3.4.21.B39: stratum corneum tryptic enzyme
This is an abbreviated version!
For detailed information about stratum corneum tryptic enzyme, go to the full flat file.
Word Map on EC 3.4.21.B39
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3.4.21.B39
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klk5
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keratinocytes
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desquamation
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cathelicidin
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netherton
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spink5
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rosacea
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kazal-type
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lekti
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filaggrin
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lympho-epithelial
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corneodesmosomes
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transepidermal
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lymphopoietin
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corneodesmosin
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kazal
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desmocollin
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corneocyte
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medicine
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diagnostics
- 3.4.21.B39
- klk5
- keratinocytes
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desquamation
- cathelicidin
- netherton
-
spink5
- rosacea
-
kazal-type
- lekti
- filaggrin
-
lympho-epithelial
-
corneodesmosomes
-
transepidermal
- lymphopoietin
- corneodesmosin
-
kazal
-
desmocollin
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corneocyte
- medicine
- diagnostics
Reaction
proteolytic cleavage of polypeptides =
Synonyms
GK-5, hK5, HSC tryptic enzyme, human kallikrein 5, human stratum corneum trypsin-like enzyme, human tissue kallikrein 5, K5, kallikrein 5, kallikrein protein 5, kallikrein-5, kallikrein-like protein 2, kallikrein-related peptidase 5, KLK-L2, KLK5, More, S01.017, SCTE, strateum-corneum trypsin-like serine protease, stratum corneum tryptic enzyme, tissue kallikrein, tissue kallikrein 5
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 3.4.21.B39 - stratum corneum tryptic enzyme
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REACTION DIAGRAM
defensin-1alpha + H2O
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KLK5 is capable of processing defensin-1alpha and may be important in vaginal host defense
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proform filaggrin + H2O
mature filaggrin + ?
the enzyme and profilaggrin co-localize in the stratum granulosum in human epidermis. The enzyme interacts with its substrates in granular cells
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polypeptide + H2O
peptides
enzyme is regulated by binding to protease inhibitors
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additional information
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the enzyme is differentially expressed at the mRNA and protein level in diverse malignancies including cancer
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additional information
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the enzyme is differentially expressed at the mRNA and protein level in diverse malignancies including cancer
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additional information
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KLK5 plays a central role in skin desquamation as an initiating activating enzyme in proteolytic cascades formed by kallikreins
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additional information
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unregulated KLK5 directly activates proteinase-activated receptor 2 and induces nuclear factor kappaB-mediated overexpression of TSLP, intercellular adhesion molecule 1, tumor necrosis factor alpha, and IL8
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additional information
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unregulated KLK5 directly activates proteinase-activated receptor 2 and induces nuclear factor kappaB-mediated overexpression of TSLP, intercellular adhesion molecule 1, tumor necrosis factor alpha, and IL8
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