3.4.23.B14: plasmepsin IV

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For detailed information about plasmepsin IV, go to the full flat file.

Reaction

cleavage of hemoglobin. In the S3 and S2 subsites, the plasmepsin 4 orthologs all prefer hydrophobic amino acid residues, Phe or Ile, but reject charged residues such as Lys or Asp. In S2' and S3' subsites these plasmepsins tolerate both hydrophobic and hydrophilic residues =

Synonyms

A01.059, PfPM4, PgPM4, plasmepsin 4, Plm IV, PM IV, PM-IV, PM4, PMIV, PmPM4, PoPM4, pPM IV, proplasmepsin IV, PSM4, PvPM4

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B14 plasmepsin IV

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Results	in table
4	AA Sequence
6	Application
1	CAS Registry Number
9	Cloned(Commentary)
5	Crystallization (Commentary)
3	General Information
65	IC50 Value
298	Inhibitors
2	kcat/KM [mM/s]
154	Ki Value [mM]
90	KM Value [mM]
21	Localization
2	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
34	Organism
4	pH Optimum
1	pH Range
1	pH Stability
4	Posttranslational Modification
1	Protein Variants
12	Purification (Commentary)
3	Reaction
1	Reaction Type
34	Reference
3	Renatured (Commentary)
3	Source Tissue
108	Substrates and Products (Substrate)
4	Subunits
45	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
90	Turnover Number [1/s]

Source Tissue

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Source Tissue on EC 3.4.23.B14 - plasmepsin IV

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

ookinete

Plasmodium gallinaceum

-

a fertilized zygote capable of moving spontaneously, the enzyme is located at the apical surface

709159

brenda

zygote

Plasmodium gallinaceum

-

-

709159

brenda

additional information

Plasmodium gallinaceum

-

presence of PgPM4 in the different life cycle stages, e.g. in asexual blood stage, overview

709159

brenda