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Disease on EC 3.4.21.B39 - stratum corneum tryptic enzyme

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma.
Adenocarcinoma of Lung
PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
Breast Neoplasms
Down-regulation of kallikrein-related peptidase 5 (KLK5) expression in breast cancer patients: a biomarker for the differential diagnosis of breast lesions.
Evaluation of Kallikrein-related Peptidase 5 Expression and its Significance for Breast Cancer Patients: Association with Kallikrein-related Peptidase 7 Expression.
Kallikrein-related peptidase 5 induces miRNA-mediated anti-oncogenic pathways in breast cancer.
Molecular signatures associated with transformation and progression to breast cancer in the isogenic MCF10 model.
The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue expression, and hormonal regulation.
Carcinogenesis
Kallikrein 5 Inhibition by the Lympho-Epithelial Kazal-Type Related Inhibitor Hinders Matriptase-Dependent Carcinogenesis.
Carcinoma
Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response.
Kallikrein 5 Inhibition by the Lympho-Epithelial Kazal-Type Related Inhibitor Hinders Matriptase-Dependent Carcinogenesis.
Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma.
Kallikrein-related Peptidase 5 (KLK5) Expression and Distribution in Canine Cutaneous Squamous Cell Carcinoma.
The Co-Expression of Kallikrein 5 and Kallikrein 7 Associates with Poor Survival in Non-HPV Oral Squamous-Cell Carcinoma.
Carcinoma, Squamous Cell
Kallikrein-related Peptidase 5 (KLK5) Expression and Distribution in Canine Cutaneous Squamous Cell Carcinoma.
Chronic Urticaria
Decreased plasma kallikrein 5 concentrations in patients with chronic spontaneous urticaria.
Colitis
Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2?
Dandruff
Exacerbated dandruff in the absence of kallikrein-related peptidase 5 protease.
Dermatitis
Increase in pruritogenic kallikrein 5 in the skin of NC mice with chronic dermatitis.
Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model.
Eczema
Transcriptional gene silencing of kallikrein 5 and kallikrein 7 using siRNA prevents epithelial cell detachment induced by alkaline shock in an in vitro model of eczema.
Eosinophilic Esophagitis
Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis.
Influenza, Human
Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12.
Kallikrein-related peptidase 5 and seasonal influenza viruses, limitations of the experimental models for activating proteases.
Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs.
Mycosis Fungoides
Mechanisms of itching in mycosis fungoides: grade of itching correlates with eosinophil infiltration and kallikrein 5 expression.
Neoplasms
Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome.
Biochemical and enzymatic characterization of human kallikrein 5 (hK5), a novel serine protease potentially involved in cancer progression.
Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7.
Exploration of potential prognostic biomarkers in aflibercept plus FOLFIRI in Japanese patients with metastatic colorectal cancer.
Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors.
Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors.
Isomannide-based peptidomimetics as inhibitors for human tissue kallikreins 5 and 7.
Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer.
Kallikrein-related peptidase 5 induces miRNA-mediated anti-oncogenic pathways in breast cancer.
Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies.
PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
Quantitative analysis of human kallikrein 5 (KLK5) expression in prostate needle biopsies: an independent cancer biomarker.
Synthesis, biological evaluation and molecular modeling of pseudo-peptides based statine as inhibitors for human tissue kallikrein 5.
The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway.
Netherton Syndrome
A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome.
Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.
Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.
Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors.
Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallikreins.
Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome.
Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.
SPINK5 knockdown in organotypic human skin culture as a model system for Netherton syndrome: effect of genetic inhibition of serine proteases kallikrein 5 and kallikrein 7.
Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.
Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome.
Ovarian Neoplasms
Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome.
Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer.
Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response.
Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis.
Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer.
The human kallikrein protein 5 (hK5) is enzymatically active, glycosylated and forms complexes with two protease inhibitors in ovarian cancer fluids.
Prostatic Neoplasms
Differential expression of a human kallikrein 5 (KLK5) splice variant in ovarian and prostate cancer.
Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression.
Pruritus
Decreased plasma kallikrein 5 concentrations in patients with chronic spontaneous urticaria.
Mechanisms of itching in mycosis fungoides: grade of itching correlates with eosinophil infiltration and kallikrein 5 expression.
Psoriasis
Expression of bleomycin hydrolase in keratinization disorders.
Rosacea
A Novel Mechanism of Carvedilol Efficacy for Rosacea Treatment: Toll-Like Receptor 2 Inhibition in Macrophages.
Cathelicidin, kallikrein 5, and serine protease activity is inhibited during treatment of rosacea with azelaic acid 15% gel.
Citron Essential Oils Alleviate the Mediators Related to Rosacea Pathophysiology in Epidermal Keratinocytes.
Coptis chinensis Franch Directly Inhibits Proteolytic Activation of Kallikrein 5 and Cathelicidin Associated with Rosacea in Epidermal Keratinocytes.
Doxycycline Indirectly Inhibits Proteolytic Activation of Tryptic Kallikrein-Related Peptidases and Activation of Cathelicidin.
Endoplasmic reticulum stress: key promoter of rosacea pathogenesis.
Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects.
Kallikrein 5-Mediated Inflammation in Rosacea: Clinically Relevant Correlations with Acute and Chronic Manifestations in Rosacea and How Individual Treatments May Provide Therapeutic Benefit.
Multifunctional Serine Protease Inhibitor-Coated Water-Soluble Gold Nanoparticles as a Novel Targeted Approach for the Treatment of Inflammatory Skin Diseases.
TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes.
Skin Diseases
Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors.
Expression of bleomycin hydrolase in keratinization disorders.
Hyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving Effects.
Multifunctional Serine Protease Inhibitor-Coated Water-Soluble Gold Nanoparticles as a Novel Targeted Approach for the Treatment of Inflammatory Skin Diseases.
Screening of chemical libraries in pursuit of kallikrein-5 specific inhibitors for the treatment of inflammatory dermatoses.
Sleep Deprivation
Sleep loss and cytokines levels in an experimental model of psoriasis.
Squamous Cell Carcinoma of Head and Neck
Kallikrein 5 Inhibition by the Lympho-Epithelial Kazal-Type Related Inhibitor Hinders Matriptase-Dependent Carcinogenesis.
Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma.
Triple Negative Breast Neoplasms
Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course.
Ureteral Obstruction
MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis.
Urticaria
Decreased plasma kallikrein 5 concentrations in patients with chronic spontaneous urticaria.
Uterine Cervical Neoplasms
Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer.
Virus Diseases
Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs.
Vulvodynia
Decreased concentration of protease inhibitors: possible contributors to allodynia and hyperalgesia in women with vestibulodynia.