40-4388
saquinavir
-
IC50: 375 nM
tert-butyl [(1S)-1-[[(3S,7S,10S,19S)-19-[(2-amino-2-oxoethyl)carbamoyl]-7-benzyl-6-hydroxy-3-(1-methylethyl)-2,9,16-trioxo-1,4,8,15-tetraazacyclononadecan-10-yl]carbamoyl]-2-methylpropyl]carbamate
tert-butyl [(2R,3S)-3-hydroxy-4-(4-methylpiperazin-1-yl)-1-phenylbutan-2-yl]carbamate
-
-
tert-butyl [(2R,3S)-4-(1,4'-bipiperidin-1'-yl)-3-hydroxy-1-phenylbutan-2-yl]carbamate
-
-
tert-butyl [(2R,3S)-4-(4-ethylpiperazin-1-yl)-3-hydroxy-1-phenylbutan-2-yl]carbamate
-
-
tert-butyl [(2R,3S)-4-[4-(4-bromobenzyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
-
-
tert-butyl [(2R,3S)-4-[4-(4-fluorobenzyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
-
-
[5-([[(4-bromophenyl)carbonyl]oxy]methyl)-2,3,4,7-tetrahydro-1H-azepin-3-yl]methyl 4-aminobenzoate
-
-
[5-[(benzoyloxy)methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl]methyl 4-aminobenzoate
-
-
[6-([[(4-aminophenyl)carbonyl]oxy]methyl)-2,5,6,7-tetrahydro-1H-azepin-4-yl]methyl naphthalene-1-carboxylate
-
-
[6-([[(4-nitrophenyl)carbonyl]oxy]methyl)-2,5,6,7-tetrahydro-1H-azepin-4-yl]methyl 4-bromobenzoate
-
-
[6-([[(4-nitrophenyl)carbonyl]oxy]methyl)-2,5,6,7-tetrahydro-1H-azepin-4-yl]methyl naphthalene-1-carboxylate
-
-
additional information
-