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Literature summary for 3.4.21.B39 extracted from

  • Michael, I.P.; Pampalakis, G.; Mikolajczyk, S.D.; Malm, J.; Sotiropoulou, G.; Diamandis, E.P.
    Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression (2006), J. Biol. Chem., 281, 12743-12750.
    View publication on PubMed
Search for more literature for 3.4.21.B39

Activating Compound

Activating Compound Comment Organism Structure
citrate 17% activation at 120 nM, 32% activation at 1200 nM Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Zn2+ 75% inhibition at 12 nM, 93.5% inhibition at 60 nM, 97.5% inhibition at 120 nM, complete inhibition at 1200 nM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Thr-Pro-Lys-Ile-Phe-Asn + H2O moderate cleavage efficiency Homo sapiens Ala-Thr-Pro-Lys + Ile-Phe-Asn
-
 ?
Asp-Gly-Asp-Lys-Ile-Ile-Glu + H2O low cleavage efficiency Homo sapiens Asp-Gly-Asp-Lys + Ile-Ile-Glu
-
 ?
Asp-Thr-Arg-Ala-Ile-Gly + H2O moderate cleavage efficiency Homo sapiens Asp-Thr-Arg + Ala-Ile-Gly
-
 ?
Gln-Glu-Asp-Lys-Val-Leu-Gly + H2O low cleavage efficiency Homo sapiens Gln-Glu-Asp-Lys + Val-Leu-Gly
-
 ?
Gln-Gly-Asp-Lys-Ile-Ile-Asp + H2O low cleavage efficiency Homo sapiens Gln-Gly-Asp-Lys + Ile-Ile-Asp
-
 ?
Glu-Thr-Arg-Ile-Ile-Lys + H2O moderate cleavage efficiency Homo sapiens Glu-Thr-Arg + Ile-Ile-Lys
-
 ?
hK3 + H2O hK5 can inactivate hK3 by subsequent cleavage after activation Homo sapiens ?
-
 ?
Ile-Gln-Ser-Arg-Ile-Val-Gly + H2O high cleavage efficiency Homo sapiens Ile-Gln-Ser-Arg + Ile-Val-Gly
-
 ?
Ile-Leu-Ser-Arg-Ile-Val-Gly + H2O high cleavage efficiency Homo sapiens Ile-Leu-Ser-Arg + Ile-Val-Gly
-
 ?
insulin-like growth factor-binding protein 1 + H2O cleavage after Lys137 Homo sapiens insulin-like growth factor-binding protein 1a + insulin-like growth factor-binding protein 1b
-
 ?
insulin-like growth factor-binding protein 1 + H2O cleavage after Arg170 Homo sapiens insulin-like growth factor-binding protein 4a + insulin-like growth factor-binding protein 4b
-
 ?
insulin-like growth factor-binding protein 2 + H2O cleavage after Arg164 Homo sapiens insulin-like growth factor-binding protein 2a + insulin-like growth factor-binding protein 2b
-
 ?
insulin-like growth factor-binding protein 3 + H2O cleavage after Arg158 and Arg206 Homo sapiens insulin-like growth factor-binding protein 3a + insulin-like growth factor-binding protein 3b + insulin-like growth factor-binding protein 3c
-
 ?
insulin-like growth factor-binding protein 5 + H2O cleavage after Arg123 and Arg212 Homo sapiens insulin-like growth factor-binding protein 5a + insulin-like growth factor-binding protein 5b + insulin-like growth factor-binding protein 5c
-
 ?
pro-hK2 + H2O hK5 can activate hK2 through cleavage after Lys137 Homo sapiens hK2 + ?
-
 ?
pro-hK3 + H2O hK5 can activate hK3 through cleavage after Arg85 and Lys182 Homo sapiens hK3 + ?
-
 ?
Ser-Ser-Ser-Arg-Ile-Ile-Asn + H2O moderate cleavage efficiency Homo sapiens Ser-Ser-Ser-Arg + Ile-Ile-Asn
-
 ?

Synonyms

Synonyms Comment Organism
hK5
-
 Homo sapiens
human tissue kallikrein 5
-
 Homo sapiens