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Literature summary for 3.4.21.B39 extracted from

  • Sakabe, J.; Yamamoto, M.; Hirakawa, S.; Motoyama, A.; Ohta, I.; Tatsuno, K.; Ito, T.; Kabashima, K.; Hibino, T.; Tokura, Y.
    Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes (2013), J. Biol. Chem., 288, 17179-17189.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B39

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockout in NHEK cells using KLK5 shRNA expressing vectors Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted from lamellar granules in the skin and activated in the extracellular space of the stratum corneum Homo sapiens
-
-
lamellar body
-
 Homo sapiens 42599
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proform filaggrin + H2O Homo sapiens the enzyme and profilaggrin co-localize in the stratum granulosum in human epidermis. The enzyme interacts with its substrates in granular cells mature filaggrin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y337 gene KLK5
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Homo sapiens
-
granular cell
-
 Homo sapiens
-
skin kallikrein-related peptidase 5 is a major serine protease found in the skin, which is secreted from lamellar granules following its expression in the stratum granulosum and activated in the extracellular space of the stratum corneum Homo sapiens
-
stratum granulosum enzyme expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proform filaggrin + H2O the enzyme and profilaggrin co-localize in the stratum granulosum in human epidermis. The enzyme interacts with its substrates in granular cells Homo sapiens mature filaggrin + ?
-
 ?
proform filaggrin + H2O the filaggrin linker domain is the site for processing, recombinant human 53-kDa filaggrin protein Homo sapiens mature filaggrin + ? 41-kDa filaggrin fragment ?

Synonyms

Synonyms Comment Organism
kallikrein-related peptidase 5
-
 Homo sapiens
KLK5
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction KLK5 knockdown in normal cultured human epidermal keratinocytes results in higher levels of profilaggrin Homo sapiens