3.4.23.B14: plasmepsin IV
This is an abbreviated version!
For detailed information about plasmepsin IV, go to the full flat file.
Word Map on EC 3.4.23.B14
-
3.4.23.B14
-
plasmepsins
-
plasmodium
-
falciparum
-
malaria
-
vacuole
-
hemoglobin
-
antimalarial
-
cathepsin
-
vivax
-
ovale
-
intraerythrocytic
-
medicine
-
peptidomimetic
-
berghei
-
hydroxyethylamine
-
allophenylnorstatine
-
histo-aspartic
-
proplasmepsins
-
analysis
- 3.4.23.B14
-
plasmepsins
- plasmodium
- falciparum
- malaria
- vacuole
- hemoglobin
-
antimalarial
- cathepsin
- vivax
- ovale
-
intraerythrocytic
- medicine
-
peptidomimetic
- berghei
-
hydroxyethylamine
-
allophenylnorstatine
-
histo-aspartic
-
proplasmepsins
- analysis
Reaction
cleavage of hemoglobin. In the S3 and S2 subsites, the plasmepsin 4 orthologs all prefer hydrophobic amino acid residues, Phe or Ile, but reject charged residues such as Lys or Asp. In S2' and S3' subsites these plasmepsins tolerate both hydrophobic and hydrophilic residues =
Synonyms
A01.059, PfPM4, PgPM4, plasmepsin 4, Plm IV, PM IV, PM-IV, PM4, PMIV, PmPM4, PoPM4, pPM IV, proplasmepsin IV, PSM4, PvPM4
ECTree
Advanced search results
General Information
General Information on EC 3.4.23.B14 - plasmepsin IV
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
malfunction
-
PM4 deficiency results in significantly less virulence than that for the parental parasite. Enzyme-deficient parasites fail to induce experimental cerebral malaria in susceptible mice, and resistant mice are able to clear infections
physiological function
physiological function
-
the enzyme is involved in host hemoglobin degradation