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Literature summary for 3.4.23.B14 extracted from

  • Clemente, J.C.; Govindasamy, L.; Madabushi, A.; Fisher, S.Z.; Moose, R.E.; Yowell, C.A.; Hidaka, K.; Kimura, T.; Hayashi, Y.; Kiso, Y.; Agbandje-McKenna, M.; Dame, J.B.; Dunn, B.M.; McKenna, R.
    Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor (2006), Acta Crystallogr. Sect. D, D62, 246-252.
    View publication on PubMed
Search for more literature for 3.4.23.B14

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor-diffusion method, crystal structure of plasmepsin 4 bound to the allophenylnorstatine-based compound KNI-764 at 3.3 A resolution. The PmPM4–inhibitor complex crystallized in the ortho-rhombic space group P2(1)2(1)2, with unit-cell parameters a = 95.9 A, b = 112.6 A, c = 90.4 A, with two molecules in the asymmetric unit Plasmodium malariae

Inhibitors

Inhibitors Comment Organism Structure
(4R)-3-[(2S,3S)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide
-
 Plasmodium malariae
(4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
-
 Plasmodium malariae
N-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(cyclohexa-1,3-dien-1-yloxy)acetyl]-L-valinamide
-
 Plasmodium malariae
N-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(isoquinolin-5-yloxy)acetyl]-L-valinamide
-
 Plasmodium malariae
N1-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(isoquinolin-5-yloxy)acetyl]-L-aspartamide
-
 Plasmodium malariae

Localization

Localization Comment Organism GeneOntology No. Textmining
vacuole food vacuole Plasmodium malariae 5773
-

Organism

Organism UniProt Comment Textmining
Plasmodium malariae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Plasmodium malariae

Synonyms

Synonyms Comment Organism
plasmepsin 4
-
 Plasmodium malariae
PmPM4
-
 Plasmodium malariae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000025
-
 N-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(isoquinolin-5-yloxy)acetyl]-L-valinamide
-
 Plasmodium malariae
0.00011
-
 (4R)-3-[(2S,3S)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide
-
 Plasmodium malariae
0.00016
-
 N-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(cyclohexa-1,3-dien-1-yloxy)acetyl]-L-valinamide
-
 Plasmodium malariae
0.003
-
 N-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(isoquinolin-5-yloxy)acetyl]-L-valinamide
-
 Plasmodium malariae
0.003
-
 (4R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)carbonyl]amino]-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
-
 Plasmodium malariae
0.0071
-
 N1-[(1S,2S)-1-benzyl-3-[(4R)-4-(tert-butylcarbamoyl)-5,5-dimethyl-1,3-thiazolidin-3-yl]-2-hydroxy-3-oxopropyl]-N2-[(isoquinolin-5-yloxy)acetyl]-L-aspartamide
-
 Plasmodium malariae