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Literature summary for 3.4.23.B14 extracted from

  • Spaccapelo, R.; Janse, C.J.; Caterbi, S.; Franke-Fayard, B.; Bonilla, J.A.; Syphard, L.M.; Di Cristina, M.; Dottorini, T.; Savarino, A.; Cassone, A.; Bistoni, F.; Waters, A.P.; Dame, J.B.; Crisanti, A.
    Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria (2010), Am. J. Pathol., 176, 205-217.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene pm4 Plasmodium berghei

Protein Variants

Protein Variants Comment Organism
additional information construction of 1092cl4 and 1092cl6, two parasite lines deficient in expressing PM4, by gene disruption, and of mutant lines 688cl2 and 688cl3. PM4 deficiency results in significantly less virulence than that for the parental parasite. Enzyme-deficient parasites fail to induce experimental cerebral malaria in susceptible mice, and resistant mice are able to clear infections. The mutant acts as vaccine, immunity through antibody-mediated parasite clearance in the spleen, virulence-attenuated phenotypes, overview Plasmodium berghei

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Plasmodium berghei 5764
-

Organism

Organism UniProt Comment Textmining
Plasmodium berghei
-
 rodent malaria parasite, wild-type line1037cl1 gene pm4
-

Synonyms

Synonyms Comment Organism
plasmepsin 4
-
 Plasmodium berghei
PM4
-
 Plasmodium berghei

General Information

General Information Comment Organism
malfunction PM4 deficiency results in significantly less virulence than that for the parental parasite. Enzyme-deficient parasites fail to induce experimental cerebral malaria in susceptible mice, and resistant mice are able to clear infections Plasmodium berghei
physiological function the enzyme contributes to hemoglobin digestion Plasmodium berghei