3.4.23.B14: plasmepsin IV

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For detailed information about plasmepsin IV, go to the full flat file.

Reaction

cleavage of hemoglobin. In the S3 and S2 subsites, the plasmepsin 4 orthologs all prefer hydrophobic amino acid residues, Phe or Ile, but reject charged residues such as Lys or Asp. In S2' and S3' subsites these plasmepsins tolerate both hydrophobic and hydrophilic residues =

Synonyms

A01.059, PfPM4, PgPM4, plasmepsin 4, Plm IV, PM IV, PM-IV, PM4, PMIV, PmPM4, PoPM4, pPM IV, proplasmepsin IV, PSM4, PvPM4

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B14 plasmepsin IV

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Results	in table
4	AA Sequence
6	Application
1	CAS Registry Number
9	Cloned(Commentary)
5	Crystallization (Commentary)
3	General Information
65	IC50 Value
298	Inhibitors
2	kcat/KM [mM/s]
154	Ki Value [mM]
90	KM Value [mM]
21	Localization
2	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
34	Organism
4	pH Optimum
1	pH Range
1	pH Stability
4	Posttranslational Modification
1	Protein Variants
12	Purification (Commentary)
3	Reaction
1	Reaction Type
34	Reference
3	Renatured (Commentary)
3	Source Tissue
108	Substrates and Products (Substrate)
4	Subunits
45	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
90	Turnover Number [1/s]

Sequence

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Sequence on EC 3.4.23.B14 - plasmepsin IV

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTIONThe reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

D4P4R3 pBLAST

D4P4R3_PLAVI

Plasmodium vivax

450

0

51681

TrEMBL

Show Sequence

-

O60989 pBLAST

O60989_PLAVI

Plasmodium vivax

450

0

51667

TrEMBL

Show Sequence

-

O60990 pBLAST

O60990_PLAMA

Plasmodium malariae

451

0

51809

TrEMBL

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other Location (Reliability: 2)

Q8IM16 pBLAST

PLM4_PLAF7

Plasmodium falciparum (isolate 3D7)

449

1

51046

Swiss-Prot

Show Sequence

-

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