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3.4.21.B39: stratum corneum tryptic enzyme

This is an abbreviated version!
For detailed information about stratum corneum tryptic enzyme, go to the full flat file.

Word Map on EC 3.4.21.B39

Reaction

proteolytic cleavage of polypeptides =

Synonyms

GK-5, hK5, HSC tryptic enzyme, human kallikrein 5, human stratum corneum trypsin-like enzyme, human tissue kallikrein 5, K5, kallikrein 5, kallikrein protein 5, kallikrein-5, kallikrein-like protein 2, kallikrein-related peptidase 5, KLK-L2, KLK5, More, S01.017, SCTE, strateum-corneum trypsin-like serine protease, stratum corneum tryptic enzyme, tissue kallikrein, tissue kallikrein 5

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B39 stratum corneum tryptic enzyme

Reference

topprint

Reference on EC 3.4.21.B39 - stratum corneum tryptic enzyme

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (P15945), Homo sapiens (Q9Y337)
Manually annotated by BRENDA team
Yousef, G.M.; Diamandis, E.P.
The new human tissue kallikrein gene family: structure, function, and association to disease
Endocr. Rev.
22
184-204
2001
Homo sapiens (Q9Y337)
Manually annotated by BRENDA team
Brattsand, M.; Egelrud, T.
Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation
J. Biol. Chem.
274
30033-30040
1999
Homo sapiens (Q9Y337), Homo sapiens
Manually annotated by BRENDA team
Ekholm, I.E.; Brattsand, M.; Egelrud, T.
Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?
J. Invest. Dermatol.
114
56-63
2000
Homo sapiens (Q9Y337), Homo sapiens
Manually annotated by BRENDA team
Yousef, G.M.; Kapadia, C.; Polymeris, M.E.; Borgono, C.; Hutchinson, S.; Wasney, G.A.; Soosaipillai, A.; Diamandis, E.P.
The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease inhibitors in ovarian cancer fluids
Biochim. Biophys. Acta
1628
88-96
2003
Homo sapiens (Q9Y337), Homo sapiens
Manually annotated by BRENDA team
Prezas, P.; Arlt, M.J.; Viktorov, P.; Soosaipillai, A.; Holzscheiter, L.; Schmitt, M.; Talieri, M.; Diamandis, E.P.; Krueger, A.; Magdolen, V.
Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells
Biol. Chem.
387
807-811
2006
Homo sapiens
Manually annotated by BRENDA team
Caubet, C.; Jonca, N.; Brattsand, M.; Guerrin, M.; Bernard, D.; Schmidt, R.; Egelrud, T.; Simon, M.; Serre, G.
Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
J. Invest. Dermatol.
122
1235-1244
2004
Homo sapiens
Manually annotated by BRENDA team
Michael, I.P.; Sotiropoulou, G.; Pampalakis, G.; Magklara, A.; Ghosh, M.; Wasney, G.; Diamandis, E.P.
Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression
J. Biol. Chem.
280
14628-14635
2005
Homo sapiens
Manually annotated by BRENDA team
Michael, I.P.; Pampalakis, G.; Mikolajczyk, S.D.; Malm, J.; Sotiropoulou, G.; Diamandis, E.P.
Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression
J. Biol. Chem.
281
12743-12750
2006
Homo sapiens
Manually annotated by BRENDA team
Komatsu, N.; Tsai, B.; Sidiropoulos, M.; Saijoh, K.; Levesque, M.A.; Takehara, K.; Diamandis, E.P.
Quantification of eight tissue kallikreins in the Stratum corneum and sweat
J. Invest. Dermatol.
126
925-929
2006
Homo sapiens
Manually annotated by BRENDA team
Kurlender, L.; Yousef, G.M.; Memari, N.; Robb, J.D.; Michael, I.P.; Borgono, C.; Katsaros, D.; Stephan, C.; Jung, K.; Diamandis, E.P.
Differential expression of a human kallikrein 5 (KLK5) splice variant in ovarian and prostate cancer
Tumour Biol.
25
149-156
2004
Homo sapiens
Manually annotated by BRENDA team
Yousef, G.M.; White, N.M.; Kurlender, L.; Michael, I.; Memari, N.; Robb, J.D.; Katsaros, D.; Stephan, C.; Jung, K.; Diamandis, E.P.
The kallikrein gene 5 splice variant 2 is a new biomarker for breast and ovarian cancer
Tumour Biol.
25
221-227
2005
Homo sapiens
Manually annotated by BRENDA team
Petraki, C.D.; Gregorakis, A.K.; Vaslamatzis, M.M.; Papanastasiou, P.A.; Yousef, G.M.; Levesque, M.A.; Diamandis, E.P.
Prognostic Implications of the Immunohistochemical Expression of Human Kallikreins 5, 6, 10 and 11 in Renal Cell Carcinoma
Tumour Biol.
27
1-7
2006
Homo sapiens
Manually annotated by BRENDA team
Shinoda, Y.; Kozaki, K.; Imoto, I.; Obara, W.; Tsuda, H.; Mizutani, Y.; Shuin, T.; Fujioka, T.; Miki, T.; Inazawa, J.
Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells
Cancer Sci.
98
1078-1086
2007
Homo sapiens
Manually annotated by BRENDA team
Voegeli, R.; Rawlings, A.V.; Doppler, S.; Heiland, J.; Schreier, T.
Profiling of serine protease activities in human stratum corneum and detection of a stratum corneum tryptase-like enzyme
Int. J. Cosmet. Sci.
29
191-200
2007
Homo sapiens
Manually annotated by BRENDA team
Debela, M.; Magdolen, V.; Schechter, N.; Valachova, M.; Lottspeich, F.; Craik, C.S.; Choe, Y.; Bode, W.; Goettig, P.
Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
J. Biol. Chem.
281
25678-25688
2006
Homo sapiens (Q9Y337)
Manually annotated by BRENDA team
Debela, M.; Goettig, P.; Magdolen, V.; Huber, R.; Schechter, N.M.; Bode, W.
Structural basis of the zinc inhibition of human tissue kallikrein 5
J. Mol. Biol.
373
1017-1031
2007
Homo sapiens (Q9Y337), Homo sapiens
Manually annotated by BRENDA team
Deraison, C.; Bonnart, C.; Lopez, F.; Besson, C.; Robinson, R.; Jayakumar, A.; Wagberg, F.; Brattsand, M.; Hachem, J.P.; Leonardsson, G.; Hovnanian, A.
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
Mol. Biol. Cell
18
3607-3619
2007
Homo sapiens (Q9Y337)
Manually annotated by BRENDA team
Rajapakse, S.; Ogiwara, K.; Yamano, N.; Kimura, A.; Hirata, K.; Takahashi, S.; Takahashi, T.
Characterization of mouse tissue kallikrein 5
Zool. Sci.
23
963-968
2006
Mus musculus
Manually annotated by BRENDA team
Shaw, J.L.; Petraki, C.; Watson, C.; Bocking, A.; Diamandis, E.P.
Role of tissue kallikrein-related peptidases in cervical mucus remodeling and host defense
Biol. Chem.
389
1513-1522
2008
Homo sapiens (Q9Y337)
Manually annotated by BRENDA team
Debela, M.; Beaufort, N.; Magdolen, V.; Schechter, N.M.; Craik, C.S.; Schmitt, M.; Bode, W.; Goettig, P.
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7
Biol. Chem.
389
623-632
2008
Homo sapiens
Manually annotated by BRENDA team
Korbakis, D.; Gregorakis, A.K.; Scorilas, A.
Quantitative analysis of human kallikrein 5 (KLK5) expression in prostate needle biopsies: an independent cancer biomarker
Clin. Chem.
55
904-913
2009
Homo sapiens (Q9Y337), Homo sapiens
Manually annotated by BRENDA team
Pettus, J.R.; Johnson, J.J.; Shi, Z.; Davis, J.W.; Koblinski, J.; Ghosh, S.; Liu, Y.; Ravosa, M.J.; Frazier, S.; Stack, M.S.
Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity
Histol. Histopathol.
24
197-207
2009
Homo sapiens
Manually annotated by BRENDA team
Brattsand, M.; Stefansson, K.; Hubiche, T.; Nilsson, S.K.; Egelrud, T.
SPINK9: A selective, skin-specific Kazal-type serine protease inhibitor
J. Invest. Dermatol.
129
1656-1665
2009
Homo sapiens
Manually annotated by BRENDA team
Meyer-Hoffert, U.; Wu, Z.; Schroeder, J.M.
Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor
PLoS ONE
4
e4372
2009
Homo sapiens
Manually annotated by BRENDA team
Mavridis, K.; Talieri, M.; Scorilas, A.
KLK5 gene expression is severely upregulated in androgen-independent prostate cancer cells after treatment with the chemotherapeutic agents docetaxel and mitoxantrone
Biol. Chem.
391
467-474
2010
Homo sapiens (Q9Y337)
Manually annotated by BRENDA team
Li, X.; Liu, J.; Wang, Y.; Zhang, L.; Ning, L.; Feng, Y.
Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies
Cancer Sci.
100
601-607
2009
Homo sapiens
Manually annotated by BRENDA team
Briot, A.; Deraison, C.; Lacroix, M.; Bonnart, C.; Robin, A.; Besson, C.; Dubus, P.; Hovnanian, A.
Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome
J. Exp. Med.
206
1135-1147
2009
Mus musculus (Q9D140), Mus musculus
Manually annotated by BRENDA team
Teixeira, T.S.; Freitas, R.F.; Abrahao, O.; Devienne, K.F.; de Souza, L.R.; Blaber, S.I.; Blaber, M.; Kondo, M.Y.; Juliano, M.A.; Juliano, L.; Puzer, L.
Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7
Bioorg. Med. Chem. Lett.
21
6112-6115
2011
Homo sapiens
Manually annotated by BRENDA team
Britland, S.; Hoyle, M.
Transcriptional gene silencing of kallikrein 5 and kallikrein 7 using siRNA prevents epithelial cell detachment induced by alkaline shock in an in vitro model of eczema
Biotechnol. Prog.
28
485-489
2011
Homo sapiens
Manually annotated by BRENDA team
Jiang, R.; Shi, Z.; Johnson, J.J.; Liu, Y.; Stack, M.S.
Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma
J. Biol. Chem.
286
9127-9135
2011
Homo sapiens
Manually annotated by BRENDA team
De Souza, L.; M. Melo, P.; Paschoalin, T.; Carmona, A.; Kondo, M.; Hirata, I.; Blaber, M.; Tersariol, I.; Takatsuka, J.; Juliano, M.; Juliano, L.; Gomes, R.; Puzer, L.
Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
Biochem. Biophys. Res. Commun.
433
333-337
2013
Homo sapiens (Q9Y337)
Manually annotated by BRENDA team
Sakabe, J.; Yamamoto, M.; Hirakawa, S.; Motoyama, A.; Ohta, I.; Tatsuno, K.; Ito, T.; Kabashima, K.; Hibino, T.; Tokura, Y.
Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes
J. Biol. Chem.
288
17179-17189
2013
Homo sapiens (Q9Y337), Homo sapiens
Manually annotated by BRENDA team
Santos, J.A.; Kondo, M.Y.; Freitas, R.F.; dos Santos, M.H.; Ramalho, T.C.; Assis, D.M.; Juliano, L.; Juliano, M.A.; Puzer, L.
The natural flavone fukugetin as a mixed-type inhibitor for human tissue kallikreins
Bioorg. Med. Chem. Lett.
26
1485-1489
2016
Homo sapiens
Manually annotated by BRENDA team
White, G.V.; Edgar, E.V.; Holmes, D.S.; Lewell, X.Q.; Liddle, J.; Polyakova, O.; Smith, K.J.; Thorpe, J.H.; Walker, A.L.; Wang, Y.; Young, R.J.; Hovnanian, A.
Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome
Bioorg. Med. Chem. Lett.
29
821-825
2019
Homo sapiens (Q9Y337)
Manually annotated by BRENDA team
Hoelz, L.V.B.; Zorzanelli, B.C.; Azevedo, P.H.R.A.; Passos, S.G.; de Souza, L.R.; Zani, M.; Pinheiro, S.; Puzer, L.; Dias, L.R.S.; Muri, E.M.F.
Synthesis, biological evaluation and molecular modeling of pseudo-peptides based statine as inhibitors for human tissue kallikrein 5
Eur. J. Med. Chem.
112
39-47
2016
Homo sapiens (Q9Y337), Homo sapiens
Manually annotated by BRENDA team
Andoh, T.; Tsujii, K.; Kuraishi, Y.
Increase in pruritogenic kallikrein 5 in the skin of NC mice with chronic dermatitis
Exp. Dermatol.
24
978-980
2015
Mus musculus (P15945)
Manually annotated by BRENDA team
Yang, F.; Li, J.Y.; Yin, Q.N.; Yang, K.; Dong, S.N.; Bai, L.J.; Liu, P.; Tong, X.W.
Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer tissue expression analysis and relationship with disease course
Genet. Mol. Res.
14
9655-9666
2015
Homo sapiens (Q9Y337), Homo sapiens
Manually annotated by BRENDA team
Cartner, T.; Brand, N.; Tian, K.; Saud, A.; Carr, T.; Stapleton, P.; Lane, M.E.; Rawlings, A.V.
Effect of different alcohols on stratum corneum kallikrein 5 and phospholipase A2 together with epidermal keratinocytes and skin irritation
Int. J. Cosmet. Sci.
39
188-196
2017
Homo sapiens (Q9Y337)
Manually annotated by BRENDA team
Jang, H.; Matsuda, A.; Jung, K.; Karasawa, K.; Matsuda, K.; Oida, K.; Ishizaka, S.; Ahn, G.; Amagai, Y.; Moon, C.; Kim, S.H.; Arkwright, P.D.; Takamori, K.; Matsuda, H.; Tanaka, A.
Skin pH is the master switch of kallikrein 5-mediated skin barrier destruction in a murine atopic dermatitis model
J. Invest. Dermatol.
136
127-135
2016
Mus musculus (P15945), Mus musculus
Manually annotated by BRENDA team