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Reference on EC 3.4.23.B14 - plasmepsin IV

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wyatt, D.M.; Berry, C.
Activity and inhibition of plasmepsin IV, a new aspartic proteinase from the malaria parasite, Plasmodium falciparum
FEBS Lett.
513
159-162
2002
Plasmodium falciparum (Q8IM16), Plasmodium falciparum
Manually annotated by BRENDA team
Dame, J.B.; Yowell, C.A.; Omara-Opyene, L.; Carlton, J.M.; Cooper, R.A.; Li, T.
Plasmepsin 4, the food vacuole aspartic proteinase found in all Plasmodium spp. Infecting man
Mol. Biochem. Parasitol.
130
1-12
2003
Plasmodium falciparum (Q8IM16), Plasmodium falciparum
Manually annotated by BRENDA team
Nezami, A.; Kimura, T.; Hidaka, K.; Kiso, A.; Liu, J.; Kiso, Y.; Goldberg, D.E.; Freire, E.
High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor
Biochemistry
42
8459-8464
2003
Plasmodium falciparum (Q8IM16), Plasmodium falciparum
Manually annotated by BRENDA team
Clemente, J.C.; Govindasamy, L.; Madabushi, A.; Fisher, S.Z.; Moose, R.E.; Yowell, C.A.; Hidaka, K.; Kimura, T.; Hayashi, Y.; Kiso, Y.; Agbandje-McKenna, M.; Dame, J.B.; Dunn, B.M.; McKenna, R.
Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor
Acta Crystallogr. Sect. D
D62
246-252
2006
Plasmodium malariae
Manually annotated by BRENDA team
Madabushi, A.; Chakraborty, S.; Fisher, S.Z.; Clemente, J.C.; Yowell, C.; Agbandje-McKenna, M.; Dame, J.B.; Dunn, B.M.; McKenna, R.
Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae
Acta Crystallogr. Sect. F
61
228-231
2005
Plasmodium falciparum
Manually annotated by BRENDA team
Andrews, K.T.; Fairlie, D.P.; Madala, P.K.; Ray, J.; Wyatt, D.M.; Hilton, P.M.; Melville, L.A.; Beattie, L.; Gardiner, D.L.; Reid, R.C.; Stoermer, M.J.; Skinner-Adams, T.; Berry, C.; McCarthy, J.S.
Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria
Antimicrob. Agents Chemother.
50
639-648
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Gutierrez-de-Teran, H.; Nervall, M.; Ersmark, K.; Liu, P.; Janka, L.K.; Dunn, B.; Hallberg, A.; Aqvist, J.
Inhibitor binding to the plasmepsin IV aspartic protease from Plasmodium falciparum
Biochemistry
45
10529-10541
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Ersmark, K.; Nervall, M.; Gutierrez-de-Teran, H.; Hamelink, E.; Janka, L.K.; Clemente, J.C.; Dunn, B.M.; Gogoll, A.; Samuelsson, B.; Qvist, J.; Hallberg, A.
Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV
Bioorg. Med. Chem.
14
2197-2208
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Kim, Y.M.; Lee, M.H.; Piao, T.G.; Lee, J.W.; Kim, J.H.; Lee, S.; Choi, K.M.; Jiang, J.H.; Kim, T.U.; Park, H.
Prodomain processing of recombinant plasmepsin II and IV, the aspartic proteases of Plasmodium falciparum, is auto- and trans-catalytic
J. Biochem.
139
189-195
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Liu, J.; Gluzman, I.Y.; Drew, M.E.; Goldberg, D.E.
The role of Plasmodium falciparum food vacuole plasmepsins
J. Biol. Chem.
280
1432-1437
2005
Plasmodium falciparum
Manually annotated by BRENDA team
Ersmark, K.; Samuelsson, B.; Hallberg, A.
Plasmepsins as potential targets for new antimalarial therapy
Med. Res. Rev.
26
626-666
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Li, T.; Yowell, C.A.; Beyer, B.B.; Hung, S.H.; Westling, J.; Lam, M.T.; Dunn, B.M.; Dame, J.B.
Recombinant expression and enzymatic subsite characterization of plasmepsin 4 from the four Plasmodium species infecting man
Mol. Biochem. Parasitol.
135
101-109
2004
Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale
Manually annotated by BRENDA team
Luksch, T.; Chan, N.S.; Brass, S.; Sotriffer, C.A.; Klebe, G.; Diederich, W.E.
Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors
ChemMedChem
3
1323-1336
2008
Plasmodium falciparum
Manually annotated by BRENDA team
Janka, L.; Clemente, J.; Vaiana, N.; Sparatore, A.; Romeo, S.; Dunn, B.M.
Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors
Protein Pept. Lett.
15
868-873
2008
Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale
Manually annotated by BRENDA team
Spaccapelo, R.; Janse, C.J.; Caterbi, S.; Franke-Fayard, B.; Bonilla, J.A.; Syphard, L.M.; Di Cristina, M.; Dottorini, T.; Savarino, A.; Cassone, A.; Bistoni, F.; Waters, A.P.; Dame, J.B.; Crisanti, A.
Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria
Am. J. Pathol.
176
205-217
2010
Plasmodium berghei
Manually annotated by BRENDA team
Luksch, T.; Blum, A.; Klee, N.; Diederich, W.E.; Sotriffer, C.A.; Klebe, G.
Pyrrolidine derivatives as plasmepsin inhibitors: binding mode analysis assisted by molecular dynamics simulations of a highly flexible protein
ChemMedChem
5
443-454
2010
Plasmodium falciparum
Manually annotated by BRENDA team
Marcoux, J.; Thierry, E.; Vives, C.; Signor, L.; Fieschi, F.; Forest, E.
Investigating alternative acidic proteases for H/D exchange coupled to mass spectrometry: plasmepsin 2 but not plasmepsin 4 is active under quenching conditions
J. Am. Soc. Mass Spectrom.
21
76-79
2010
Plasmodium falciparum
Manually annotated by BRENDA team
Li, F.; Patra, K.P.; Yowell, C.A.; Dame, J.B.; Chin, K.; Vinetz, J.M.
Apical surface expression of aspartic protease plasmepsin 4, a potential transmission-blocking target of the Plasmodium ookinete
J. Biol. Chem.
285
8076-8083
2010
Plasmodium gallinaceum
Manually annotated by BRENDA team
Silva, N.; Lameira, J.; Alves, C.
A quantum mechanical/molecular mechanical study of the aspartic protease plasmepsin IV complexed with allophenylnorstatine-based inhibitor
Chem. Phys. Lett.
509
169-174
2011
Plasmodium malariae (O60990)
-
Manually annotated by BRENDA team
Moon, S.U.; Kang, J.M.; Kim, T.S.; Kong, Y.; Sohn, W.M.; Na, B.K.
Plasmodium vivax: collaborative roles for plasmepsin 4 and vivapains in hemoglobin hydrolysis
Exp. Parasitol.
128
127-132
2011
Plasmodium vivax (O60989), Plasmodium vivax
Manually annotated by BRENDA team
Rawat, M.; Vijay, S.; Gupta, Y.; Dixit, R.; Tiwari, P.K.; Sharma, A.
Sequence homology and structural analysis of plasmepsin 4 isolated from Indian Plasmodium vivax isolates
Infect. Genet. Evol.
11
924-933
2011
Plasmodium vivax (D4P4R3), Plasmodium vivax
Manually annotated by BRENDA team
Recacha, R.; Jaudzems, K.; Akopjana, I.; Jirgensons, A.; Tars, K.
Crystal structure of Plasmodium falciparum proplasmepsin IV the plasticity of proplasmepsins
Acta Crystallogr. Sect. F
72
659-666
2016
Plasmodium falciparum (Q8IM16), Plasmodium falciparum
Manually annotated by BRENDA team
Mishra, V.; Rathore, I.; Arekar, A.; Sthanam, L.K.; Xiao, H.; Kiso, Y.; Sen, S.; Patankar, S.; Gustchina, A.; Hidaka, K.; Wlodawer, A.; Yada, R.Y.; Bhaumik, P.
Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights
FEBS J.
285
3077-3096
2018
Plasmodium falciparum
Manually annotated by BRENDA team
Huizing, A.P.; Mondal, M.; Hirsch, A.K.
Fighting malaria structureguided discovery of nonpeptidomimetic plasmepsin inhibitors
J. Med. Chem.
58
5151-5163
2015
Plasmodium falciparum
Manually annotated by BRENDA team
Rasina, D.; Otikovs, M.; Leitans, J.; Recacha, R.; Borysov, O.V.; Kanepe-Lapsa, I.; Domraceva, I.; Pantelejevs, T.; Tars, K.; Blackman, M.J.; Jaudzems, K.; Jirgensons, A.
Fragment-based discovery of 2-aminoquinazolin-4(3H)-ones as novel class nonpeptidomimetic inhibitors of the plasmepsins I, II, and IV
J. Med. Chem.
59
374-387
2016
Plasmodium falciparum (Q8IM16)
Manually annotated by BRENDA team
Singh, A.K.; Rathore, S.; Tang, Y.; Goldfarb, N.E.; Dunn, B.M.; Rajendran, V.; Ghosh, P.C.; Singh, N.; Latha, N.; Singh, B.K.; Rawat, M.; Rathi, B.
Hydroxyethylamine based phthalimides as new class of plasmepsin hits design, synthesis and antimalarial evaluation
PLoS ONE
10
e0139347
2015
Plasmodium falciparum
Manually annotated by BRENDA team
Liu, P.; Robbins, A.H.; Marzahn, M.R.; McClung, S.H.; Yowell, C.A.; Stevens, S.M.; Dame, J.B.; Dunn, B.M.
Enzymatic characterization of recombinant food vacuole plasmepsin 4 from the rodent malaria parasite Plasmodium berghei
PLoS ONE
10
e0141758
2015
Plasmodium berghei
Manually annotated by BRENDA team
McGillewie, L.; Soliman, M.E.
Flap flexibility amongst plasmepsins I, II, III, IV, and V Sequence, structural, and molecular dynamics analyses
Proteins
83
1693-1705
2015
Plasmodium falciparum (Q8IM16), Plasmodium falciparum
Manually annotated by BRENDA team