3.4.21.B39: stratum corneum tryptic enzyme

This is an abbreviated version!
For detailed information about stratum corneum tryptic enzyme, go to the full flat file.

Word Map on EC 3.4.21.B39

3.4.21.B39

klk5

keratinocytes

desquamation

cathelicidin

netherton

spink5

rosacea

kazal-type

lekti

filaggrin

lympho-epithelial

corneodesmosomes

transepidermal

lymphopoietin

corneodesmosin

kazal

desmocollin

corneocyte

medicine

diagnostics

Reaction

proteolytic cleavage of polypeptides =

Synonyms

GK-5, hK5, HSC tryptic enzyme, human kallikrein 5, human stratum corneum trypsin-like enzyme, human tissue kallikrein 5, K5, kallikrein 5, kallikrein protein 5, kallikrein-5, kallikrein-like protein 2, kallikrein-related peptidase 5, KLK-L2, KLK5, More, S01.017, SCTE, strateum-corneum trypsin-like serine protease, stratum corneum tryptic enzyme, tissue kallikrein, tissue kallikrein 5

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B39 stratum corneum tryptic enzyme

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Results	in table
7	Activating Compound
3	AA Sequence
6	Application
2	CAS Registry Number
13	Cloned(Commentary)
3	Crystallization (Commentary)
237	Disease/ Diagnostics
6	Expression
11	General Information
8	IC50 Value
51	Inhibitors
1	kcat/KM [mM/s]
17	Ki Value [mM]
20	KM Value [mM]
3	Localization
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
43	Organism
6	pH Optimum
1	pH Range
6	Posttranslational Modification
1	Protein Variants
8	Purification (Commentary)
6	Reaction
8	Reaction Type
41	Reference
105	Source Tissue
1	Storage Stability
98	Substrates and Products (Substrate)
2	Subunits
72	Synonyms
3	Temperature Optimum [°C]
18	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.21.B39 - stratum corneum tryptic enzyme

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defensin-1alpha + H2O

Homo sapiens

Q9Y337

KLK5 is capable of processing defensin-1alpha and may be important in vaginal host defense

desmocollin-2 + H2O

desmocollin-3 + H2O

desmoglein 1 + H2O

desmoglein protein 1 + H2O

mucin 4 + H2O

mucin 5B + H2O

polypeptide + H2O

peptides

3 entries

proform filaggrin + H2O

mature filaggrin + ?

Homo sapiens

Q9Y337

the enzyme and profilaggrin co-localize in the stratum granulosum in human epidermis. The enzyme interacts with its substrates in granular cells

732104

additional information

7 entries