3.4.23.B14: plasmepsin IV
This is an abbreviated version!
For detailed information about plasmepsin IV, go to the full flat file.
Reaction
cleavage of hemoglobin. In the S3 and S2 subsites, the plasmepsin 4 orthologs all prefer hydrophobic amino acid residues, Phe or Ile, but reject charged residues such as Lys or Asp. In S2' and S3' subsites these plasmepsins tolerate both hydrophobic and hydrophilic residues
=
Synonyms
A01.059, PfPM4, PgPM4, plasmepsin 4, Plm IV, PM IV, PM-IV, PM4, PMIV, PmPM4, PoPM4, pPM IV, proplasmepsin IV, PSM4, PvPM4
ECTree
KM Value
KM Value on EC 3.4.23.B14 - plasmepsin IV
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0.035
KEFAFF(NO2)ALK
pH 4.7, 37°C
0.02
KEFNFF(NO2)ALK
pH 4.7, 37°C
0.011
KEFVFF(NO2)ALK
pH 4.7, 37°C
0.017 - 0.05
KPAEFF(NO2)RL
0.029 - 0.063
KPDEFF(NO2)RL
0.009 - 0.014
KPFEFF(NO2)RL
0.005 - 0.012
KPIAFF(NO2)RL
0.01 - 0.023
KPIDFF(NO2)RL
0.0116 - 0.028
KPIEFF(NO2)AL
0.008 - 0.0518
KPIEFF(NO2)EL
0.017 - 0.025
KPIEFF(NO2)KL
0.0146 - 0.044
KPIEFF(NO2)RD
0.0165 - 0.034
KPIEFF(NO2)RI
0.0092 - 0.02
KPIEFF(NO2)RL
0.0037 - 0.0296
KPIEFF(NO2)RR
0.0054 - 0.043
KPIEFF(NO2)RS
0.021 - 0.046
KPIEFF(NO2)RV
0.017 - 0.043
KPIEFF(NO2)SL
0.0044 - 0.023
KPIEFF(NO2)VL
0.036
KPIEFZRL
pH 4.7, 37°C
0.0123 - 0.029
KPIKFF(NO2)RL
0.008 - 0.0166
KPILFF(NO2)RL
0.007 - 0.0429
KPKEFF(NO2)RL
0.012 - 0.041
KPSEFF(NO2)RL
0.0038
Lys-Pro-Ile-Gln-Phe-4-nitrophenylalanine-Arg-Leu
-
at pH 5.5 and 37°C
0.0021
Lys-Pro-Ile-Leu-Phe-4-nitrophenylalanine-Arg-Leu
-
at pH 5.5 and 37°C
0.007 - 0.016
Lys-Pro-Ile-Nle-Phe-Phe(NO2)-Arg-Leu
0.017
KPAEFF(NO2)RL
-
37°C, pH 4.4
0.018
KPAEFF(NO2)RL
-
37°C, pH 4.4
0.0205
KPAEFF(NO2)RL
-
37°C, pH 4.4
0.05
KPAEFF(NO2)RL
-
37°C, pH 4.4
0.029
KPDEFF(NO2)RL
-
37°C, pH 4.4
0.038
KPDEFF(NO2)RL
-
37°C, pH 4.4
0.0424
KPDEFF(NO2)RL
-
37°C, pH 4.4
0.063
KPDEFF(NO2)RL
-
37°C, pH 4.4
0.009
KPFEFF(NO2)RL
-
37°C, pH 4.4
0.011
KPFEFF(NO2)RL
-
37°C, pH 4.4
0.0138
KPFEFF(NO2)RL
-
37°C, pH 4.4
0.014
KPFEFF(NO2)RL
-
37°C, pH 4.4
0.005
KPIAFF(NO2)RL
-
37°C, pH 4.4
0.0092
KPIAFF(NO2)RL
-
37°C, pH 4.4
0.01
KPIAFF(NO2)RL
-
37°C, pH 4.4
0.012
KPIAFF(NO2)RL
-
37°C, pH 4.4
0.01
KPIDFF(NO2)RL
-
37°C, pH 4.4
0.011
KPIDFF(NO2)RL
-
37°C, pH 4.4
0.0172
KPIDFF(NO2)RL
-
37°C, pH 4.4
0.023
KPIDFF(NO2)RL
-
37°C, pH 4.4
0.0116
KPIEFF(NO2)AL
-
37°C, pH 4.4
0.016
KPIEFF(NO2)AL
-
37°C, pH 4.4
0.024
KPIEFF(NO2)AL
-
37°C, pH 4.4
0.028
KPIEFF(NO2)AL
-
37°C, pH 4.4
0.008
KPIEFF(NO2)EL
-
37°C, pH 4.4
0.024
KPIEFF(NO2)EL
-
37°C, pH 4.4
0.039
KPIEFF(NO2)EL
-
37°C, pH 4.4
0.0518
KPIEFF(NO2)EL
-
37°C, pH 4.4
0.017
KPIEFF(NO2)KL
-
37°C, pH 4.4
0.0205
KPIEFF(NO2)KL
-
37°C, pH 4.4
0.021
KPIEFF(NO2)KL
-
37°C, pH 4.4
0.025
KPIEFF(NO2)KL
-
37°C, pH 4.4
0.0146
KPIEFF(NO2)RD
-
37°C, pH 4.4
0.025
KPIEFF(NO2)RD
-
37°C, pH 4.4
0.033
KPIEFF(NO2)RD
-
37°C, pH 4.4
0.044
KPIEFF(NO2)RD
-
37°C, pH 4.4
0.0165
KPIEFF(NO2)RI
-
37°C, pH 4.4
0.017
KPIEFF(NO2)RI
-
37°C, pH 4.4
0.0235
KPIEFF(NO2)RI
-
37°C, pH 4.4
0.034
KPIEFF(NO2)RI
-
37°C, pH 4.4
0.0092
KPIEFF(NO2)RL
-
37°C, pH 4.4
0.0121
KPIEFF(NO2)RL
-
37°C, pH 4.4
0.016
KPIEFF(NO2)RL
-
37°C, pH 4.4
0.02
KPIEFF(NO2)RL
-
37°C, pH 4.4
0.0037
KPIEFF(NO2)RR
-
37°C, pH 4.4
0.004
KPIEFF(NO2)RR
-
37°C, pH 4.4
0.013
KPIEFF(NO2)RR
-
37°C, pH 4.4
0.0296
KPIEFF(NO2)RR
-
37°C, pH 4.4
0.0054
KPIEFF(NO2)RS
-
37°C, pH 4.4
0.014
KPIEFF(NO2)RS
-
37°C, pH 4.4
0.0227
KPIEFF(NO2)RS
-
37°C, pH 4.4
0.043
KPIEFF(NO2)RS
-
37°C, pH 4.4
0.021
KPIEFF(NO2)RV
-
37°C, pH 4.4
0.0253
KPIEFF(NO2)RV
-
37°C, pH 4.4
0.036
KPIEFF(NO2)RV
-
37°C, pH 4.4
0.046
KPIEFF(NO2)RV
-
37°C, pH 4.4
0.017
KPIEFF(NO2)SL
-
37°C, pH 4.4
0.0274
KPIEFF(NO2)SL
-
37°C, pH 4.4
0.039
KPIEFF(NO2)SL
-
37°C, pH 4.4
0.043
KPIEFF(NO2)SL
-
37°C, pH 4.4
0.0044
KPIEFF(NO2)VL
-
37°C, pH 4.4
0.008
KPIEFF(NO2)VL
-
37°C, pH 4.4
0.0205
KPIEFF(NO2)VL
-
37°C, pH 4.4
0.023
KPIEFF(NO2)VL
-
37°C, pH 4.4
0.0123
KPIKFF(NO2)RL
-
37°C, pH 4.4
0.013
KPIKFF(NO2)RL
-
37°C, pH 4.4
0.022
KPIKFF(NO2)RL
-
37°C, pH 4.4
0.029
KPIKFF(NO2)RL
-
37°C, pH 4.4
0.008
KPILFF(NO2)RL
-
37°C, pH 4.4
0.011
KPILFF(NO2)RL
-
37°C, pH 4.4
0.013
KPILFF(NO2)RL
-
37°C, pH 4.4
0.0166
KPILFF(NO2)RL
-
37°C, pH 4.4
0.007
KPKEFF(NO2)RL
-
37°C, pH 4.4
0.024
KPKEFF(NO2)RL
-
37°C, pH 4.4
0.031
KPKEFF(NO2)RL
-
37°C, pH 4.4
0.0429
KPKEFF(NO2)RL
-
37°C, pH 4.4
0.012
KPSEFF(NO2)RL
-
37°C, pH 4.4
0.022
KPSEFF(NO2)RL
-
37°C, pH 4.4
0.0399
KPSEFF(NO2)RL
-
37°C, pH 4.4
0.041
KPSEFF(NO2)RL
-
37°C, pH 4.4
0.007
Lys-Pro-Ile-Nle-Phe-Phe(NO2)-Arg-Leu
-
37°C, pH 4.4
0.0096
Lys-Pro-Ile-Nle-Phe-Phe(NO2)-Arg-Leu
-
37°C, pH 4.4
0.011
Lys-Pro-Ile-Nle-Phe-Phe(NO2)-Arg-Leu
-
37°C, pH 4.4
0.016
Lys-Pro-Ile-Nle-Phe-Phe(NO2)-Arg-Leu
-
37°C, pH 4.4
3.4.23.B14 plasmepsin IV
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