Literature summary for 3.4.23.B14 extracted from

Janka, L.; Clemente, J.; Vaiana, N.; Sparatore, A.; Romeo, S.; Dunn, B.M.
Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors (2008), Protein Pept. Lett., 15, 868-873.

Search for more literature for 3.4.23.B14

Inhibitors

Inhibitors	Comment	Organism
(3S,4S)-N-butyl-3-hydroxy-6-methyl-4-([N-[(naphthalen-2-yloxy)acetyl]isoleucyl]amino)heptanamide	-	Plasmodium falciparum
(3S,4S)-N-butyl-3-hydroxy-6-methyl-4-([N-[(naphthalen-2-yloxy)acetyl]isoleucyl]amino)heptanamide	-	Plasmodium malariae
(3S,4S)-N-butyl-3-hydroxy-6-methyl-4-([N-[(naphthalen-2-yloxy)acetyl]isoleucyl]amino)heptanamide	-	Plasmodium ovale
(3S,4S)-N-butyl-3-hydroxy-6-methyl-4-([N-[(naphthalen-2-yloxy)acetyl]isoleucyl]amino)heptanamide	-	Plasmodium vivax
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucine	-	Plasmodium falciparum
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucine	-	Plasmodium malariae
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucine	-	Plasmodium ovale
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucine	-	Plasmodium vivax
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium falciparum
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium malariae
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium ovale
N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium vivax
N-[(1R)-1-[[(1S,2S)-4-[[(1S)-5-amino-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)pentyl]amino]-1-benzyl-2-hydroxy-4-oxobutyl]carbamoyl]-2-methylpropyl]pyridine-2-carboxamide	-	Plasmodium falciparum
N-[(1R)-1-[[(1S,2S)-4-[[(1S)-5-amino-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)pentyl]amino]-1-benzyl-2-hydroxy-4-oxobutyl]carbamoyl]-2-methylpropyl]pyridine-2-carboxamide	-	Plasmodium malariae
N-[(1R)-1-[[(1S,2S)-4-[[(1S)-5-amino-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)pentyl]amino]-1-benzyl-2-hydroxy-4-oxobutyl]carbamoyl]-2-methylpropyl]pyridine-2-carboxamide	-	Plasmodium ovale
N-[(1R)-1-[[(1S,2S)-4-[[(1S)-5-amino-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)pentyl]amino]-1-benzyl-2-hydroxy-4-oxobutyl]carbamoyl]-2-methylpropyl]pyridine-2-carboxamide	-	Plasmodium vivax
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-([4-[4-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)phenoxy]phenyl]carbonyl)isoleucinamide	-	Plasmodium falciparum
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-([4-[4-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)phenoxy]phenyl]carbonyl)isoleucinamide	-	Plasmodium malariae
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-([4-[4-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)phenoxy]phenyl]carbonyl)isoleucinamide	-	Plasmodium ovale
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-([4-[4-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)phenoxy]phenyl]carbonyl)isoleucinamide	-	Plasmodium vivax
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-[[4-(4-[[(1R)-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)-3-methylbutyl]carbamoyl]phenoxy)phenyl]carbonyl]isoleucinamide	-	Plasmodium falciparum
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-[[4-(4-[[(1R)-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)-3-methylbutyl]carbamoyl]phenoxy)phenyl]carbonyl]isoleucinamide	-	Plasmodium malariae
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-[[4-(4-[[(1R)-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)-3-methylbutyl]carbamoyl]phenoxy)phenyl]carbonyl]isoleucinamide	-	Plasmodium ovale
N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-[[4-(4-[[(1R)-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)-3-methylbutyl]carbamoyl]phenoxy)phenyl]carbonyl]isoleucinamide	-	Plasmodium vivax
N-[(4-[2-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-2-oxoethyl]phenyl)acetyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium falciparum
N-[(4-[2-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-2-oxoethyl]phenyl)acetyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium malariae
N-[(4-[2-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-2-oxoethyl]phenyl)acetyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium ovale
N-[(4-[2-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-2-oxoethyl]phenyl)acetyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium vivax
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-alanyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium falciparum
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-alanyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium malariae
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-alanyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium ovale
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-alanyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium vivax
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucine	-	Plasmodium falciparum
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucine	-	Plasmodium malariae
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucine	-	Plasmodium ovale
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucine	-	Plasmodium vivax
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-alaninamide	-	Plasmodium falciparum
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-alaninamide	-	Plasmodium malariae
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-alaninamide	-	Plasmodium ovale
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-alaninamide	-	Plasmodium vivax
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium falciparum
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium malariae
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium ovale
N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium vivax
N-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-4-oxobutanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium falciparum
N-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-4-oxobutanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium malariae
N-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-4-oxobutanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium ovale
N-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-4-oxobutanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium vivax
N-[4-[([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)oxy]butanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium falciparum
N-[4-[([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)oxy]butanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium malariae
N-[4-[([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)oxy]butanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium ovale
N-[4-[([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)oxy]butanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium vivax
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-L-lysinate	-	Plasmodium falciparum
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-L-lysinate	-	Plasmodium malariae
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-L-lysinate	-	Plasmodium ovale
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-L-lysinate	-	Plasmodium vivax
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N6-(tert-butoxycarbonyl)-L-lysinate	-	Plasmodium falciparum
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N6-(tert-butoxycarbonyl)-L-lysinate	-	Plasmodium malariae
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N6-(tert-butoxycarbonyl)-L-lysinate	-	Plasmodium ovale
propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N6-(tert-butoxycarbonyl)-L-lysinate	-	Plasmodium vivax

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
vacuole	-	Plasmodium falciparum	5773	-
vacuole	-	Plasmodium vivax	5773	-
vacuole	-	Plasmodium malariae	5773	-
vacuole	-	Plasmodium ovale	5773	-

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-
Plasmodium malariae	-	-	-
Plasmodium ovale	-	-	-
Plasmodium vivax	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Plasmodium falciparum
-	Plasmodium vivax
-	Plasmodium malariae
-	Plasmodium ovale

Synonyms

Synonyms	Comment	Organism
PfPM4	-	Plasmodium falciparum
plasmepsin 4	-	Plasmodium falciparum
plasmepsin 4	-	Plasmodium vivax
plasmepsin 4	-	Plasmodium malariae
plasmepsin 4	-	Plasmodium ovale
PmPM4	-	Plasmodium malariae
PoPM4	-	Plasmodium ovale
PvPM4	-	Plasmodium vivax

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.00000009	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-alanyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium malariae
0.00000014	-	N-[4-[([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)oxy]butanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium malariae
0.0000002	-	N-[4-[([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)oxy]butanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium vivax
0.00000024	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-alaninamide	37°C, pH 4.4	Plasmodium vivax
0.00000028	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-alanyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium vivax
0.0000003	-	N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-[[4-(4-[[(1R)-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)-3-methylbutyl]carbamoyl]phenoxy)phenyl]carbonyl]isoleucinamide	37°C, pH 4.4	Plasmodium malariae
0.0000004	-	N-[4-[([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)oxy]butanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium ovale
0.0000005	-	N-[(4-[2-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-2-oxoethyl]phenyl)acetyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium malariae
0.0000005	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium falciparum
0.00000051	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-alaninamide	37°C, pH 4.4	Plasmodium falciparum
0.00000051	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-alaninamide	37°C, pH 4.4	Plasmodium malariae
0.0000006	-	N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium malariae
0.0000007	-	N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-([4-[4-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)phenoxy]phenyl]carbonyl)isoleucinamide	37°C, pH 4.4	Plasmodium vivax
0.0000012	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-alanyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium ovale
0.0000012	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium vivax
0.0000012	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium malariae
0.0000014	-	propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N6-(tert-butoxycarbonyl)-L-lysinate	37°C, pH 4.4	Plasmodium malariae
0.0000014	-	N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucine	37°C, pH 4.4	Plasmodium malariae
0.0000015	-	N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium vivax
0.0000015	-	propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-L-lysinate	37°C, pH 4.4	Plasmodium malariae
0.0000017	-	N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium ovale
0.000002	-	N-[(1R)-1-[[(1S,2S)-4-[[(1S)-5-amino-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)pentyl]amino]-1-benzyl-2-hydroxy-4-oxobutyl]carbamoyl]-2-methylpropyl]pyridine-2-carboxamide	37°C, pH 4.4	Plasmodium vivax
0.000002	-	propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N6-(tert-butoxycarbonyl)-L-lysinate	37°C, pH 4.4	Plasmodium ovale
0.0000021	-	N-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-4-oxobutanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium malariae
0.0000022	-	N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-([4-[4-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)phenoxy]phenyl]carbonyl)isoleucinamide	37°C, pH 4.4	Plasmodium malariae
0.0000025	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-alaninamide	37°C, pH 4.4	Plasmodium ovale
0.000003	-	N-[(1R)-1-[[(1S,2S)-4-[[(1S)-5-amino-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)pentyl]amino]-1-benzyl-2-hydroxy-4-oxobutyl]carbamoyl]-2-methylpropyl]pyridine-2-carboxamide	37°C, pH 4.4	Plasmodium ovale
0.000003	-	N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-([4-[4-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)phenoxy]phenyl]carbonyl)isoleucinamide	37°C, pH 4.4	Plasmodium ovale
0.000004	-	propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N6-(tert-butoxycarbonyl)-L-lysinate	37°C, pH 4.4	Plasmodium vivax
0.0000045	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucine	-	Plasmodium malariae
0.0000052	-	N-[(1R)-1-[[(1S,2S)-4-[[(1S)-5-amino-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)pentyl]amino]-1-benzyl-2-hydroxy-4-oxobutyl]carbamoyl]-2-methylpropyl]pyridine-2-carboxamide	37°C, pH 4.4	Plasmodium falciparum
0.000006	-	N-[4-[([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)oxy]butanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	-	Plasmodium falciparum
0.00001	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucine	-	Plasmodium vivax
0.00001	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium ovale
0.000011	-	propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-L-lysinate	37°C, pH 4.4	Plasmodium vivax
0.000014	-	N-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-4-oxobutanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium vivax
0.000015	-	N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-[[4-(4-[[(1R)-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)-3-methylbutyl]carbamoyl]phenoxy)phenyl]carbonyl]isoleucinamide	37°C, pH 4.4	Plasmodium vivax
0.000016	-	N-[(4-[2-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-2-oxoethyl]phenyl)acetyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium vivax
0.000017	-	(3S,4S)-N-butyl-3-hydroxy-6-methyl-4-([N-[(naphthalen-2-yloxy)acetyl]isoleucyl]amino)heptanamide	37°C, pH 4.4	Plasmodium vivax
0.000017	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-alanyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium falciparum
0.000017	-	propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-L-lysinate	37°C, pH 4.4	Plasmodium ovale
0.000019	-	(3S,4S)-N-butyl-3-hydroxy-6-methyl-4-([N-[(naphthalen-2-yloxy)acetyl]isoleucyl]amino)heptanamide	37°C, pH 4.4	Plasmodium malariae
0.000019	-	propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-N6-(tert-butoxycarbonyl)-L-lysinate	37°C, pH 4.4	Plasmodium falciparum
0.000021	-	N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium falciparum
0.000021	-	N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-[[4-(4-[[(1R)-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)-3-methylbutyl]carbamoyl]phenoxy)phenyl]carbonyl]isoleucinamide	37°C, pH 4.4	Plasmodium ovale
0.000029	-	N-[(4-[2-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-2-oxoethyl]phenyl)acetyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium falciparum
0.00003	-	N-[(1R)-1-[[(1S,2S)-4-[[(1S)-5-amino-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)pentyl]amino]-1-benzyl-2-hydroxy-4-oxobutyl]carbamoyl]-2-methylpropyl]pyridine-2-carboxamide	37°C, pH 4.4	Plasmodium malariae
0.000038	-	N-[(4-[2-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-2-oxoethyl]phenyl)acetyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium ovale
0.000039	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucine	-	Plasmodium falciparum
0.000044	-	N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucine	-	Plasmodium ovale
0.000047	-	N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucine	37°C, pH 4.4	Plasmodium vivax
0.000058	-	N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-([4-[4-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)phenoxy]phenyl]carbonyl)isoleucinamide	37°C, pH 4.4	Plasmodium falciparum
0.000087	-	propyl N-[(4-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]phenoxy]phenyl)carbonyl]-L-leucyl-L-lysinate	37°C, pH 4.4	Plasmodium falciparum
0.00012	-	N-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-4-oxobutanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium falciparum
0.00016	-	N-[4-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)amino]-4-oxobutanoyl]-L-leucyl-N-[4-[(6-methoxyquinolin-8-yl)amino]pentyl]-L-lysinamide	37°C, pH 4.4	Plasmodium ovale
0.00025	-	N-[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-N2-[[4-(4-[[(1R)-1-([4-[(6-methoxyquinolin-8-yl)amino]pentyl]carbamoyl)-3-methylbutyl]carbamoyl]phenoxy)phenyl]carbonyl]isoleucinamide	37°C, pH 4.4	Plasmodium falciparum
0.00026	-	N-([6-[(1-[[(1S,2S)-4-(butylamino)-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]carbamoyl]-2-methylbutyl)carbamoyl]naphthalen-2-yl]carbonyl)-L-leucine	37°C, pH 4.4	Plasmodium falciparum
0.00099	-	(3S,4S)-N-butyl-3-hydroxy-6-methyl-4-([N-[(naphthalen-2-yloxy)acetyl]isoleucyl]amino)heptanamide	37°C, pH 4.4	Plasmodium falciparum
0.0013	-	(3S,4S)-N-butyl-3-hydroxy-6-methyl-4-([N-[(naphthalen-2-yloxy)acetyl]isoleucyl]amino)heptanamide	37°C, pH 4.4	Plasmodium ovale