Literature summary for 3.4.21.B39 extracted from

Deraison, C.; Bonnart, C.; Lopez, F.; Besson, C.; Robinson, R.; Jayakumar, A.; Wagberg, F.; Brattsand, M.; Hachem, J.P.; Leonardsson, G.; Hovnanian, A.
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction (2007), Mol. Biol. Cell, 18, 3607-3619.

Search for more literature for 3.4.21.B39

Inhibitors

Inhibitors	Comment	Organism	Structure
lympho-epithelial Kazal type inhibitor fragment D5	-	Homo sapiens
lympho-epithelial Kazal type inhibitor fragment D6	-	Homo sapiens
lympho-epithelial Kazal type inhibitor fragment D8-D11	-	Homo sapiens
lympho-epithelial Kazal type inhibitor fragment D9-D15	-	Homo sapiens
additional information	not inhibited by lympho-epithelial Kazal type inhibitor fragment D1	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.6	-	L-Ile-Pro-Arg-p-nitroanilide	in 0.1 M Tris, 0.5 M NaCl, pH 8	Homo sapiens
0.6	-	L-Ile-Pro-Arg-p-nitroanilide	L-Ile-Pro-Arg-4-nitroanilide	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y337	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epidermis	-	Homo sapiens	-
keratinocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-Ile-Pro-Arg-p-nitroanilide + H2O	-	Homo sapiens	D-Ile-Pro-Arg + p-nitroaniline	-	?
L-Ile-Pro-Arg-4-nitroanilide + H2O	-	Homo sapiens	L-Ile-Pro-Arg + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
kallikrein 5	-	Homo sapiens
KLK5	-	Homo sapiens
SCTE	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000037	-	lympho-epithelial Kazal type inhibitor fragment D8-11	-	Homo sapiens
0.0000328	-	lympho-epithelial Kazal type inhibitor fragment D5	-	Homo sapiens
0.0000833	-	lympho-epithelial Kazal type inhibitor fragment D6	-	Homo sapiens
0.0001187	-	lympho-epithelial Kazal type inhibitor fragment D9-15	-	Homo sapiens

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Release 2023.1 (January 2023)