3.4.23.B14: plasmepsin IV

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For detailed information about plasmepsin IV, go to the full flat file.

Reaction

cleavage of hemoglobin. In the S3 and S2 subsites, the plasmepsin 4 orthologs all prefer hydrophobic amino acid residues, Phe or Ile, but reject charged residues such as Lys or Asp. In S2' and S3' subsites these plasmepsins tolerate both hydrophobic and hydrophilic residues =

Synonyms

A01.059, PfPM4, PgPM4, plasmepsin 4, Plm IV, PM IV, PM-IV, PM4, PMIV, PmPM4, PoPM4, pPM IV, proplasmepsin IV, PSM4, PvPM4

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B14 plasmepsin IV

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Results	in table
4	AA Sequence
6	Application
1	CAS Registry Number
9	Cloned(Commentary)
5	Crystallization (Commentary)
3	General Information
65	IC50 Value
298	Inhibitors
2	kcat/KM [mM/s]
154	Ki Value [mM]
90	KM Value [mM]
21	Localization
2	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
34	Organism
4	pH Optimum
1	pH Range
1	pH Stability
4	Posttranslational Modification
1	Protein Variants
12	Purification (Commentary)
3	Reaction
1	Reaction Type
34	Reference
3	Renatured (Commentary)
3	Source Tissue
108	Substrates and Products (Substrate)
4	Subunits
45	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
90	Turnover Number [1/s]

General Information

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General Information on EC 3.4.23.B14 - plasmepsin IV

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Plasmodium berghei

-

PM4 deficiency results in significantly less virulence than that for the parental parasite. Enzyme-deficient parasites fail to induce experimental cerebral malaria in susceptible mice, and resistant mice are able to clear infections

707051

physiological function

2 entries

physiological function

Plasmodium berghei

-

the enzyme contributes to hemoglobin digestion

707051

physiological function

Plasmodium falciparum

-

the enzyme is involved in host hemoglobin degradation

708127