Literature summary for 3.4.23.B14 extracted from

Andrews, K.T.; Fairlie, D.P.; Madala, P.K.; Ray, J.; Wyatt, D.M.; Hilton, P.M.; Melville, L.A.; Beattie, L.; Gardiner, D.L.; Reid, R.C.; Stoermer, M.J.; Skinner-Adams, T.; Berry, C.; McCarthy, J.S.
Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria (2006), Antimicrob. Agents Chemother., 50, 639-648.

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Inhibitors

Inhibitors	Comment	Organism	Structure
pepstatin	IC50: about 1 nM	Plasmodium falciparum
ritonavir	IC50: 1800 nM	Plasmodium falciparum
saquinavir	IC50: 375 nM	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Synonyms

Synonyms	Comment	Organism
PM-IV	-	Plasmodium falciparum

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000001	-	IC50: about 1 nM	Plasmodium falciparum	pepstatin
0.000375	-	IC50: 375 nM	Plasmodium falciparum	saquinavir
0.0018	-	IC50: 1800 nM	Plasmodium falciparum	ritonavir

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Release 2023.1 (January 2023)