3.4.21.B39: stratum corneum tryptic enzyme
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For detailed information about stratum corneum tryptic enzyme, go to the full flat file.
Word Map on EC 3.4.21.B39
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3.4.21.B39
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klk5
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keratinocytes
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desquamation
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cathelicidin
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netherton
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spink5
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rosacea
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kazal-type
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lekti
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filaggrin
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lympho-epithelial
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corneodesmosomes
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transepidermal
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lymphopoietin
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corneodesmosin
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kazal
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desmocollin
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corneocyte
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medicine
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diagnostics
- 3.4.21.B39
- klk5
- keratinocytes
-
desquamation
- cathelicidin
- netherton
-
spink5
- rosacea
-
kazal-type
- lekti
- filaggrin
-
lympho-epithelial
-
corneodesmosomes
-
transepidermal
- lymphopoietin
- corneodesmosin
-
kazal
-
desmocollin
-
corneocyte
- medicine
- diagnostics
Reaction
proteolytic cleavage of polypeptides =
Synonyms
GK-5, hK5, HSC tryptic enzyme, human kallikrein 5, human stratum corneum trypsin-like enzyme, human tissue kallikrein 5, K5, kallikrein 5, kallikrein protein 5, kallikrein-5, kallikrein-like protein 2, kallikrein-related peptidase 5, KLK-L2, KLK5, More, S01.017, SCTE, strateum-corneum trypsin-like serine protease, stratum corneum tryptic enzyme, tissue kallikrein, tissue kallikrein 5
ECTree
3.4.21.B39 stratum corneum tryptic enzymeAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.21.B39 - stratum corneum tryptic enzyme
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
gene overexpression in a subset of more aggressive ovarian tumors
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decreased immunohistochemical expression compared to normal cells
KLK5 peaks slightly at mid-cycle and shows a major peak at day 25 of menstrual cycle
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expression levels of KLK5 and KLK7 in benign breast tissues and metastases, and the relationship between KLK5 and KLK7 expression and and clinicopathological factors. mRNA levels of KLK5 and KLK7 in normal breast tissues, benign breast tissues, primary tumors, and lymph node metastases, overview. mRNA levels of KLK5 and KLK7 are both downregulated in breast cancers relative to normal and benign tissues, and downregulated in metastases compared to primary cancers
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expression levels of KLK5 and KLK7 in benign breast tissues and metastases, and the relationship between KLK5 and KLK7 expression and and clinicopathological factors. mRNA levels of KLK5 and KLK7 in normal breast tissues, benign breast tissues, primary tumors, and lymph node metastases, overview. mRNA levels of KLK5 and KLK7 are both downregulated in breast cancers relative to normal and benign tissues, and downregulated in metastases compared to primary cancers
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kallikreins 5, 7, 8, and 10 are abundantly expressed in human oral squamous cell carcinoma and may be implicated in malignant progression
specimens from patients with benign prostatic hyperplasia (BPH) show higher levels of KLK5 mRNA expression than those from patients with prostate cancer
kallikrein-related peptidase 5 is a major serine protease found in the skin, which is secreted from lamellar granules following its expression in the stratum granulosum and activated in the extracellular space of the stratum corneum
