Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.23.B14: plasmepsin IV

This is an abbreviated version!
For detailed information about plasmepsin IV, go to the full flat file.

Word Map on EC 3.4.23.B14

Reaction

cleavage of hemoglobin. In the S3 and S2 subsites, the plasmepsin 4 orthologs all prefer hydrophobic amino acid residues, Phe or Ile, but reject charged residues such as Lys or Asp. In S2' and S3' subsites these plasmepsins tolerate both hydrophobic and hydrophilic residues =

Synonyms

A01.059, PfPM4, PgPM4, plasmepsin 4, Plm IV, PM IV, PM-IV, PM4, PMIV, PmPM4, PoPM4, pPM IV, proplasmepsin IV, PSM4, PvPM4

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B14 plasmepsin IV

KI Value

KI Value on EC 3.4.23.B14 - plasmepsin IV

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000035
(1R,2R,3R,4R)-1,4-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-1,4-bis[5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl]butane-2,3-diol
-
-
0.0002
(2R,3R,4R)-2-benzyloxy-3,4-dihydroxy-N-[(1S,2R)-2-hydroxyindan-1-yl]-4-[(2R)-3-oxo-1-oxa-4-aza-cyclotridec-2-yl]butyramide
-
-
0.0068
(2R,3R,4R)-2-benzyloxy-3,4-dihydroxy-N-[(1S,2R)-2-hydroxyindan-1-yl]-4-[(2R,11E)-3-oxo-1-oxa-4-aza-cyclo-tridec-11-en-2-yl]butyramide
-
-
0.000397
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-(1,3-benzodioxol-5-yl)prop-2-en-1-yl]oxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6-oxo-6-[2-(3-phenylpropanoyl)hydrazino]hexanamide
-
-
0.01
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-(5-methyl-1,3,4-oxadiazol-2-yl)pentanamide
-
-
0.012
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-[5-(2-phenylethyl)-1,3,4-oxadiazol-2-yl]pentanamide
-
-
0.002
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6-oxo-6-[2-(3-phenylpropanoyl)hydrazino]hexanamide
-
-
0.0012
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-5-[5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
-
-
0.014
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-6-[2-[(4-tert-butylphenyl)carbonyl]hydrazino]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6-oxohexanamide
-
-
0.000478
(2R,3R,4R,5R)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-N'1,N'6-bis[(4-tert-butylphenyl)carbonyl]-3,4-dihydroxyhexanedihydrazide
-
-
0.002
(2R,3R,4R,5R)-5-(5-benzyl-1,3,4-oxadiazol-2-yl)-2,5-bis[[(2E)-3-bromoprop-2-en-1-yl]oxy]-3,4-dihydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
-
-
0.0022
(2R,3R,4R,5R)-5-benzyloxy-3,4-dihydroxy-6-oxo-1-oxa-7-aza-cyclohexadec-2-carboxylic acid [(1S,2R)-2-hydroxyindan-1-yl]-amide
-
-
0.002
(2R,3R,4R,5R,14E)-5-benzyloxy-3,4-dihydroxy-6-oxo-1-oxa-7-aza-cyclohexadec-14-ene-2-carboxylic acid [(1S,2R)-2-hydroxyindan-1-yl]-amide
-
-
0.0274
(2S)-N-[(2R,3S)-4-[4-(4-bromobenzyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylpentanamide
-
at pH 4.5, temperature not specified in the publication
0.0033
(2S,2'S)-N,N'-[piperazine-1,4-diylbis[(2R,3S)-3-hydroxy-1-phenylbutane-4,2-diyl]]bis[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylbutanamide]
-
at pH 4.5, temperature not specified in the publication
0.05
(2S,2'S)-N,N'-[piperazine-1,4-diylbis[(2R,3S)-3-hydroxy-1-phenylbutane-4,2-diyl]]bis[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylpentanamide]
-
at pH 4.5, temperature not specified in the publication
0.05
(2S,2'S)-N,N'-[piperazine-1,4-diylbis[(2R,3S)-3-hydroxy-1-phenylbutane-4,2-diyl]]bis[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-methylpentanamide]
-
at pH 4.5, temperature not specified in the publication
0.00000052
(2S,5S,14S,17S,18S)-N-(2-amino-2-oxoethyl)-17-benzyl-18-hydroxy-14-[[N-(3-methylbutanoyl)-L-valyl]amino]-2-(1-methylethyl)-3,8,15,20-tetraoxo-1,4,9,16-tetraazacycloicosane-5-carboxamide
-
-
0.000017 - 0.0013
(3S,4S)-N-butyl-3-hydroxy-6-methyl-4-([N-[(naphthalen-2-yloxy)acetyl]isoleucyl]amino)heptanamide
0.00011
(4R)-3-[(2S,3S)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide
-
-
0.000015
(4R)-3-[(2S,3S)-3-[[(2,6-dimethylphenoxy)acetyl]amino]-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
-
-
0.00074
(4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-([N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl]amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide
-
-
0.003
(4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
-
-
0.0159
(5-[[(1H-indol-3-ylacetyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-aminobenzoate
-
plasmepsin IV
0.0434
(5-[[(1H-indol-3-ylacetyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-nitrobenzoate
-
plasmepsin IV
0.0072
(5-[[(phenylcarbonyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-aminobenzoate
-
plasmepsin IV
0.0386
(5-[[(phenylcarbonyl)oxy]methyl]-2,3,4,7-tetrahydro-1H-azepin-3-yl)methyl 4-nitrobenzoate
-
plasmepsin IV
0.0099
(6-[[(phenylcarbonyl)oxy]methyl]-2,5,6,7-tetrahydro-1H-azepin-4-yl)methyl 4-aminobenzoate
-
plasmepsin IV
0.029
(6-[[(phenylcarbonyl)oxy]methyl]-2,5,6,7-tetrahydro-1H-azepin-4-yl)methyl 4-nitrobenzoate
-
plasmepsin IV
0.000023
(6S,9S,12R,13S,17S,20R,21S)-13,21-dihydroxy-2,17-dimethyl-6,9-bis(1-methylethyl)-4,7,10,15,18-pentaoxo-12,20-bis(trifluoromethyl)-5,8,11,16,19-pentaazatricosan-23-oic acid
-
-
0.0032
2,3,4,7-tetrahydro-1H-azepine-3,5-diyldimethanediyl bis(4-aminobenzoate)
-
plasmepsin IV
0.0221
2,3,4,7-tetrahydro-1H-azepine-3,5-diyldimethanediyl bis(4-nitrobenzoate)
-
plasmepsin IV
0.211
2,3,4,7-tetrahydro-1H-azepine-3,5-diyldimethanediyl dibenzoate
-
plasmepsin IV
0.000041
4-(1-benzofuran-2-yl)-Na-[(2S,3S)-2-hydroxy-4-phenyl-3-[[N-(pyridin-2-ylcarbonyl)-L-valyl]amino]butyl]-L-phenylalaninamide
-
-
0.0000002
acetyl-Val-Val-Sta-Ala-Sta
pH 4.7
0.0000001
Iva-Val-Va-Sta-Ala-Sta
pH 4.7
0.0081
KPFEL-CH2-NH-AWT
-
at pH 5.0 and 37°C
0.000379
KPFSL-CH2-NH-LQF
-
at pH 5.0 and 37°C
0.0000014
KPLEF-CH2-NH-FRV
-
at pH 5.0 and 37°C
0.00000012
KPLEF-CH2-NH-YRV
-
at pH 5.0 and 37°C
0.000502
KPVEF-CH2-NH-RQT
-
at pH 5.0 and 37°C
0.0039
KPYEF-CH2-NH-RQF
-
at pH 5.0 and 37°C
0.000022
L-lysyl-L-prolyl-L-norleucyl-N-[(1S)-1-([[(1S)-1-[[(1S)-4-amino-1-[[(1R)-1-carboxy-2-methylbutyl]carbamoyl]pent-4-en-1-yl]carbamoyl]-3-methylbutyl]amino]methyl)pentyl]-L-serinamide
-
-
0.000000026
L-lysyl-L-prolyl-L-phenylalanyl-N-[(1S)-1-benzyl-2-[[(1S)-1-benzyl-2-[[(1S)-2-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-1-(hydroxymethyl)-2-oxoethyl]amino]-2-oxoethyl]amino]ethyl]-L-norleucinamide
-
-
0.000025
Lac-Val-Sta-Ala-Sta
pH 4.7
0.00000011 - 0.0000022
Lys-Pro-Ile-Glu-Phe-Phe-Ala-Leu
0.00000053 - 0.0000058
Lys-Pro-Ile-Ile-Phe-Phe-Arg-Leu
0.00000006 - 0.00000041
Lys-Pro-Ile-Nle-Phe-Phe-Arg-Leu
0.000375
Lys-Pro-norleucine-Ser-norleucine-CH2-NH-Leu-Gln-Ile
-
at pH 5.0 and 37°C
0.00000014 - 0.0000006
Lys-Pro-Phe-Nle-Phe-Phe-Ser-Arg
0.000000026 - 0.00000071
Lys-Pro-Phe-Nle-Phe-Phe-Ser-Ser
0.00005
N'1-[(E)-(2,3-dihydroxyphenyl)methylidene]-N'3-[(Z)-(2,3-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide
pH 4.7
0.0000014 - 0.00026
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucine
0.0000006 - 0.000021
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
0.000002 - 0.00003
N-[(1R)-1-[[(1S,2S)-4-[[(1S)-5-amino-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)pentyl]amino]-1-benzyl-2-hydroxy-4-oxobutyl]carbamoyl]-2-methylpropyl]pyridine-2-carboxamide
0.00016
N-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(cyclohexa-1,3-dien-1-yloxy)acetyl]-L-valinamide
-
-
0.000025 - 0.003
N-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(isoquinolin-5-yloxy)acetyl]-L-valinamide
0.0000007 - 0.000058
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-([4-[4-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)phenoxy]phenyl]carbonyl)isoleucinamide
0.0000003 - 0.00025
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-[[4-(4-[[(1R)-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)-3-methylbutyl]carbamoyl]phenoxy)phenyl]carbonyl]isoleucinamide
0.0000005 - 0.000038
N-[(4-[2-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-2-oxoethyl]phenyl)acetyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
0.00000009 - 0.000017
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-alanyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
0.0000045 - 0.000044
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucine
0.00000024 - 0.0000025
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-alaninamide
0.0000005 - 0.00001
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
0.000707
N-[4-(1,3-benzodioxol-5-yl)benzyl]-N-[2-(dibutylamino)ethyl]-4-pentylbenzamide
-
-
0.0000021 - 0.00016
N-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-4-oxobutanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
0.00000014 - 0.000006
N-[4-[([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)oxy]butanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide
0.0071
N1-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(isoquinolin-5-yloxy)acetyl]-L-aspartamide
-
-
0.000000015 - 0.0000023
pepstatin A
0.0000015 - 0.000087
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-L-lysinate
0.0000014 - 0.000019
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N6-(tert-butoxycarbonyl)-L-lysinate
0.00001
Ro 40-4388
-
-
0.00001 - 0.000135
Ro40-4388
0.000015
Ro40-5576
pH 4.7
0.00000029 - 0.00052
tert-butyl [(1S)-1-[[(3S,7S,10S,19S)-19-[(2-amino-2-oxoethyl)carbamoyl]-7-benzyl-6-hydroxy-3-(1-methylethyl)-2,9,16-trioxo-1,4,8,15-tetraazacyclononadecan-10-yl]carbamoyl]-2-methylpropyl]carbamate
0.0057
[5-([[(4-bromophenyl)carbonyl]oxy]methyl)-2,3,4,7-tetrahydro-1H-azepin-3-yl]methyl 4-aminobenzoate
-
plasmepsin IV
0.0015
[6-([[(4-aminophenyl)carbonyl]oxy]methyl)-2,5,6,7-tetrahydro-1H-azepin-4-yl]methyl naphthalene-1-carboxylate
-
plasmepsin IV
0.0688
[6-([[(4-nitrophenyl)carbonyl]oxy]methyl)-2,5,6,7-tetrahydro-1H-azepin-4-yl]methyl 4-bromobenzoate
-
plasmepsin IV
0.0039
[6-([[(4-nitrophenyl)carbonyl]oxy]methyl)-2,5,6,7-tetrahydro-1H-azepin-4-yl]methyl naphthalene-1-carboxylate
-
plasmepsin IV
additional information
additional information
-