3.4.21.B39: stratum corneum tryptic enzyme

This is an abbreviated version!
For detailed information about stratum corneum tryptic enzyme, go to the full flat file.

Reaction

proteolytic cleavage of polypeptides =

Synonyms

GK-5, hK5, HSC tryptic enzyme, human kallikrein 5, human stratum corneum trypsin-like enzyme, human tissue kallikrein 5, K5, kallikrein 5, kallikrein protein 5, kallikrein-5, kallikrein-like protein 2, kallikrein-related peptidase 5, KLK-L2, KLK5, More, S01.017, SCTE, strateum-corneum trypsin-like serine protease, stratum corneum tryptic enzyme, tissue kallikrein, tissue kallikrein 5

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B39 stratum corneum tryptic enzyme

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Results	in table
7	Activating Compound
3	AA Sequence
6	Application
2	CAS Registry Number
13	Cloned(Commentary)
3	Crystallization (Commentary)
237	Disease/ Diagnostics
6	Expression
11	General Information
8	IC50 Value
51	Inhibitors
1	kcat/KM [mM/s]
17	Ki Value [mM]
20	KM Value [mM]
3	Localization
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
43	Organism
6	pH Optimum
1	pH Range
6	Posttranslational Modification
1	Protein Variants
8	Purification (Commentary)
6	Reaction
8	Reaction Type
41	Reference
105	Source Tissue
1	Storage Stability
98	Substrates and Products (Substrate)
2	Subunits
72	Synonyms
3	Temperature Optimum [°C]
18	Turnover Number [1/s]

Expression

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Expression on EC 3.4.21.B39 - stratum corneum tryptic enzyme

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

10 transcription factors as potential regulators are found on the control regions of both KLK5 and KLK7

Homo sapiens

-

707996

expression of kallikrein 5 is higher in oral squamous cell carcinoma cell compared to pre-malignant cells

Homo sapiens

-

717868

kallikrein 5 has increased activity levels in eczematous lesions

Homo sapiens

-

717412

KLK5 gene expression is severely upregulated in androgen-independent prostate cancer cells after treatment with the chemotherapeutic agents docetaxel and mitoxantrone

Homo sapiens

Q9Y337

707624

the enzyme is upregulated in some types of cancers, mainly prostate and ovarian cancers

Homo sapiens

Q9Y337

731251

the expression of KLK5 is increased in the epidermis of patients with atopic dermatitis and its activity increases in atopic dermatitis-like lesions

Mus musculus

P15945

753511